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New Treatments for Erectile Impotence

  • Alain Gregoire (a1)

Abstract

The range of interventions available for the treatment of erectile failure has increased in the past ten years. A significant development is intracavernosal injection of vasoactive drugs, but this treatment is far from ideal. Other, less invasive, pharmacological interventions are being investigated; as yet, none of these appear effective enough to have any significant clinical impact. External vacuum devices are a viable option for some patients, and penile prostheses have become increasingly sophisticated, although research examining their benefits has not. The range of available treatment methods and the growing complexity of the assessment for erectile problems demands an eclecticism of approach which can best be provided by multidisciplinary clinics specialising in sexual dysfunctions.

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Abozeid, M., Juenemann, K. P., Luo, J. A., et al (1987) Chronic papaverine treatment: the effect of repeated injections on the simian erectile response and penile tissue. Journal of Urology, 138, 1263.
Ambrosi, B., Bara, R., Travaglini, P., et al (1977) Study of the effects of bromocriptine on sexual impotence. Clinical Endocrinology, 7, 417421.
Asopa, R. & Williams, G. (1989) Use of the Correctaid device in the management of impotence. British Journal of Urology, 63, 546547.
Benassi-Benelli, A., Ferrari, F. & Pellegrini-Quarantotti, B. (1979) Penile erection induced by apormorphine and N-n-propylnorapomorphine in rats. Archives of International Psychodynamic Therapy, 242, 241247.
Bennett, A. H., Rivard, D. J., Blanc, R. P., et al (1986) Reconstructive surgery for vasculogenic impotence. Journal of Urology, 136, 599601.
Berendsen, H. H. G. & Gower, A. J. (1986) Opiate: androgen interactions in drug-induced yawning and penile erections in the rat. Neuroendocrinology, 42, 185190.
Berg, R., Mindus, P., Berg, G., et al (1984) Penile implants and erectile impotence: outcome and prognostic indicators. Scandinavian Journal of Urology and Nephrology, 18, 277282.
Brindley, G. S. (1983) Cavernosal alpha-blockade: a new technique for investigating and treating erectile impotence. British Journal of Psychiatry, 143, 332337.
Brindley, G. S. (1984) New treatment for priapism. Lancet, ii, 220221.
Brindley, G. S. (1986) Maintenance treatment of erectile impotence by cavernosal unstriated muscle relaxant injection. British Journal of Psychiatry, 149, 210215.
Cameron, L. & Woodruff, P. (1985) Cavernosal alpha blockade: a treatment for erectile impotence. British Journal of Psychiatry, 147, 107.
Charney, D. S., Heninger, G. R. & Sternberg, D. E. (1982) Assessment of alplu2adrenergic autoregulator function in humans: effects of oral yohimbine. Life Sciences, 30, 20332041.
Charney, D. S., Heninger, G. R., & Redmond, D. E. Jr (1983) Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine. Life Sciences, 33, 1929.
Cleeves, L. & Findley, L. J. (1987) Bromocriptine induced impotence in Parkinson's disease. British Medical Journal, 295, 367368.
Cole, M. (1985) Sex therapy – a critical appraisal. British Journal of Psychiatry, 147, 337351.
Collins, G. F. & Kinder, B. N. (1984) Adjustment following surgical implantation of a penile prosthesis: a critical overview. Journal of Sex and Marital Therapy, 10, 255271.
Costentin, J., Dubue, I. & Protais, P. (1983) Behavioural data suggesting the plurality of central dopamine receptors. In CNS Receptors – From Molecular Pharmacology to Behaviour (eds Mangel, P. & Defeudis, F. V.). New York: Raven Press.
De Amicis, L. A., Goldberg, D. C., Lopiccolo, J., et al (1985) Clinical follow-up of couples treated for sexual dysfunction. Archives of Sexual Behaviour, 14, 467489.
Fabbri, A., Jannini, E. A., Gnessi, L., et al (1989) Endorphine in male impotence: evidence for naltrexone stimulation of erectile activity in patient therapy. Psychoneuroendocrinology, 14, 103111.
Gee, W. F., McRoberts, J. W., Raney, J. O., et al (1974) The impotent patient: surgical treatment with penile prosthesis and psychiatric evaluation. Journal of Urology, 111, 4143.
Gerstenberger, D. L., Osbourne, D. & Furlow, W. L. (1979) Inflatable penile prosthesis: follow-up study of patient-partner satisfaction. Urology, 14, 583587.
Gessa, G. L., Paglietti, E. & Pellegrini-Quarantotti, B. (1979) Induction of copulatory behaviour in sexually inactive rats by naloxone. Science, 204, 203205.
Girdley, F. M., Bruskewitz, R. C., Feyzi, J., et al (1988) Intracavernous self-injection for impotence: a long-term therapeutic option? Experience in 78 patients. Journal of Urology, 140, 972974.
