Skip to main content

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
Cancel
×
×
Home
  • Home
Article
  • Cited by 2
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Tripathi, Adarsh Kar, Sujita Kumar and Shukla, Rashmi 2018. Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies. Clinical Psychopharmacology and Neuroscience, Vol. 16, Issue. 1, p. 7.

    Ramsay, Ian S. Nienow, Tasha M. and MacDonald, Angus W. 2017. Increases in Intrinsic Thalamocortical Connectivity and Overall Cognition Following Cognitive Remediation in Chronic Schizophrenia. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 2, Issue. 4, p. 355.

    ×
  • Access

Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: Triple-blind trial

  • Ian S. Ramsay (a1), Tasha M. Nienow (a2), Matthew P. Marggraf (a3) and Angus W. MacDonald (a4)
Abstract
Background

Patients with schizophrenia have shown cognitive improvements following cognitive remediation, but the neuroplastic changes that support these processes are not fully understood.

 Aims

To use a triple-blind, placebo-controlled trial to examine neural activation before and after cognitive remediation or a computer skills training (CST) placebo (trial registration: NCT00995553)).

 Method

Twenty-seven participants underwent functional magnetic resonance imaging before and after being randomised to either cognitive remediation intervention or CST. Participants completed two variants of the N-back task during scanning and were assessed on measures of cognition, functional capacity, community functioning and symptoms.

 Results

We observed a group × time interaction in the left prefrontal cortex, wherein the cognitive remediation group showed increased activation. These changes correlated with improved task accuracy within the cognitive remediation group, whereas there was no relationship between changes in activation in untrained cognitive measures. Significant changes were not observed in other hypothesised areas for the cognitive remediation group.

 Conclusions

We replicated the finding that cognitive remediation increases left lateral prefrontal activation during a working memory task in patients with schizophrenia, suggesting this may be an important neural target for these types of interventions.
      • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: Triple-blind trial
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: Triple-blind trial
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: Triple-blind trial
      Available formats
      ×
Copyright
COPYRIGHT: © Royal College of Psychiatrists, 2017 
Corresponding author
Angus W. MacDonald, Department of Psychology, University of Minnesota, N219 Elliot Hall 75 E. River Rd, Minneapolis, MN 55455, USA. Email: angus@umn.edu
Footnotes
Hide All

Declaration of interest

None.

