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Premorbid adjustment in first-episode non-affective psychosis: Distinct patterns of pre-onset course

  • Tor K. Larsen (a1), Svein Friis (a2), Ulrik Haahr (a3), Jan Olav Johannessen (a1), Ingrid Melle (a2), Stein Opjordsmoen (a2), Bjørn Rishovd Rund (a2), Erik Simonsen (a3), Per Vaglum (a2) and Thomas H. McGlashan (a4)...
Abstract
Background

Knowledge about premorbid development in psychosis can shed light upon theories about aetiology and schizophrenic heterogeneity, and form a basis for early detection initiatives.

Aims

To identify and validate patterns of premorbid functioning in first-episode psychosis.

Method

The Premorbid Adjustment Scale was used to examine 335 patients.

Results

Social and academic function constituted fairly independent dimensions. Cluster analysis identified groups varying both in level and course. Patients with a stable social course compared with a deteriorating one had a shorter duration of untreated psychosis, were older, had more friends and less negative symptoms. Good childhood academic function correlated with more education, more meaningful activities and better working memory. Patients with a stable academic course were older at admission.

Conclusions

Patterns of premorbid development suggest both neuro-developmental and neuroregressive pathways to illness.

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Copyright
Corresponding author
Tor K. Larsen, MD, Helse Stavanger HF, Psychiatric Clinic, Armauer Hansensv. 20, PO Box 8100, N-4068 Stavanger, Norway. Tel: 47 51 51 51 51; fax: 47 51 51 50 50; e-mail: tklarsen@online.no
Footnotes
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Declaration of interest

None. Funding detailed in Acknowledgements.

Footnotes
References
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Premorbid adjustment in first-episode non-affective psychosis: Distinct patterns of pre-onset course

  • Tor K. Larsen (a1), Svein Friis (a2), Ulrik Haahr (a3), Jan Olav Johannessen (a1), Ingrid Melle (a2), Stein Opjordsmoen (a2), Bjørn Rishovd Rund (a2), Erik Simonsen (a3), Per Vaglum (a2) and Thomas H. McGlashan (a4)...
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