Goldstein, J. A. (1986) Erectile function and naltrexone. Annals of Internal Medicine, 105, 799.
Goldstein, A. & Hansteen, R. W. (1977) Evidence against involvement of endorphin in sexual arousal and orgasm in man. Archives of General Psychiatry, 34, 11791180.
Gregoire, A. (1990) Self-injection treatment for impotence. British Medical Journal, 300, 357.
Hauri, D. (1986) A new operative technique in vasculogenic erectile impotence. World Journal of Urology, 4, 237249.
Holmgren, B., Urba-Holmgren, R., Trucios, N., et al (1985) Association of spontaneous and dopaminergic-induced yawning and penile erections in rat. Pharmacology, Biochemistry and Behaviour, 11, 3135.
Ishii, N., Watanabe, H., Irisawa, C., et al (1989) Intracavernous injection of prostaglandin E1 for the treatment of erectile impotence. Journal of Urology, 141, 323325.
Journal of Urology (1981) Editorial comment, 126, 175.
Kaufman, J. J., Boxer, R. J., Boxer, B., et al (1981) Physical and psychological results of penile prosthesis: a statistical survey. Journal of Urology, 126, 173175.
Kebabian, J. W. & Calne, D. B. (1979) Multiple receptors for dopamine. Nature, 577, 9396.
Kiely, E. A., Ignotus, P. & Williams, G. (1987a) Penile function following intracavernosal injection of vasoactive agents or saline. British Journal of Urology, 59, 473476.
Kiely, E. A., Williams, G. & Goldie, L. (1987b) Assessment of the immediate and long-term effects of pharmacologically induced penile erections in the treatment of psychogenic and organic impotence. British Journal of Urology, 59, 164169.
Kramarsky-Binkhorst, S. (1978) Female partner perception of small carrion implant. Urology, 12, 545.
Lakin, M. M., Montague, D. K., Vanderbrug Medendorp, S., et al (1990) Intracavernous injection therapy: analysis of results and complications. Journal of Urology, 143, 11381141.
Lal, S., Ackman, D., Thavundayil, J. N., et al (1984) Effect of apomorphine, a dopamine receptor agonist, on penile tumescence in normal subjects. Neuro-Psychopharmacological and Biological Psychiatry, 8, 695699.
Lal, S., Labyea, E., Thavundayil, J. K., et al (1987) Apomorphine induced penile tumescence in impotent patients – preliminary findings. Neuro-Psychopharmacological and Biological Psychiatry, 11, 535542.
Lal, S., Tesfaye, Y., Thavundayil, J. K., et al (1989) Apomorphine: clinical studies on erectile impotence and yawning. Neuro-Psychopharmacological and Biological Psychiatry, 13, 329339.
Legros, J. J., Chiodera, P., Mormont, C., et al (1980) A psychoneuroendocrinological study of sexual impotence in patients with abnormal reaction to a glucose tolerance test. Advances in Biological Psychiatry, 5, 117124.
Levine, S. B., Althof, S. E., Turner, L. A., et al (1989) Side effects of self-administration of intracavernous papaverine and phetolamine for the treatment of impotence. Journal of Urology, 141, 5457.
Lewis, R. W., Puyau, F. A., & Bell, D. P. (1986) Another surgical approach for vasculogenic impotence. Journal of Urology, 136, 12101212.
LoPiccolo, J. & Stock, W. (1986) Treatment of sexual dysfunction. Journal of Consulting Clinical Psychology, 54, 158167.
Lue, T. F. (1988) Treatment of venogenic impotence. In Contemporary Management of Impotence and Infertility (eds Tanagho, E. A., Lue, T. F. & McClure, R. D.). Baltimore: Williams & Wilkins.
Lue, T. F. & McAninch, J. W. (1988) Priapism. In Contemporary Management of Impotence and Infertility (eds Tanagho, E. A., Lue, T. F. & McClure, R. D.). Baltimore: Williams & Wilkins.
Lydston, G. F. (1908) The surgical treatment of impotency. American Journal of Clinical Medicine, 15, 7173.
Martindale (1989) Naltrexone hydrochloride. The Extra Pharmacopea (29th edn), pp. 486487. London: Pharmaceutical Press.
Masters, W. E. & Johnson, V. E. (1970) Human Sexual Inadequacy. Boston: Little Brown & Co.
Mintz, J., O'Hare, K., O'Brien, C. P., et al (1974) Sexual problems with heroin addicts. Archives of General Psychiatry, 31, 700703.
Morales, A., Condra, M., Owen, J. A., et al (1988) Oral and transcutaneous pharmacological agents for the treatment of impotence. In Contemporary Management of Impotence and Infertility (eds. Tanagho, E. A., Lue, T. F. & McClure, R. D.). Baltimore: Williams & Wilkins.
Moul, J. W. & McLeod, D. G. (1986) Experience with the AMS 600 maleable penile prosthesis. Journal of Urology, 135, 929931.
Myers, B. & Baum, M. J. (1979) Facilitation by opiate antagonists of sexual performance in the male rat. Biochemical Behaviour, 10, 615618.
Nadig, P. W., Catesby-Ware, J. & Blumoff, R. (1986) Noninvasive device to produce and maintain an erection-like state. Urology, 11, 126131.
