Skip to main content
×
×
Home

Paroxetine in social phobia/social anxiety disorder: Randomised, double-blind, placebo-controlled study

  • David Baldwin (a1), Julio Bobes (a2), Dan J. Stein (a3), Ingebor Scharwächter (a4) and Michel Faure (a5)...
Abstract
Background

Preliminary studies have suggested that paroxetine may be effective in social phobia/social anxiety disorder.

Aims

To assess the efficacy and tolerability of paroxetine in the acute (12-week) treatment of social phobia.

Method

Two-hundred and ninety patients with social phobia were assigned randomly to paroxetine (20–50 mg/day flexible dose) or placebo for 12 weeks of double-blind treatment. Primary efficacy outcomes were the Liebowitz Social Anxiety Scale (LSAS) total score (patient-rated) and the Clinical Global Impression (GGI) scale global improvement item. The secondary efficacy variables included CGI scale severity of illness score and the patient-rated Social Avoidance and Distress Scale.

Results

Paroxetine produced a significantly greater reduction in LSAS total score (mean change from baseline: –29.4 v. –15.6; P 0.001) and a greater proportion of responders (score $2 on CGI global improvement) (65.7% v. 32.4%; P < 0.001) compared with placebo at the end of the 12-week study period. Both primary efficacy variables were statistically significant compared with placebo from week 4 onwards. Paroxetine was generally well tolerated.

Conclusions

Paroxetine is an effective, well-tolerated treatment for patients with social phobia.

Copyright
Corresponding author
Dr David Baldwin, Mental Health Group, University of Southampton, Royal South Hants Hospital, Brintons Terrace, Southampton SO14 0YG. Tel: +44 (0)1703 825538; Fax: +44 (0)1703 234243; e-mail: dsbl@soton.ac.uk
References
Hide All
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM–IV). Washington, DC: APA.
Ballenger, J. C., Davidson, J. R. T., Lecrubier, Y., et al (1998) Consensus statement on social anxiety disorder. Journal of Clinical Psychiatry, 59 (suppl. 17), 5460.
Davidson, J. R. T. (1998) Pharmacotherapy of social anxiety disorder. Journal of Clinical Psychiatry, 59 (suppl. 17), 4751.
Davidson, J. R. T., Hughes, D. L., George, L. K., et al (1993) The epidemiology of social phobia. Findings from the Duke Epidemiologic Catchment Area study. Psychological Medicine, 23, 709718.
Guy, W. (1976) ECDEU Assessment Manual for Psychopharmacology, pp. 217222. Washington, DC: Department of Health. Education and Welfare.
Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of the Society of Clinical Psychology, 6, 278296.
Katzelnick, D. J., Kobak, K. A., Greist, J. H., et al (1995) Sertraline for social phobia: a double-blind, placebo-controlled, crossover study. American Journal of Psychiatry. 152, 13681371.
Lecrubier, Y., Bakker, A., Dunbar, G., et al (1997) A comparison of paroxetine, clomipramine and placebo in the treatment of panic disorder. Acta Psychiatrica Scandinavica, 95, 145152.
Liebowitz, M. R. (1987) Social phobia. Modern Problems in Pharmacopsychiatry, 22, 141173.
Magee, W. J., Eaton, W. W., Wittchen, H.-U., et al (1996) Agoraphobia, simple phobia and social phobia in the National Comorbidity Survey. Archives of General Psychiatry, 53, 159168.
Merikcangas, K. R. & Angst, J. (1995) Comorbidity and social phobia: evidence from clinical, epidemiologic, and genetic studies. European Archives of Psychiatry and Clinical Neurosciences, 244, 297303.
OECD [Centre for Educational Research and Innovation] (1996) Education at a Glance Analysis, vol. 68. Paris: Organization for Economic Cooperation and Development.
Schneier, F. R., Johnson, J., Hornig, C. D., at al (1992) Comorbidity and morbidity in an epidemiologic sample. Archives of General Psychiatry, 49, 282288.
Schneier, F. R., Garfinkel, R., Kennedy, B., et al (1996) Ondansetron in the treatment of panic disorder. Anxiety, 2, 199202.
Shear, M. K. & Beidel, D. C. (1998) Psychotherapy in the overall management for social anxiety disorder. Journal of Clinical Psychiatry, 59 (suppl. 17), 3946.
Sheehan, D. (1983) The Anxiety Disease, pp. 148149. New Work: Scribner.
Sheehan, D., Lecrubier, Y., Sheehan, K. H., et al (1998) The Mini-International Neuropsychiatrie Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM–IV and ICD–10. Journal of Clinical Psychiatry, 59 (suppl. 20), 2233.
Stein, M. B., Liebowitz, M. R., Lydiard, R. B., et al (1998) Paroxetine treatment of generalised social phobia. A randomised, double-blind, placebo-controlled study. Journal of the American Medical Association, 280, 708713.
Van Ameringen, M. Mancini, C. & Streiner, D. (1994) Sertraline in social phobia. Journal of Affective Disorders, 31, 141145.
Van Vliet, I. M., den Boer, J. A. & Westenberg, H. G. M. (1994) Psychopharmacological treatment of social phobia: a double-blind, placebo-controlled study with fluvoxamine. Psychopharmacology (Berlin), 115, 128134.
Wacker, H. R., Müllejans, R., Klein, K. H., et al (1992) Identification of cases of anxiety disorders and affective disorders in the community according to ICD–10 and DSM–III–R by using the Composite International Diagnostic Interview (CIDI). International Journal of Methods in Psychiatric Research, 2, 91100.
Watson, P. & Friend, R. (1969) Measurement of social-evaluative anxiety. Journal of Consulting and Clinical Psychology, 33, 448457.
Weiller, E., Bisserbe, J.-C., Boyer, P., et al (1996) Social phobia in general health care. An unrecognised undertreated disabling disorder. British Journal of Psychiatry, 168, 169174.
Wittthon, H.-U. & Beloch, E. (1996) The impact of social phobia on quality of life. International Clinical Psychopharmacology, II (suppl. 3), 1523.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Paroxetine in social phobia/social anxiety disorder: Randomised, double-blind, placebo-controlled study

  • David Baldwin (a1), Julio Bobes (a2), Dan J. Stein (a3), Ingebor Scharwächter (a4) and Michel Faure (a5)...
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *