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Suicide in psychiatric hospital in-patients

Risk factors and their predictive power

Published online by Cambridge University Press:  02 January 2018

John Powell
Affiliation:
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford
John Geddes*
Affiliation:
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford
Jonathan Deeks
Affiliation:
ICRF/NHS Centre for Statistics in Medicine, Institute of Health Sciences, Headington, Oxford
Michael Goldacre
Affiliation:
FFHPM, Unit of Health-Care Epidemiology, University of Oxford
Keith Hawton
Affiliation:
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford
*
Dr John Geddes, Warneford Hospital, Oxford OX3 7JX. Tel: 01865 226480, fax: 01865 793101, e-mail: john.geddes@psych.ox.ac.uk
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Abstract

Background

Psychiatric hospital inpatients are known to be at high risk of suicide, yet there is little reliable knowledge of risk factors or their predictive power.

Aims

To identify risk factors for suicide in psychiatric hospital in-patients and to evaluate their predictive power in detecting people at risk of suicide.

Method

Using a case–control design, 112 people who committed suicide while in-patients in psychiatric hospitals were compared with 112 randomly selected controls. Univariate analysis and multivariate analyses were used to estimate odds ratios and adjusted likelihood ratios.

Results

The rate of suicide in psychiatric in-patients was 13.7 (95% CI 11.7–16.1) per 10 000 admissions. There were five predictive factors with likelihood ratios >2, following adjustment: planned suicide attempt, 4.1; actual suicide attempt, 4.9; recent bereavement, 4.0; presence of delusions, 2.3; chronic mental illness, 2.2; and family history of suicide, 4.6. On this basis, only two of the patients who committed suicide had a predicted risk of suicide above 5%.

Conclusions

Although several factors were identified that were strongly associated with suicide, their clinical utility is limited by low sensitivity and specificity, combined with the rarity of suicide, even in this high-risk group.

Type
Papers
Copyright
Copyright © 2000 The Royal College of Psychiatrists 

Psychiatric hospital in-patients are known to be at high risk of suicide (Reference ApplebyAppleby, 1992). The National Confidential Inquiry into Suicide and Homicide by People with Mental Illness has identified in-patients as a priority group for whom service recommendations are most required, and has recommended that the risk assessment skills of clinical staff should be strengthened (Reference Appleby, Shaw and AmosAppleby et al, 1999a ). There is a need to identify more clearly the factors that are associated with suicide among in-patients. However, suicidal behaviour is difficult to predict (Reference HawtonHawton, 1987; Reference GeddesGeddes, 1999), and the risk factors in in-patients are not necessarily the same as the risk factors for suicide in other population groups. Uncontrolled studies of in-patient suicides cannot quantify such risk factors and there have been few case-control studies (Reference Modestin, Zarro and WaldvogelModestin et al, 1992; Reference Read, Thomas and MellsopRead et al, 1993; Reference Roy and DraperRoy & Draper, 1995; Reference Sharma, Persad and KuenemanSharma et al, 1998). We report a study designed to identify potential risk factors and to assess their clinical utility in the prediction of suicide.

METHOD

Identification of subjects and controls

Using the Oxford Record Linkage Study (ORLS) (Reference Goldacre, Simmons and HendersonGoldacre et al, 1988) we identified all the people who died while patients in psychiatric hospitals in the counties of Oxfordshire, Berkshire, Buckinghamshire and Northamptonshire between 1963 and 1992. We did this by linking death certificates to abstracts of records of psychiatric in-patient care. This enabled us to identify not only the deaths that occurred in psychiatric hospitals, but also those that occurred off the hospital site, of people who were in-patients at the time of their death. The records from two hospitals were excluded (one hospital had not recorded any cases of deaths of in-patients on the ORLS and the other had destroyed all medical records of patients who died before 1988). Any deaths occurring more than a year after admission were excluded, as this group was not considered to be representative of acute psychiatric admissions. The death certificates and coroners' records were examined to determine the cases of suicide. We included as suicides, cases where the coroner's verdict was suicide, or undertermined cause (open verdict), in line with conventional practice (Reference Blain and DonaldsonBlain & Donaldson, 1995). The causes of death were checked from examination of clinical records.

Using the ORLS, control subjects were randomly selected by computer from psychiatric hospital in-patients admitted to the same hospitals in the same period who had not committed suicide. As there are no reliably known risk factors for suicide in in-patients in psychiatric hospitals, controls were unmatched other than for the year of admission. Patients with dementia admitted for respite care were excluded from the control group as they were not considered to be representative of acute psychiatric admissions.

Data collection

Permission to examine clinical records was given by the responsible consultant psychiatrists and clinical directors. Case notes were obtained from medical records departments. Clinical and social data were recorded from the ORLS database and from examination of case notes by one researcher (J.P.), using a 74-item questionnaire which incorporated characteristics previously shown or postulated to be factors associated with subsequent suicide (Reference ApplebyAppleby, 1992). These factors were operationally defined for the purposes of the study. To measure the degree of suicidal ideation, we developed a four-point scale on which patients were rated (on the evidence of their case notes) as having: no suicidal ideation; some suicidal ideas but no plan; a plan, but which was not acted upon; an act of self-harm either leading to, or during, admission.

