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Neurodevelopmental indices and the development of psychotic symptoms in subjects at high risk of schizophrenia

  • Stephen M. Lawrie (a1), Majella Byrne (a1), Patrick Miller (a1), Ann Hodges (a1), Robert A. Clafferty (a1), David G. Cunningham Owens (a1) and Eve C. Johnstone (a1)...
Abstract
Background

Neurological ‘soft signs’ and minor physical anomalies (MPAs) are reported to be more frequent in patients with schizophrenia than in controls.

Aims

To determine whether these disturbances are genetically mediated, and whether they are central to the genesis of symptoms or epiphenomena.

Method

We obtained ratings in 152 individuals who were antipsychotic drug-free and at high risk, some of whom had experienced psychotic symptoms, as well as 30 first-episode patients and 35 healthy subjects.

Results

MPAs and Neurological Evaluation Scale (NES) ‘sensory integration abnormalities’ were more frequent in high-risk subjects than in healthy controls, but there were no reliable differences between high-risk subjects with and without psychotic symptoms. MPAs were most frequent in high-risk subjects with least genetic liability and NES scores showed no genetic associations.

Conclusions

The lack of associations with psychotic symptoms and genetic liability to schizophrenia suggests that soft signs and physical anomalies are non-specific markers of developmental deviance that are not mediated by the gene(s) for schizophrenia.

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Copyright
Corresponding author
Dr Stephen M. Lawrie, Edinburgh University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK. Tel: 0131-537-6671; Fax: 0131-447-6680; e-mail: s.lawrie@ed.ac.uk
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Declaration of interest

None. Funding from the Medical Research Council of Great Britain.

