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Pathological gambling and the treatment of psychosis with aripiprazole: case reports

  • Neil Smith (a1), Nathan Kitchenham (a1) and Henrietta Bowden-Jones (a1)
Summary

This paper details three case reports that suggest that pathological gambling activity may have been adversely modified following treatment for psychosis with the antipsychotic aripiprazole. These reports are discussed in the context of previous observations of the potential impact of aripiprazole on impulse control and the implications such observations could have for clinical practice and future research.

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Copyright
Corresponding author
Neil Smith, Central North West London NHS Trust, National Problem Gambling Clinic, 4th Floor, Soho Centre for Health and Care, 1 Frith Street, London W1D 3HZ, UK. Email: nsmith12@nhs.net
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Declaration of interest

The authors are employed in the NHS in a service providing help for problem gamblers.

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References
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1 Tavares, H, Zilberman, M, Hodgins, C, el-Guebaly, N. Comparison of craving between pathological gamblers and alcoholics. Alcohol Clin Exp Res 2005; 29: 1427–31.
2 Shaffer, HJ, LaBrie, R, Scanlan, KM, Cummings, TN. Pathological gambling among adolescents: Massachusetts Gambling Screen (MAGS). J Gambl Stud 1994; 10: 339–62.
3 Mouaffak, F, Gallarda, T, Bayle, FJ, Olie, JP, Baup, N. Worsening of obsessive-compulsive symptoms after treatment with aripiprazole. J Clin Psychopharmacol 2007; 27: 237–8.
4 Schlachetzki, JCM, Langosch, JM. Aripiprazole induced hypersexuality in a 24-year-old female patient with schizoaffective disorder? J Clin Psychopharmacol 2008; 28: 567–8.
5 Desarker, P, Das, A, Nizamie, SH. Aripiprazole-induced obsessive-compulsive disorder: a report of 2 cases. J Clin Psychopharmacol 2007; 27: 305–6.
6 Kodama, M, Hamamura, T. Aripiprazole-induced behavioural disturbance related to impulse control in a clinical setting. Int J Neuropsychopharmacol 2010; 13: 549–51.
7 Dodd, ML, Klos, KJ, Bower, JH, Geda, YE, Josephs, KA, Ahlskog, JE. Pathological gambling caused by drugs used to treat Parkinson disease. Arch Neurol 2005; 62: 1377–81.
8 Evans, AH, Strafella, AP, Weintraud, D, Stacy, M. Impulsive and compulsive behaviors in Parkinson's disease. Mov Disord 2009; 24: 1561–70.
9 Roxanas, MG. Pathological gambling and compulsive eating associated with aripiprazole. Aust N Z J Psychiatry 2010; 44: 291.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Pathological gambling and the treatment of psychosis with aripiprazole: case reports

  • Neil Smith (a1), Nathan Kitchenham (a1) and Henrietta Bowden-Jones (a1)
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