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Spontaneous dyskinesia and parkinsonism in never-medicated, chronically ill patients with schizophrenia: 18-month follow-up

  • R. G. McCreadie (a1), R. Padmavati (a2), R. Thara (a2) and T. N. Srinivasan (a2)

Abstract

Background

Spontaneous dyskinesia and parkinsonism have been reported in never-medicated patients with schizophrenia but there has been no previous study of the natural history of these conditions.

Aims

To determine the prevalence of spontaneous dyskinesia and parkinsonism in a group of never-medicated, chronically ill patients with schizophrenia on two occasions separated by an 18-month interval.

Method

Dyskinesia was assessed by the Abnormal Involuntary Movements Scale using Schooler and Kane criteria for its presence; parkinsonism by the Simpson and Angus scale; and mental state by the Positive and Negative Syndrome Scale for schizophrenia.

Results

Thirty-seven patients were examined on two occasions. Nine (24%) had dyskinesia on both occasions, 12 (33%) on one occasion and 16 (43%) on neither occasion. Twenty-one (57%) had dyskinesia on at least one occasion. Thirteen patients (35%) had parkinsonism on at least one occasion.

Conclusions

Spontaneous dyskinesia and parkinsonism fluctuate over time. The former was found on at least one occasion in the majority of patients. It is an integral part ofthe schizophrenic disease process.

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Copyright

Corresponding author

Professor R. G. McCreadie, Crichton Royal Hospital, Dumfries DGI 4TG, UK. Tel: 01387 244000; fax 01387 257735; e-mail: rgmccreadie_crh@compuserve.com

Footnotes

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Declaration of interest

None.

Footnotes

References

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Spontaneous dyskinesia and parkinsonism in never-medicated, chronically ill patients with schizophrenia: 18-month follow-up

  • R. G. McCreadie (a1), R. Padmavati (a2), R. Thara (a2) and T. N. Srinivasan (a2)
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