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A Study of Association and Linkage of ABO Blood Types and Primary Affective Disorder

Published online by Cambridge University Press:  29 January 2018

Vasantkumar L. Tanna  and
George Winokur
Vasantkumar L. Tanna
Affiliation:
Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, St. Louis, Missouri 63110
George Winokur
Affiliation:
Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, St. Louis, Missouri 63110
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Extract

The demonstration of either the association of a genetic marker and primary affective disorder, or linkage between a genetic marker and primary affective disorder would provide incontrovertible evidence for a genetic factor in primary affective disorder. Disease association and linkage are two separate processes. Linkage is said to occur if two genes, each responsible for a separate trait, are on the same chromosome and are close enough together that they assort in a dependent fashion. In any single family the physical proximity of two genes on the same chromosome makes it likely that the characteristics of both genes will be found in a single individual. Association, on the other hand, occurs when two genetically separate traits have a non-random occurrence in a population. Association of a disease with a specific marker may occur fleetingly on the basis of linkage. This kind of association occurs only for a few generations, so that when enough generations have passed and enough crossing over has occurred between chromosomes the association disappears. Therefore, linkage produces no permanent association in the population, but may only be found within the family. The mechanism of association is, therefore, not that of linkage, but may be more likely explained by pleiotropic effects of a single gene.

Information

Type
Research Article
Information
The British Journal of Psychiatry , Volume 114 , Issue 514 , September 1968 , pp. 1175 - 1181
Copyright
Copyright © Royal College of Psychiatrists, 1968 

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