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Serum levels of P-selectin in men with high-functioning autism

  • Yasuhide Iwata (a1), Kenji J. Tsuchiya (a1), Sumiko Mikawa (a1), Kazuhiko Nakamura (a1), Yoshifumi Takai (a1), Shiro Suda (a1), Yoshimoto Sekine (a1), Katsuaki Suzuki (a1), Masayoshi Kawai (a1), Genichi Sugihara (a1), Hideo Matsuzaki (a2), Kenji Hashimoto (a3), Masatsugu Tsujii (a4), Toshiro Sugiyama (a5), Nori Takei (a6) and Norio Mori (a7)...
Summary

Immune dysfunction has been proposed as a mechanism for the pathophysiology of autistic-spectrum disorders. The selectin family of adhesion molecules plays a prominent role in immune/inflammatory responses. We determined the serum levels of three types of soluble-form selectin (sP, sL and sE) in 15 men with high-functioning autism and 22 age-matched healthy controls by enzyme-linked immunosorbent assay. Levels of sP-selectin and sL-selectin were significantly lower in patients than in controls. Furthermore, sP-selectin levels were negatively correlated with impaired social development during early childhood.

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Copyright
Corresponding author
Professor Nori Takei, The Osaka-Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan. Email: ntakei@hama-med.ac.jp
References
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Serum levels of P-selectin in men with high-functioning autism

  • Yasuhide Iwata (a1), Kenji J. Tsuchiya (a1), Sumiko Mikawa (a1), Kazuhiko Nakamura (a1), Yoshifumi Takai (a1), Shiro Suda (a1), Yoshimoto Sekine (a1), Katsuaki Suzuki (a1), Masayoshi Kawai (a1), Genichi Sugihara (a1), Hideo Matsuzaki (a2), Kenji Hashimoto (a3), Masatsugu Tsujii (a4), Toshiro Sugiyama (a5), Nori Takei (a6) and Norio Mori (a7)...
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