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Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000–2014

  • Joseph F. Hayes (a1), Louise Marston (a2), Kate Walters (a2), Michael B. King (a3) and David P. J. Osborn (a3)...
Abstract
Background

Bipolar disorder and schizophrenia are associated with increased mortality relative to the general population. There is an international emphasis on decreasing this excess mortality.

Aims

To determine whether the mortality gap between individuals with bipolar disorder and schizophrenia and the general population has decreased.

Method

A nationally representative cohort study using primary care electronic health records from 2000 to 2014, comparing all patients diagnosed with bipolar disorder or schizophrenia and the general population. The primary outcome was all-cause mortality.

Results

Individuals with bipolar disorder and schizophrenia had elevated mortality (adjusted hazard ratio (HR) = 1.79, 95% CI 1.67–1.88 and 2.08, 95% CI 1.98–2.19 respectively). Adjusted HRs for bipolar disorder increased by 0.14/year (95% CI 0.10–0.19) from 2006 to 2014. The adjusted HRs for schizophrenia increased gradually from 2004 to 2010 (0.11/year, 95% CI 0.04–0.17) and rapidly after 2010 (0.34/year, 95% CI 0.18–0.49).

Conclusions

The mortality gap between individuals with bipolar disorder and schizophrenia, and the general population is widening.

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Copyright
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence.
Corresponding author
Joseph F. Hayes, Division of Psychiatry, UCL, 6th Floor Maple House, 149 Tottenham Court Road, London W1T 7NF, UK. Email: joseph.hayes@ucl.ac.uk
Footnotes
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See editorial, pp. 130–131, this issue.

Declaration of interest

None.

Footnotes
References
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Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000–2014

  • Joseph F. Hayes (a1), Louise Marston (a2), Kate Walters (a2), Michael B. King (a3) and David P. J. Osborn (a3)...
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