Footnotes
References
Hide All
1 McGurk, SR, Twamley, EW, Sitzer, DI, McHugo, GJ, Mueser, KT. A meta-analysis of cognitive remediation in schizophrenia. Am J Psychiatry 2007; 164: 1791–802.
2 Wykes, T, Huddy, V, Cellard, C, McGurk, SR, Czobor, P. A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes. Am J Psychiatry 2011; 168: 472–85.
3 Ramsay, IS, MacDonald, AW. Brain correlates of cognitive remediation in schizophrenia: activation likelihood analysis shows preliminary evidence of neural target engagement. Schizophr Bull 2015; 41: 1276–84.
4 Carter, CS, Perlstein, W, Ganguli, R, Brar, J, Mintun, M, Cohen, JD. Functional hypofrontality and working memory dysfunction in schizophrenia. Am J Psychiatry 1998; 155: 1285–7.
5 Silver, H, Feldman, P, Bilker, W, Gur, RC. Working memory deficit as a core neuropsychological dysfunction in schizophrenia. Am J Psychiatry 2003; 160: 1809–16.
6 Granholm, E, McQuaid, JR, McClure, FS, Auslander, LA, Perivoliotis, D, Pedrelli, P, et al. A randomized, controlled trial of cognitive behavioral social skills training for middle-aged and older outpatients with chronic schizophrenia. Am J Psychiatry 2005; 162: 520–9.
7 Haut, KM, Lim, KO, MacDonald, A. Prefrontal cortical changes following cognitive training in patients with chronic schizophrenia: effects of practice, generalization, and specificity. Neuropsychopharmacology 2010; 35: 1850–9.
8 Kurtz, MM, Seltzer, JC, Fujimoto, M, Shagan, DS, Wexler, BE. Predictors of change in life skills in schizophrenia after cognitive remediation. Schizophr Res 2009; 107: 267–74.
9 Fiszdon, JM, Cardenas, AS, Bryson, GJ, Bell, MD. Predictors of remediation success on a trained memory task. J Nerv Ment Dis 2005; 193: 602–8.
10 Fiszdon, JM, McClough, JF, Silverstein, SM, Bell, MD, Jaramillo, JR, Smith, TE. Learning potential as a predictor of readiness for psychosocial rehabilitation in schizophrenia. Psychiatry Res 2006; 143: 159–66.
11 First, MB et, Spitzer, RL, Gibbon, M, Williams, JBW. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV) for DSMIV. New York State Psychiatric Institute, 1997.
12 Wechsler, D. Wechsler Test of Adult Reading: WTAR. Psychological Corporation, 2001.
13 Gevins, AS, Cutillo, BC. Neuroelectric evidence for distributed processing in human working memory. Electroenceph Clin Neurophysiol 1993; 87: 128–43.
14 Nuechterlein, KH. Vigilance in schizophrenia and related disorders. In Handbook of Schizophrenia Vol 5: Neuropsychology, Psychophysiology, and Information Processing (eds Steinhauer, SR, Gruzelier, JH and Zubin, J): 397–433. Elsevier, 1991.
15 Nuechterlein, KH, Green, MF, Kern, RS, Baade, LE, Barch, DM, Cohen, JD, et al. The MATRICS consensus cognitive battery, part 1: test selection, reliability, and validity. Am J Psychiatry 2008; 165: 203–13.
16 Patterson, TL, Goldman, S, McKibbin, CL, Hughs, T, Jeste, DV. UCSD Performance-Based Skills Assessment: development of a new measure of everyday functioning for severely mentally ill adults. Schizophr Bull 2001; 27: 235–45.
17 Patterson, TL, Moscona, S, McKibbin, CL, Davidson, K, Jeste, D V. Social skills performance assessment among older patients with schizophrenia. Schizophr Res 2001; 48: 351–60.
18 Birchwood, M, Smith, J, Cochrane, R, Wetton, S, Copestake, S. The Social Functioning Scale. The development and validation of a new scale of social adjustment for use in family intervention programmes with schizophrenic patients. Br J Psychiatry 1990; 157: 853–9.
19 Dingemans, PM. Brief Psychiatric Rating Scale (BPRS). J Clin Psychol 1990; 46: 168–74.
20 Subramaniam, K, Luks, TL, Fisher, M, Simpson, GV, Nagarajan, S. Supplemental information computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia. Neuron 2012; 73: 842–53.
21 Kurtz, MM, Seltzer, JC, Shagan, DS, Thime, WR, Wexler, BE. Computer-assisted cognitive remediation in schizophrenia: what is the active ingredient? Schizophr Res 2007; 89: 251–60.
22 Subramaniam, K, Luks, TL, Garrett, C, Chung, C, Fisher, M, Nagarajan, S, et al. Intensive cognitive training in schizophrenia enhances working memory and associated prefrontal cortical efficiency in a manner that drives long-term functional gains. Neuroimage 2014; 99: 281–92.
23 Bor, J, Brunelin, J, d'Amato, T, Costes, N, Suaud-Chagny, M-F, Saoud, M, et al. How can cognitive remediation therapy modulate brain activations in schizophrenia? An fMRI study. Psychiatry Res 2011; 192: 160–6.
24 Minzenberg, MJ, Laird, AR, Thelen, S, Carter, CS, Glahn, DC. Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Arch Gen Psychiatry 2009; 66: 811–22.
25 Bowie, CR, Reichenberg, A, Patterson, TL, Heaton, RK, Harvey, PD. Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms. Am J Psychiatry 2006; 163: 418–25.
26 McClure, MM, Bowie, CR, Patterson, TL, Heaton, RK, Weaver, C, Anderson, H, et al. Correlations of functional capacity and neuropsychological performance in older patients with schizophrenia: evidence for specificity of relationships? Schizophr Res 2007; 89: 330–8.
27 Twamley, EW, Burton, CZ, Vella, L. Compensatory cognitive training for psychosis: who benefits? Who stays in treatment? Schizophr Bull 2011; 37 (suppl 2): S55–62.
28 Pettersson-Yeo, W, Allen, P, Benetti, S, McGuire, P, Mechelli, A. Dysconnectivity in schizophrenia: where are we now? Neurosci Biobehav Rev 2011; 35: 1110–24.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *

CAPTCHA *

Skip to the audio challenge
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 32 *
Loading metrics...

Abstract views

Total abstract views: 95 *
Loading metrics...

* Views captured on Cambridge Core between 2nd January 2018 - 21st April 2018. This data will be updated every 24 hours.

  • Cited by 2
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Tripathi, Adarsh Kar, Sujita Kumar and Shukla, Rashmi 2018. Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies. Clinical Psychopharmacology and Neuroscience, Vol. 16, Issue. 1, p. 7.

    Ramsay, Ian S. Nienow, Tasha M. and MacDonald, Angus W. 2017. Increases in Intrinsic Thalamocortical Connectivity and Overall Cognition Following Cognitive Remediation in Chronic Schizophrenia. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 2, Issue. 4, p. 355.

    ×
  • Access

Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: Triple-blind trial

  • Ian S. Ramsay (a1), Tasha M. Nienow (a2), Matthew P. Marggraf (a3) and Angus W. MacDonald (a4)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response

Your details

Conflicting interests

Do you have any conflicting interests? *

Cancel
Confirm
×