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Neurometabolic approach to treatment-resistant depression

  • Edward H. Reynolds (a1)
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References

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1Malhi, GS, Das, P, Mannie, Z, Irwin, L. Treatment-resistant depression: problematic illness or a problem in our approach? Br J Psychiatry 2019; 214: 13.
2Strawbridge, R, Carter, B, Marwood, L, Bandelow, B, Tsapekos, D, Nikolova, VL, et al. Augmentation therapies for treatment-resistant depression: systematic review and meta-analysis. Br J Psychiatry 2019; 214: 4251.
3Bottiglieri, T, Laundy, M, Crellin, R, Toone, BK, Carney, MW, Reynolds, EH. Homocysteine, folate, methylation and monoamine metabolism in depression. J Neurol Neurosurg Psychiat 2000; 69: 228–32.
4Godfrey, PSA, Toone, BK, Carney, MWP, Flynn, TG, Bottiglieri, T, Laundy, M, Reynolds, EH. Enhancement of recovery from psychiatric illness by methylfolate. Lancet 1990; 336: 392–5.
5Papakostas, GI, Shelton, RC, Zajecka, JM, Etemad, B, Rickels, K, Clain, A, et al. L-methylfolate as adjunctive therapy for SSRI-resistant major depression. Am J Psychiatry 2012; 169: 1267–74.
6Reynolds, EH, Crellin, R, Bottiglieri, T, Laundy, M, Toone, BK, Carney, MWP. Methylfolate as monotherapy in depression. A pilot randomised controlled trial. J Neurol Psychol 2015; 3: 59.
7Sarris, J, Murphy, J, Mischoulon, D, Papakostas, GI, Fava, M, Berk, M, et al. Adjunctive nutraceuticals for depression: a systematic review and meta-analyses. Am J Psychiatry 2016; 173: 575–87.
8Pan, LA, Martin, P, Zimmer, T, Segreti, AM, Kassiff, S, McKain, BW, et al. Neurometabolic disorders: potentially treatable abnormalities in patients with treatment-refractory depression and suicidal behaviour. Am J Psychiatry 2017; 174: 4250.
9Fabbri, C, Kasper, S, Kautzky, A, Bartova, L, Dold, M, Zohar, J, et al. Genome-wide association study of treatment-resistance in depression and meta-analysis of three independent samples. Br J Psychiatry 2019; 214: 3641.
10Reynolds, EH. The neurology of folic acid deficiency. In Handbook of Clinical Neurology, Vol. 120 (eds Biller, J and Ferro, JM): 927–43. Amsterdam: Elsevier, 2014.

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Neurometabolic approach to treatment-resistant depression

  • Edward H. Reynolds (a1)
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