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Prenatal exposure to tobacco and future nicotine dependence: population-based cohort study

  • Mina Rydell (a1), Sven Cnattingius (a2), Fredrik Granath (a2), Cecilia Magnusson (a3) and Maria Rosaria Galanti (a3)...

Abstract

Background

Maternal smoking during pregnancy may increase the risk of nicotine dependence, especially in girls, but data are conflicting and confounding by other familial factors cannot be ruled out.

Aims

To clarify the relationship between prenatal tobacco exposure and adolescent tobacco uptake and dependence in boys and girls respectively, while taking confounding factors into close consideration.

Method

We conducted a prospective longitudinal study, comprising 3020 Swedish youths followed from 11 to 18 years of age. Exposure and outcome information was elicited via self-administered parental and repeated youth questionnaires. Hazard ratios (HRs), odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated as measures of associations.

Results

Girls prenatally exposed to maternal tobacco use had a two-to threefold increased odds of experiencing a high number of withdrawal symptoms (OR = 2.83, 95% CI 1.68–4.87), craving for tobacco (OR = 2.04, 95% CI 1.28–3.32) and heavy tobacco use (five or more cigarettes or snus dips per day) (OR = 1.93, 95% CI 1.30–2.86). These associations were weaker among boys, and did not reach formal statistical significance. Associations between prenatal tobacco exposure and onset of regular tobacco use in both genders appeared to be mostly explained by parents' social position and postnatal smoking behaviour.

Conclusions

Prenatal exposure to tobacco is linked to an increased risk of nicotine dependence among adolescent girls.

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Copyright

Corresponding author

Mina Rydell, Karolinska Institutet, Department of Public Health Sciences, Division of Public Health Epidemiology, Norrbacka 7th floor, SE-17176 Stockholm, Sweden. Email: mina.rydell@ki.se

Footnotes

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This study was funded with grant 2008-0876 from the Swedish Council for Working Life and Social Research. The BROMS Cohort Study was funded with grant 345-2002-35 from the Swedish Research Council and by the Stockholm County Council. Study sponsors had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; or preparation, review or approval of the manuscript.

Declaration of interest

M.R.G. is responsible for the tobacco prevention activities carried out by the Department of Public Health Sciences on behalf of Stockholm County Council. F.G. participates in a study funded by Pfizer, aimed at studying the potential adverse birth outcomes of varenicline. This project is a part of fulfilling the US Food and Drug Administration/European Medicines Agency's requirement of post-marketing surveillance and has no link to the presented work.

Footnotes

References

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Prenatal exposure to tobacco and future nicotine dependence: population-based cohort study

  • Mina Rydell (a1), Sven Cnattingius (a2), Fredrik Granath (a2), Cecilia Magnusson (a3) and Maria Rosaria Galanti (a3)...

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Prenatal exposure to tobacco and future nicotine dependence: population-based cohort study

  • Mina Rydell (a1), Sven Cnattingius (a2), Fredrik Granath (a2), Cecilia Magnusson (a3) and Maria Rosaria Galanti (a3)...
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