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Selective serotonin reuptake inhibitor treatment in the UK: Risk of relapse or recurrence of depression

  • Ami J. Claxton (a1), Zhiming Li (a2) and Jan McKendrick (a3)

Abstract

Background

Patients with depression are often not prescribed antidepressants for an adequate period of time.

Aims

The impact of antidepressant prescribing patterns on the risk of relapse or recurrence of depression is examined.

Method

The Medi Plus UK Primary Care Database was used to identify patients treated for depression with a selective serotonin reuptake inhibitor (SSRI). Records were used to construct hierarchical prescription patterns (less than 120 days, switching/augmentation, upward titration, or stable use) as indicators for the occurrence of relapse or recurrence of depression.

Results

Patients with stable use experienced the lowest risk of relapse or recurrence. Factors significantly associated with increased risk include prior use of anxiolytic medications, more comorbid conditions and younger age.

Conclusions

The SSRI prescription pattern most consistent with recommended depression treatment guidelines was associated with the lowest risk of relapse or recurrence.

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Copyright

Corresponding author

Dr Ami J. Claxton, Global Health Outcomes Research, Eli Lilly and Company, Indianapolis, IN 46285, USA. Tel: 317-277-3494; Fax: 317-276-6026; e-mail: ami.claxton@lilly.com

Footnotes

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Declaration of interest

Funding provided by Eli Lilly and Company.

Footnotes

References

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Selective serotonin reuptake inhibitor treatment in the UK: Risk of relapse or recurrence of depression

  • Ami J. Claxton (a1), Zhiming Li (a2) and Jan McKendrick (a3)

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Selective serotonin reuptake inhibitor treatment in the UK: Risk of relapse or recurrence of depression

  • Ami J. Claxton (a1), Zhiming Li (a2) and Jan McKendrick (a3)
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