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Structural and functional brain changes in delusional disorder

  • Victor Vicens (a1), Joaquim Radua (a2), Raymond Salvador (a3), Maria Anguera-Camós (a3), Erick J. Canales-Rodríguez (a3), Salvador Sarró (a3), Teresa Maristany (a4), Peter J. McKenna (a3) and Edith Pomarol-Clotet (a3)...
Abstract
Background

Delusional disorder has been the subject of very little investigation using brain imaging.

Aims

To examine potential structural and/or functional brain abnormalities in this disorder.

Method

We used structural imaging (voxel-based morphometry, VBM) and functional imaging (during performance of the n-back task and whole-brain resting connectivity analysis) to examine 22 patients meeting DSM-IV criteria for delusional disorder and 44 matched healthy controls.

Results

The patients showed grey matter reductions in the medial frontal/anterior cingulate cortex and bilateral insula on unmodulated (but not on modulated) VBM analysis, failure of de-activation in the medial frontal/anterior cingulate cortex during performance of the n-back task, and decreased resting-state connectivity in the bilateral insula.

Conclusions

The findings provide evidence of brain abnormality in the medial frontal/anterior cingulate cortex and insula in delusional disorder. A role for the former region in the pathogenesis of delusions is consistent with several other lines of evidence.

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Copyright
Corresponding author
Joaquim Radua, MD, PhD, FIDMAG Germanes Hospitalàries, C/Dr Antoni Pujadas 38-C, 08830 Sant Boi de Llobregat, Barcelona, Spain. Email: jradua@fidmag.com
Footnotes
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Joint last authors.

Declaration of interest

None.

Footnotes
References
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Structural and functional brain changes in delusional disorder

  • Victor Vicens (a1), Joaquim Radua (a2), Raymond Salvador (a3), Maria Anguera-Camós (a3), Erick J. Canales-Rodríguez (a3), Salvador Sarró (a3), Teresa Maristany (a4), Peter J. McKenna (a3) and Edith Pomarol-Clotet (a3)...
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