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Prevalence of serum N-methyl-d-aspartate receptor autoantibodies in refractory psychosis

  • Katherine Beck (a1), John Lally (a1), Sukhwinder S. Shergill (a1), Michael A. P. Bloomfield (a1), James H. MacCabe (a1), Fiona Gaughran (a2) and Oliver D. Howes (a3)...
Summary

N-methyl-d-aspartate receptor (NMDA-R) autoantibodies have been reported in people with acute psychosis. We hypothesised that their presence may be implicated in the aetiology of treatment-refractory psychosis. We sought to ascertain the point prevalence of NMDA-R antibody positivity in patients referred to services for treatment-refractory psychosis. We found that 3 (7.0%) of 43 individuals had low positive NMDA-R antibody titres. This suggests that NMDA-R autoantibodies are unlikely to account for a large proportion of treatment-refractory psychosis.

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Copyright
Corresponding author
Oliver D. Howes, Institute of Psychiatry, Box 67, Camberwell, London SE5 8AF, UK. Email: oliver.howes@kcl.ac.uk
Footnotes
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These authors contributed equally to the work.

∗∗

Joint supervising authors.

This study was funded by a Medical Research Council (UK) grant to O.D.H. (grant number: MC-A656-5QD30) and the National Institute of Health Research Biomedical Research Council grant to King's College London.

Declaration of interest

F.G.: honoraria from Roche, BMS, Lundbeck and Sunovion; has a family member with professional links to Lilly and GSK. O.D.H.: investigator-initiated research funding from and/or advisory/speaker meetings organised by Astra-Zeneca, Eli Lilly, Jansenn, Lyden-Delta, Servier and Roche.

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References
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Prevalence of serum N-methyl-d-aspartate receptor autoantibodies in refractory psychosis

  • Katherine Beck (a1), John Lally (a1), Sukhwinder S. Shergill (a1), Michael A. P. Bloomfield (a1), James H. MacCabe (a1), Fiona Gaughran (a2) and Oliver D. Howes (a3)...
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