Skip to main content Accessibility help
×
×
Home

Risk of major adverse perinatal outcomes in women with eating disorders

  • Nadia Micali (a1), Emily Simonoff (a2) and Janet Treasure (a3)

Abstract

Background

Low birth weight, prematurity and higher miscarriage rates have previously been reported in women with eating disorders.

Aims

To determine whether women with a history of eating disorders are at higher risk of major adverse perinatal outcomes.

Methods

Adjusted birth weight, preterm delivery and miscarriage history were compared in those with a history of eating disorders (anorexia nervosa (n=171), bulimia nervosa (n=199) and both (n=82)) and those with other (n=1166) and no psychiatric disorders (n=10 636) in a longitudinal cohort study.

Results

The group with bulimia nervosa had significantly higher rates of past miscarriages (relative risk ratio 2.0, P=0.01) and the group with anorexia nervosa delivered babies of significantly lower birth weight than the general population (P=0.01), which was mainly explained by lower pre-pregnancy body mass index. Preterm delivery rates were comparable across groups.

Conclusions

Women with a history of eating disorders are at higher risk of major adverse obstetric outcomes. Antenatal services should be aware of this higher risk.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Risk of major adverse perinatal outcomes in women with eating disorders
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Risk of major adverse perinatal outcomes in women with eating disorders
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Risk of major adverse perinatal outcomes in women with eating disorders
      Available formats
      ×

Copyright

Corresponding author

Dr Nadia Micali, Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King's College London, Box 085, De Crespigny Park, London SE5 8AF, UK. Email: N.Micali@iop.kcl.ac.uk

Footnotes

Hide All

Declaration of interest

None. Funding detailed in Acknowledgements.

Footnotes

References

Hide All
Abraham, S. (1998) Sexuality and reproduction in bulimia nervosa patients over 10 years. Journal of Psychosomatic Research, 44, 491502.
Blais, M. A., Becker, A. E., Burwell, R. A., et al (2000) Pregnancy: outcome and impact on symptomatology in a cohort of eating-disordered women. International Journal of Eating Disorders, 27, 140149.
Brinch, M., Isager, T. & Tolstrup, K. (1988) Anorexia nervosa and motherhood: reproduction pattern and mothering behavior of 50 women. Acta Psychiatrica Scandinavica, 77, 611617.
Bulik, C. M., Sullivan, P. F., Fear, J. L., et al (1999) Fertility and reproduction in women with anorexia nervosa: a controlled study. Journal of Clinical Psychiatry, 60, 130135.
Cnattingius, S., Bergstrom, R., Lipworth, L., et al (1998) Prepregnancy weight and the risk of adverse pregnancy outcomes. New England Journal of Medicine, 338, 147152.
Ehrenberg, H. M., Dierker, L., Milluzzi, C., et al (2003) Low maternal weight, failure to thrive in pregnancy, and adverse pregnancy outcomes. American Journal of Obstetrics and Gynecology, 189, 17261730.
Franko, D. L., Blais, M. A., Becker, A. E., et al (2001) Pregnancy complications and neonatal outcomes in women with eating disorders. American Journal of Psychiatry, 158, 14611466.
George, A. & Waller, G. (2005) Motivators for smoking in women with eating disorders. European Eating Disorders Review, 13, 417423.
Golding, J., Pembrey, M. & Jones, R. (2001) ALSPAC – the Avon Longitudinal Study of Parents and Children. I. Study methodology. Paediatric and Perinatal Epidemiology, 15, 7487.
Jablensky, A., Morgan, V., Zubrick, S., et al (2005) Pregnancy, delivery and neonatal complications in a population cohort of women with schizophrenia and major affective disorders. American Journal of Psychiatry, 162, 7991.
John, U., Meyer, C., Rumpf, H.-J., et al (2006) Psychiatric comorbidity including nicotine dependence among individuals with eating disorders criteria in an adult general population sample. Psychiatry Research, 141, 7179.
Kaminsky, M., Goujard, J. & Rumeau-Roquette, C. (1973) Prediction of low birth weight and prematurity by a multiple regression analysis with maternal characteristics known since the beginning of pregnancy. International Journal of Epidemiology, 2, 195204.
Kraemer, H. C., Stice, E., Kazdin, A., et al (2001) How do risk factors work together? Mediators, moderators, and independent, overlapping, and proxy risk factors. American Journal of Psychiatry, 158, 848856.
Mitchell, J. E., Specker, S. M. & de Zwaan, M. (1991) Comorbidity and medical complications of bulimia nervosa. Journal of Clinical Psychiatry, 52 (suppl.), 1320.
Morgan, J. F., Lacey, J. H. & Chung, E. (2006) Risk of postnatal depression, miscarriage, and preterm birth in bulimia nervosa: retrospective controlled study. Psychosomatic Medicine, 68, 487492.
Sollid, C. P., Wisborg, K., Hjort, J., et al (2004) Eating disorder that was diagnosed before pregnancy and pregnancy outcome. American Journal of Obstetrics and Gynecology, 190, 206210.
Stewart, D. E., Raskin, J., Garfinkel, P. E., et al (1987) Anorexia nervosa, bulimia, and pregnancy. American Journal of Obstetrics and Gynecology, 157, 11941198.
Striegel-Moore, R., Franko, D. & Ach, E. (2006) Epidemiology of eating disorders: an update. In Annual Review of Eating Disorders (eds Wonderlich, S., Mitchell, J. E., de Zwaan, M., et al). pp. 6580. Radcliffe.
Van Hoeken, D., Seidell, J. & Hoek, H. (2003) Epidemiology. In Handbook of Eating Disorders (eds Treasure, J., Schmidt, U. & van Furth, E.), pp. 1134. Wiley.
Waugh, E., Bulik, C. M. (1999) Offspring of women with eating disorders. International Journal of Eating Disorders, 25, 123133.
Wolfe, H. M., Zador, I. E., Gross, T. L., et al (1991) The clinical utility of maternal body mass index in pregnancy. American Journal of Obstetrics and Gynecology, 164, 13061310.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Risk of major adverse perinatal outcomes in women with eating disorders

  • Nadia Micali (a1), Emily Simonoff (a2) and Janet Treasure (a3)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *