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Personalised intervention for people with depression and severe COPD

  • George S. Alexopoulos (a1), Dimitris N. Kiosses (a1), Jo Anne Sirey (a1), Dora Kanellopoulos (a1), Richard S. Novitch (a2), Samiran Ghosh (a3), Joanna K. Seirup (a3) and Patrick J. Raue (a3)...

Summary

Chronic obstructive pulmonary disease (COPD) is often complicated by depression and exemplifies the challenge in managing chronic illnesses that require active patient participation in care. In a clinical trial (NCT00151372), we compared a novel personalised intervention for depression and COPD (PID-C) targeting treatment adherence with treatment as usual (TAU). In 138 patients with major depression and severe COPD, PID-C led to a higher remission rate and a greater reduction in depressive symptoms and in dyspnoea-related disability than TAU over 28 weeks and 6 months after the last session. If replicated, PID-C may serve as a care model for patients with both depression and medical illnesses with a deteriorating course.

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Copyright

Corresponding author

George S. Alexopoulos, MD, Weill Cornell Medical Center, 21 Bloomingdale Road, White Plains, NY 10605, USA. Email: gsalexop@med.cornell.edu

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Declaration of interest

G.S.A. has received grant support from Forest Pharmaceuticals; has consulted to Hoffman-LaRoche, Lilly, Pfizer and Otsuka; and has served on speakers bureaux of AstraZeneca, Avenir, Forest, Merck, Novartis and Sunovion.

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References

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1 Lebowitz, BD, Pearson, JL, Schneider, LS, Reynolds, CF 3rd, Alexopoulos, GS, Bruce, ML, et al Diagnosis and treatment of depression in late life. Consensus statement update. JAMA 1997; 278: 1186–90.
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9 Alexopoulos, GS, Reynolds, CF 3rd, Bruce, ML, Katz, IR, Raue, PJ, Mulsant, BH, et al Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study. Am J Psychiatry 2009; 166: 882–90.
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Personalised intervention for people with depression and severe COPD

  • George S. Alexopoulos (a1), Dimitris N. Kiosses (a1), Jo Anne Sirey (a1), Dora Kanellopoulos (a1), Richard S. Novitch (a2), Samiran Ghosh (a3), Joanna K. Seirup (a3) and Patrick J. Raue (a3)...

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Personalised intervention for people with depression and severe COPD

  • George S. Alexopoulos (a1), Dimitris N. Kiosses (a1), Jo Anne Sirey (a1), Dora Kanellopoulos (a1), Richard S. Novitch (a2), Samiran Ghosh (a3), Joanna K. Seirup (a3) and Patrick J. Raue (a3)...
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