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Risk of stroke among patients with post-traumatic stress disorder: nationwide longitudinal study

  • Mu-Hong Chen (a1), Tai-Long Pan (a2), Cheng-Ta Li (a1), Wei-Chen Lin (a1), Ying-Sheue Chen (a1), Ying-Chiao Lee (a1), Shih-Jen Tsai (a1), Ju-Wei Hsu (a1), Kai-Lin Huang (a1), Chia-Fen Tsai (a1), Wen-Han Chang (a3), Tzeng-Ji Chen (a4), Tung-Ping Su (a5) and Ya-Mei Bai (a5)...
Abstract
Background

Previous evidence has shown positive associations between post-traumatic stress disorder (PTSD) and hypertension, dyslipidaemia and diabetes mellitus, which are all risk factors for stroke, but the role of PTSD in the subsequent development of stroke is still unknown.

Aims

To investigate the temporal association between PTSD and the development of stroke.

Method

Identified from the Taiwan National Health Insurance Research Database, 5217 individuals aged 18 years, with PTSD but with no history of stroke, and 20 868 age- and gender-matched controls were enrolled between 2002 and 2009, and followed up until the end of 2011 to identify the development of stroke.

Results

Individuals with PTSD had an increased risk of developing any stroke (hazard ratio (HR) 3.37, 95% CI 2.44–4.67) and ischaemic stroke (HR = 3.47, 95% CI 2.23–5.39) after adjusting for demographic data and medical comorbidities. Sensitivity tests showed consistent findings (any stroke HR = 3.02, 95% CI 2.13–4.28; ischaemic stroke HR = 2.89, 95% CI 1.79–4.66) after excluding the first year of observation.

Conclusions

Individuals with PTSD have an increased risk of developing any stroke and ischaemic stroke. Further studies are required to investigate the underlying mechanisms.

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Copyright
Corresponding author
Dr Ya-Mei Bai, Department of Psychiatry, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Road, Beitou District, Taipei 112, Taiwan. Email: ymbi@mail2000.com.tw
Footnotes
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These authors contributed equally to the work.

The study was supported by grant from the Taipei Veterans General Hospital (V103E10-001).

Declaration of interest

None.

Footnotes
References
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Risk of stroke among patients with post-traumatic stress disorder: nationwide longitudinal study

  • Mu-Hong Chen (a1), Tai-Long Pan (a2), Cheng-Ta Li (a1), Wei-Chen Lin (a1), Ying-Sheue Chen (a1), Ying-Chiao Lee (a1), Shih-Jen Tsai (a1), Ju-Wei Hsu (a1), Kai-Lin Huang (a1), Chia-Fen Tsai (a1), Wen-Han Chang (a3), Tzeng-Ji Chen (a4), Tung-Ping Su (a5) and Ya-Mei Bai (a5)...
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