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    Tripathi, Adarsh Kar, Sujita Kumar and Shukla, Rashmi 2018. Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies. Clinical Psychopharmacology and Neuroscience, Vol. 16, Issue. 1, p. 7.

    Ramsay, Ian S. Nienow, Tasha M. and MacDonald, Angus W. 2017. Increases in Intrinsic Thalamocortical Connectivity and Overall Cognition Following Cognitive Remediation in Chronic Schizophrenia. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 2, Issue. 4, p. 355.

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Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: Triple-blind trial

  • Ian S. Ramsay (a1), Tasha M. Nienow (a2), Matthew P. Marggraf (a3) and Angus W. MacDonald (a4)
Abstract
Background

Patients with schizophrenia have shown cognitive improvements following cognitive remediation, but the neuroplastic changes that support these processes are not fully understood.

 Aims

To use a triple-blind, placebo-controlled trial to examine neural activation before and after cognitive remediation or a computer skills training (CST) placebo (trial registration: NCT00995553)).

 Method

Twenty-seven participants underwent functional magnetic resonance imaging before and after being randomised to either cognitive remediation intervention or CST. Participants completed two variants of the N-back task during scanning and were assessed on measures of cognition, functional capacity, community functioning and symptoms.

 Results

We observed a group × time interaction in the left prefrontal cortex, wherein the cognitive remediation group showed increased activation. These changes correlated with improved task accuracy within the cognitive remediation group, whereas there was no relationship between changes in activation in untrained cognitive measures. Significant changes were not observed in other hypothesised areas for the cognitive remediation group.

 Conclusions

We replicated the finding that cognitive remediation increases left lateral prefrontal activation during a working memory task in patients with schizophrenia, suggesting this may be an important neural target for these types of interventions.
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Copyright
COPYRIGHT: © Royal College of Psychiatrists, 2017 
Corresponding author
Angus W. MacDonald, Department of Psychology, University of Minnesota, N219 Elliot Hall 75 E. River Rd, Minneapolis, MN 55455, USA. Email: angus@umn.edu
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Declaration of interest

None.

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References
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  • Cited by 2
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Tripathi, Adarsh Kar, Sujita Kumar and Shukla, Rashmi 2018. Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies. Clinical Psychopharmacology and Neuroscience, Vol. 16, Issue. 1, p. 7.

    Ramsay, Ian S. Nienow, Tasha M. and MacDonald, Angus W. 2017. Increases in Intrinsic Thalamocortical Connectivity and Overall Cognition Following Cognitive Remediation in Chronic Schizophrenia. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 2, Issue. 4, p. 355.

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Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: Triple-blind trial

  • Ian S. Ramsay (a1), Tasha M. Nienow (a2), Matthew P. Marggraf (a3) and Angus W. MacDonald (a4)
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