Padma-Nathan, H. & Goldstein, I. (1988) Arterial reconstruction. In Contemporary Management of Impotence and Infertility (eds Tanagho, E. A., Lue, T. F. & McClure, R. D.). Baltimore: Williams & Wilkins.
Price, L. H., Charney, D. S., & Heninger, G. R. (1984) Three cases of manic symptoms following yohimbine administration. American Journal of Psychiatry, 141, 12671268.
Reid, K., Morales, A., Harris, C., et al (1987) Double-blind trial of yohimbine in treatment of psychogenic impotence. Lancet, i, 421423.
Reynolds, B. S. (1977) Psychological treatment models and outcome results for erectile dysfunction: a critical review. Psychological Bulletin, 84, 12181238.
Riley, A. J. (1990) Erection-assisting devices. British Journal of Sexual Medicine, 17, 175177.
Riley, A. J., Goodman, R. E., Kellett, J. M., et al (1989) Double-blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sexual and Marital Therapy, 4, 1726.
Schlatter, E. K. E. & Lal, S. (1972) Treatment of alcoholism using Dent's oral apomorphine method. Quarterly Journal of Studies on Alcohol, 33, 430436.
Schramek, P., Dorninger, R., Waldhauser, M., et al (1990) Prostaglandin E1 in erectile dysfunction. British Journal of Urology, 65, 6871.
Scott, F. B., Byrd, G. J. & Karacan, I. (1979) Erectile impotence treated with an implantable inflatable prosthesis: five years of clinical experience. Journal of the American Medical Association, 241, 26092612.
Sidi, A. A., Cameron, J. S., Duffy, L. M., et al (1986) Intracavernous drug-induced erections in the management of male erectile dysfunction: experience with 100 patients. Journal of Urology, 135, 704706.
Sidi, A. A., Reddy, P. A. & Chen, K. K. (1988) Patient acceptance of and satisfaction with vasoactive intracavernous pharmacotherapy for impotence. Journal of Urology, 140, 293294.
Smith, A. D. (1981) Causes and classification of impotence. Urology Clinics of North America, 8, 7989.
Sotile, W. M. (1979) The penile prosthesis: a review. Journal of Sexual and Marital Therapy, 5, 90102.
Spycher, M. A., Hauri, D. (1986) The ultrastructure of erectile tissue in priapism. Journal of Urology, 135, 142147.
Stackl, W., Hasun, R. & Marberger, M. (1988) Intracavernous injection of prostaglandin E1 in impotent men. Journal of Urology, 140, 66.
Steege, J. F., Stout, A. L. & Carsen, C. C. (1986) Patient satisfaction in Scot and Small carrion penile implant recipients: a study of 52 patients. Archives of Sexual Behaviour, 15, 393399.
Strauss, B. (1950) Impotence from the psychiatric standpoint. British Medical Journal, i, 697704.
Susset, J. G., Tessier, C. D., Wincze, J., et al (1989) Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. Journal of Urology, 141, 13601363.
Talley, J. D. & Crawley, I. S. (1985) Transdermal nitrate, penile erection and spousal headache. Annals of International Medicine, 103, 804.
Thorner, M. O., McNeilly, A. S., Hagan, C., et al (1974) Long-term treatment of galactorrhoea and hypogonadism with bromocriptine. British Medical Journal, ii, 419422.
ViRAg, R. (1982) Intracavernous injection of papaverine for erectile failure. Lancet, ii, 928.
Wagner, G. & Green, R. (1981) Impotence. New York: Plenum.
Waiters, G. R., Keogh, E. J., Earle, C. M., et al (1988) Experience in the management of erectile dysfunction using the intracavernosal self-injection of vasoactive drugs. Journal of Urology, 140, 14171419.
Wespes, E. & Schulman, C. C. (1985) Venous leakage: surgical treatment of a curable cause of impotence. Journal of Urology, 133, 796798.
Wespes, E. & Schulman, C. C. (1988) Systemic complication of intracavernous papaverine injection in patients with venous leakage. Urology, 31, 114115.
Wiles, P. G. (1988) Successful non-invasive management of erectile impotence in diabetic men. British Medical Journal, 296, 161162.
Williams, G., Mulcahy, M. J. & Kiely, E. A. (1987) Impotence: treatment by autoinjection of vasoactive drugs. British Medical Journal, 295, 595596.
Williams, G., Mulcahy, M. J., Hartnell, G., et al (1988) Diagnosis and treatment of venous leakage: a curable cause of impotence. British Journal of Urology, 61, 151155.
Wright, J., Pbrreault, R. & Mathieu, M. (1977) The treatment of sexual dysfunction – a review. Archives of General Psychiatry, 34, 881890.
Zorgniotti, A. W. & Lefleur, R. S. (1985) Auto-injection of the corpus cavernosum with a vasoactive drug combination for vasculogenic impotence. Journal of Urology, 133, 3941.

New Treatments for Erectile Impotence

  • Alain Gregoire (a1)

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New Treatments for Erectile Impotence

  • Alain Gregoire (a1)
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