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Neural substrates of cognitive flexibility in cocaine and gambling addictions

  • Antonio Verdejo-Garcia (a1), Luke Clark (a2), Juan Verdejo-Román (a3), Natalia Albein-Urios (a3), José M. Martinez-Gonzalez (a3), Blanca Gutierrez (a4) and Carles Soriano-Mas (a5)...
Abstract
Background

Individuals with cocaine and gambling addictions exhibit cognitive flexibility deficits that may underlie persistence of harmful behaviours.

Aims

We investigated the neural substrates of cognitive inflexibility in cocaine users v. pathological gamblers, aiming to disambiguate common mechanisms v. cocaine effects.

Method

Eighteen cocaine users, 18 pathological gamblers and 18 controls performed a probabilistic reversal learning task during functional magnetic resonance imaging, and were genotyped for the DRD2/ANKK Taq1A polymorphism.

Results

Cocaine users and pathological gamblers exhibited reduced ventrolateral prefrontal cortex (PFC) signal during reversal shifting. Cocaine users further showed increased dorsomedial PFC (dmPFC) activation relative to pathological gamblers during perseveration, and decreased dorsolateral PFC activation relative to pathological gamblers and controls during shifting. Preliminary genetic findings indicated that cocaine users carrying the DRD2/ANKK Taq1A1+ genotype may derive unique stimulatory effects on shifting-related ventrolateral PFC signal.

Conclusions

Reduced ventrolateral PFC activation during shifting may constitute a common neural marker across gambling and cocaine addictions. Additional cocaine-related effects relate to a wider pattern of task-related dysregulation, reflected in signal abnormalities in dorsolateral and dmPFC.

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Copyright
Corresponding author
Antonio Verdejo-Garcia, School of Psychology and Psychiatry, Monash University, 3800 Wellington Rd. Clayton Campus, Melbourne, Australia. Email address: Antonio.Verdejo@monash.edu
Footnotes
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Declaration of interest

L.C.: The Centre for Gambling Research at UBC is funded by support from the Province of British Columbia and the British Columbia Lottery Corporation. The other authors declare no conflicts of interest concerning this study.

Footnotes
References
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Neural substrates of cognitive flexibility in cocaine and gambling addictions

  • Antonio Verdejo-Garcia (a1), Luke Clark (a2), Juan Verdejo-Román (a3), Natalia Albein-Urios (a3), José M. Martinez-Gonzalez (a3), Blanca Gutierrez (a4) and Carles Soriano-Mas (a5)...
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