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References
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Arango, C. Kirkpatrick, B. & Buchanan, R. W. (2000) Neurological signs and the heterogeneity of schizophrenia. American Journal of Psychiatry, 157, 560565.
Boyes, J. Whalley, H. C. Lawrie, S. M. et al (2001) MRI assessment of hypertelorism in those at high risk of schizophrenia. Schizophrenia Research, in press.
Buchanan, R. W. & Heinrichs, D. W. (1989) The Neurological Evaluation Scale (NES): a structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Research, 27, 335350.
Bryne, M. Hodges, A. Grant, E. et al (1999) Neuropsychological assessment of young people at high genetic risk for developing schizophrenia compared with controls: preliminary findings of the Edinburgh High Risk Study (EHRS). Psychological Medicine, 29, 11611173.
Chen, Y. L. R. Chen, Y. H. E. & Mak, F. L. (2000) Soft neurological signs in schizophrenic patients and their nonpsychotic siblings. Journal of Nervous and Mental Disease, 188, 8489.
Diewert, V. M. Lozanoff, S. & Choy, V. (1993) Computer reconstructions of human embryonic craniofacial morphology showing changes in relations between the face and brain during primary palate formation. Journal of Craniofacial Genetics and Developmental Biology, 13, 193201.
Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview schedule for affective disorders and schizophrenia. Archives of General Psychiatry, 35, 837844.
Green, M. F. Satz, P. Gaier, D. J. et al (1989) Minor physical anomalies in schizophrenia. Schizophrenia Bulletin, 15, 9199.
Green, M. F. Satz, P. & Christenson, C. (1994) Minor physical anomalies in schizophrenia patients, bipolar patients, and their siblings. Schizophrenia Bulletin, 20, 433440.
Griffiths, T. D. Sigmundsson, T. Takei, N. et al (1998) Minor physical anomalies in familial and sporadic schizophrenia: the Maudsley family study. Journal of Neurology Neurosurgery and Psychiatry, 64, 5660.
Heinrichs, D. W. & Buchanan, R. W. (1988) Significance and meaning of neurological signs in schizophrenia. American Journal of Psychiatry, 145, 1118.
Hodges, A. Byrne, M. Grant, E. et al (1999) People at risk of schizophrenia. Sample characteristics of the first 100 cases in the Edinburgh High-Risk Study. British Journal of Psychiatry, 174, 547553.
Ismail, B. Cantor-Graae, E. & McNeil, T. F. (1998a) Minor physical anomalies in schizophrenic patients and their siblings. American Journal of Psychiatry, 155, 16951702.
Ismail, B. Cantor-Graae, E. & McNeil, T. F. (1998b) Neurological abnormalities in schizophrenic patients and their siblings. American Journal of Psychiatry, 155, 8489.
Johnstone, E. C. Abukmeil, S. S. Byrne, M. et al (2000) Edinburgh High Risk Study – findings after four years: demographic, attainment and psychopathological issues. Schizophrenia Research, 46, 115.
King, D. J. Wilson, A. Cooper, S. J. et al (1991) The clinical correlates of neurological soft signs in chronic schizophrenia. British Journal of Psychiatry, 158, 770775.
Kolakowska, T. Williams, A. O. Jambor, K. et al (1985) Schizophrenia with good and poor outcome. III: Neurological ‘soft’ signs, cognitive impairment and their clinical significance. British Journal of Psychiatry, 146, 348357.
Lane, A. Kinsella, A. Murphy, P. et al (1997) The anthropometric assessment of dysmorphic features in schizophrenia as an index of its developmental origins. Psychological Medicine, 27, 11551164.
Lawrie, S. M. Whalley, H. C. Abukmeil, S. S. et al (2001) Brain structure, genetic liability and psychotic symptoms in subjects at high risk of developing schizophrenia. Biological Psychiatry, in press.
Lohr, J. B. & Flynn, K. (1993) Minor physical anomalies in schizophrenia and mood disorders. Schizophrenia Bulletin, 19, 551556.
Marcus, J. Hans, S. L. Lewow, E. et al (1985) Neurological findings in high-risk children: childhood assessment and 5-year follow-up. Schizophrenia Bulletin, 11, 85100.
McGrath, J. J. van Os, J. Hoyos, C. et al (1995) Minor physical anomalies in psychoses: associations with clinical and putative aetiological variables. Schizophrenia Research, 18, 920.
McGuffin, P. Farmer, A. & Harvey, I. (1991) A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Archives of General Psychiatry, 48, 764770.
McNeil, T. F. Cantor-Graae, E. & Ismail, B. (2000) Obstetric complications and congenital malformation in schizophrenia. Brain Research Reviews, 31, 166178.
O'Callaghan, E. Buckley, P. Madigan, C. et al (1995) The relationship of minor physical anomalies and other putative indices of developmental disturbance in schizophrenia to abnormalities of cerebral structure on magnetic resonance imaging. Biological Psychiatry, 38, 516524.
Rossi, A. De Cataldo, S. Di Michele, V. et al (1990) Neurological soft signs in schizophrenia. British Journal of Psychiatry, 157, 736739.
Waldrop, M. F. & Halverson, C. F. Jr (1971) Minor Physical Anomalies and Hyperactive Behavior in Young Children. New York: Brunner/Mazel.
Ward, K. E. Friedman, L. Wise, A. et al (1996) Meta-analysis of brain and cranial size in schizophrenia. Schizophrenia Research, 22, 197213.
Wing, J. K. Cooper, J. E. & Sartorius, N. (1974) The Description and Classification of Psychiatric Symptoms. An Instruction Manual for the PSEand Catego Systems. Cambridge: Cambridge University Press.
Woods, B. T. Kinney, D. K. & Yurgelun-Todd, D. (1986) Neurologic abnormalities in schizophrenic patients and their families. I. Comparison of schizophrenic, bipolar, and substance abuse patients and normal controls. Archives of General Psychiatry, 43, 657663.
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  • ISSN: 0007-1250
  • EISSN: 1472-1465
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Neurodevelopmental indices and the development of psychotic symptoms in subjects at high risk of schizophrenia

  • Stephen M. Lawrie (a1), Majella Byrne (a1), Patrick Miller (a1), Ann Hodges (a1), Robert A. Clafferty (a1), David G. Cunningham Owens (a1) and Eve C. Johnstone (a1)...
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