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Modafinil and unconstrained motor activity in schizophrenia: Double-blind crossover placebo-controlled trial

  • Tom F. D. Farrow (a1), Michael D. Hunter (a1), Rozana Haque (a1) and Sean A. Spence (a1)

Summary

Avolition affects quality of life in chronic schizophrenia. We investigated the effect of modafinil upon unconstrained motor activity in 18 male patients. In a randomised crossover design study wrist-worn actigraphic monitors were used to objectively record motor activity over a 20 h period. Patients' total activity was significantly greater when given the drug. These data suggest that modafinil increases quantifiable motor behaviour in schizophrenia and may have an impact on avolition.

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Copyright

Corresponding author

Dr Tom F. D. Farrow, SCANLab, Academic Clinical Psychiatry, University of Sheffield, he Longley Centre, Northern General Hospital, Norwood Grange Drive, Sheffield S5 7JT, UK. Email: t.f.farrow@sheffield.ac.uk

References

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Modafinil and unconstrained motor activity in schizophrenia: Double-blind crossover placebo-controlled trial

  • Tom F. D. Farrow (a1), Michael D. Hunter (a1), Rozana Haque (a1) and Sean A. Spence (a1)
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