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South Westminster Schizophrenia Survey: Alcohol use and Its Relationship to Symptoms, Tardive Dyskinesia and Illness Onset

  • Peter J. Duke (a1), Christos Pantelis (a2) and Thomas R. E. Barnes (a3)
Abstract

In the context of a prevalence survey of schizophrenia in South Westminster, a questionnaire was administered to 271 patients to assess alcohol-related morbidity. In this epidemiologically based sample, the lifetime prevalence of alcohol abuse was 22.1 %. Compared with control patients matched for age and sex, these index cases had a significantly shorter duration of illness. A possible explanation is that drinking may mask the onset of schizophrenia, leading to a delay in diagnosis. The index cases also had significantly higher ratings for hallucinations and for hostility, anxiety and depression, and a greater number of disturbed types of behaviour. The highest levels of alcohol consumption were associated with more severe orofacial dyskinesia, suggesting that alcohol use may be an added risk factor for the development of tardive dyskinesia in some patients. The severity of akathisia was also related to alcohol use, and there were significant relationships between the subjective distress related to akathisia and the level of abuse. A possible interpretation is that alcohol had been used by patients with akathisia to alleviate the associated agitation and dysphoria.

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Alterman, A. I., Erdlen, D. L., Laporte, D. J., et al (1982) Effects of illict drug use in an in-patient psychiatric population. Addictive Behaviours, 7, 231242.
Baldessarini, R. J. & Davis, J. M. (1980) What is the best maintenance dose of neuroleptics in schizophrenia? Psychiatry Research, 3, 115122.
Ban, T. A. (1977) Alcoholism and schizophrenia: diagnostic and therapeutic considerations. Alcoholism: Clinical and Experimental Research, 2, 113117.
Barnes, T. R. E. (1989) A scale for rating drug-induced akathisia. British Journal of Psychiatry, 154, 486491.
Barnes, T. R. E. & Trauer, T. (1982) Reliability and validity of a tardive dyskinesia videotape rating technique. British Journal of Psychiatry, 140, 508515.
Bernadt, M. W. & Murray, R. M. (1986) Psychiatric disorder, drinking and alcoholism: what are the links? British Journal of Psychiatry, 148, 393400.
Campbell, P. G., Taylor, J., Pantelis, C., et al (1990) Studies of schizophrenia in a large mental hospital proposed for closure and in two halves of an inner London borough served by the hospital. In International Perspectives in Schizophrenia (ed. Weller, M. P. I.). London: John Libbey.
Cutting, J. (1978) A reappraisal of alcoholic psychoses. Psychological Medicine, 8, 285295.
Cutting, J. (1987) The phenomenology of acute organic psychosis: comparison with acute schizophrenia. British Journal of Psychiatry, 151, 324332.
Drake, R. E., Osher, F. C., Noordsy, D. L., et al (1990) Diagnosis of alcohol use disorders in schizophrenia. Schizophrenia Bulletin, 16, 5767.
Duke, P. J., Pantelis, C. & Barnes, T. R. E. (1991) South Westminster Schizophrenia Survey: substance abuse and its relationship to symptomatology. Biological Psychiatry, 29, 664.
Feighner, J. P., Rubins, E., Guze, S., et al (1972) Diagnostic criterion for use in psychiatric research. Archives of General Psychiatry, 26, 5762.
Flaum, M., Arndt, S. & Andreasen, N. C. (1990) The role of gender in studies of ventricle enlargement in schizophrenia: predominantly male effect. American Journal of Psychiatry, 147, 13271332.
Freed, E. X. (1975) Alcoholism and schizophrenia: the search for perspectives. Journal of Studies on Alcohol, 36, 853881.
Glass, I. B. (1989) Alcoholic hallucinosis: a psychiatric enigma-1. The development of an idea. 2. Follow-up studies. British Journal of Addiction, 84, 2941, 151–164.
Guy, W. (1976) ECDEU Assessment Manual for Psychopharmacology (US Department of Health, Education and Welfare Publications), pp. 76338. Rockville: National Institute for Mental Health.
Krawiecka, M., Goldberg, D. & Vaughn, M. (1977) A standardised psychiatric assessment scale for rating chronic psychotic patients. Acta Psychiatrica Scandinavica, 55, 299308.
Lucey, J. L. & Dinan, T. G. (1992) Orofacial dyskinesia and the alcohol dependence syndrome. Psychological Medicine, 22, 7983.
Lutz, E. G. (1976) Neuroleptic-induced akathisia and dystonia triggered by alcohol. Journal of the American Medical Association, 236, 24222423.
McCreadie, R. M. (1982) The Nithsdale schizophrenia survey. I. Psychiatric and social handicaps. British Journal of Psychiatry, 140, 582586.
McLellan, A. T., Druley, K. A. & Carson, J. E. (1978) Evaluation of substance abuse problems in a psychiatric hospital. Journal of Clinical Psychiatry, 39, 425430.
Pantelis, C., Taylor, J. & Campbell, P. (1988) The South Camden schizophrenia survey - An experience of community-based research. Bulletin of the Royal College of Psychiatrists, 12, 98101.
Schneier, F. R. & Siris, S. G. (1987) A review of psychoactive substance use and abuse in schizophrenia: patterns of drug choice. Journal of Nervous and Mental Disease, 175, 641652.
Selzer, M. L. (1971) The Michigan Alcohol Screening Test; the quest for a new diagnostic instrument. American Journal of Psychiatry, 127, 16531658.
Simpson, G. M. & Angus, J. W. S. (1970) A rating scale for extrapyramidal side-effects in drug-induced extrapyramidal disorders. Acta Psychiatrica Scandinavica, 212, 1119.
Soni, S. D. & Brownlee, M. (1991) Alcohol abuse in chronic schizophrenics: implications for management in the community. Acta Psychiatrica Scandinavica, 84, 272276.
Stockwell, T., Murphy, D. & Hodgson, R. (1983) The Severity of Alcohol Dependence Questionnaire: its use, reliability and validity. British Journal of Addiction, 78, 145155.
Wykes, T. & Sturt, E. (1986) The measurement of social behaviour in psychiatric patients: An assessment of the reliability and validity of the SBS schedule. British Journal of Psychiatry, 148, 112.
Zung, B. J. & Charalampous, K. D. (1975) Item analysis of the Michigan Alcohol Screening Test. Journal of Studies on Alcohol, 36, 127132.
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South Westminster Schizophrenia Survey: Alcohol use and Its Relationship to Symptoms, Tardive Dyskinesia and Illness Onset

  • Peter J. Duke (a1), Christos Pantelis (a2) and Thomas R. E. Barnes (a3)
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