The questionnaire was developed in a pilot study. The OPCRIT computerised diagnostic classification questionnaire (Reference McGuffin, Farmer and HarveyMcGuffin et al, 1991) was completed for all subjects, in addition to the clinical diagnosis recorded from the case notes. Data were recorded anonymously and transferred to a spreadsheet for analysis. It was not feasible for the rater to be blind to whether a subject was a case or a control, because this would have meant excluding important case-note material from the study. Ethical approval for the study was obtained from the local ethics committee.

Statistical analysis

Risk factor analysis

Descriptive analyses were carried out using SPSS (SPSS, 1997) and EPI-INFO (Reference Dean, Dean and CoulombierDean et al, 1995). Univariate and multivariate analyses were carried out using logistic regression with EGRET and STATA computer software (StataCorp, 1999; Statistics and Epidemiology Research Corporation, 1991). Factors that were statistically significantly associated with suicide in the univariate analysis were adjusted for the presence of suicidal ideation, which was strongly associated with suicide. Results are reported as univariate and multivariate odds ratios with 95% confidence intervals (CIs).

Likelihood ratio analysis

To estimate the clinical usefulness of the risk factors that were identified, we calculated likelihood ratios (LRs) for the variables that were associated with suicide following adjustment for suicidal ideation. LRs express the predictive value of each risk factor by comparing the probability that an individual who committed suicide would have that feature, compared with a control. LRs >1 indicate increased risk of suicide, LRs <1 indicate evidence against suicide; and more extreme values indicate stronger evidence.

Bayes' theorem states that the post-test odds of a condition, given the presence of a risk factor, can be found by multiplication of pre-test odds by the appropriate LR for that risk factor. Direct application of the LRs from more than one risk factor could be achieved by using extensions of Bayes' theorem such as:

\batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \[\ \mathrm{post-test\ odds}=\mathrm{LR}_{1}{\times}\mathrm{LR}_{2}{\times}{\ldots}{\times}\mathrm{LR}_{\mathrm{n}}{\times}\mathrm{pretest\ odds}\ \] \end{document}

However, such an approach has been termed ‘naïve’ or ‘idiot's Bayes’ (Reference FeinsteinFeinstein, 1977), as it does not account for the double counting of evidence from related risk factors. In practice, it typically overcounts diagnostic or predictive evidence and produces over-predictive models. A multivariate method to adjust for such confounding while preserving expression of the results in terms of LRs has been developed (Reference Spiegelhalter and Knill-JonesSpiegelhalter & Knill-Jones, 1984). Noting that the ‘naïve Bayes’ model can be written in terms of a sum of log likelihood ratios (LLRi):

\batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \[\ \mathrm{post-test\ log\ odds}=\mathrm{LLR}_{1}+\mathrm{LLR}_{2}+{\ldots}+\mathrm{LLR}_{\mathrm{n}}+\mathrm{pretest\ log\ odds}\ \] \end{document}

the confounding can be adjusted for by ‘shrinking’ each of the LLRis by factors Si:

\batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \[\ \mathrm{post-test\ log\ odds}=(\mathrm{S}_{1}{\times}\mathrm{LLR}_{\mathrm{i}})+(\mathrm{S}_{2}{\times}\mathrm{LLR}_{2})+{\ldots}+(\mathrm{S}_{\mathrm{n}}{\times}\mathrm{LLR}_{\mathrm{n}})+\mathrm{pretest\ log\ odds}\ \] \end{document}

Estimates of Si are obtained by logistic regression, and the adjusted LRs can be obtained by back-transformation. Such a model does not account for any interaction of diagnostic elements, solely confounding. A reduced multivariate model was produced by retaining only risk factors with adjusted LRs of 2 or more from the odds ratios logistic regression. Using these with the baseline suicide rate for in-patients allowed us to estimate the post-test probabilities of the predictor variables.

RESULTS

In the study period there were 117 deaths of psychiatric hospital in-patients in which a suicide or open verdict was given by the coroner. The estimated suicide rate was 13.7/10 000 admissions (95% CI 11.7-16.1). When the medical case notes were examined, it was found that in two cases an open verdict had been recorded in circumstances other than suicide, and that in three further cases the act of suicide had taken place immediately prior to admission to hospital (two concealed overdoses) or immediately following discharge, leaving 112 identified cases of in-patient suicide. Case notes were found for 97 patients (87%). The characteristics of the in-patient suicides are summarised in Table 1. Case notes were found for 90 of 112 controls (80%).

Table 1 Characteristics of people who committed suicide while in in-patient care

Men n=47 (%) Women n=50 (%) All n=97 (%)
Mean age (years) (s.d.) 43.3 (14.6) 46.8 (15.1) 45.1 (14.9)
Coroner's verdict
Suicide 25 (53) 27 (54) 52 (54)
Open 22 (47) 23 (46) 45 (46)
Day of week of suicide
Monday 5 (11) 10 (20) 15 (15)
Tuesday 9 (19) 4 (8) 13 (13)
Wednesday 6 (13) 3 (6) 9 (9)
Thursday 6 (13) 5 (10) 11 (11)
Friday 3 (6) 8 (16) 11 (11)
Saturday 8 (17) 9 (18) 17 (18)
Sunday 10 (21) 11 (11) 21 (22)
Time of day
08.00-12.00 10 (21) 17 (34) 27 (28)
12.00-16.00 10 (21) 10 (20) 20 (21)
16.00-20.00 3 (6) 5 (10) 8 (8)
20.00-24.00 4 (9) 6 (12) 10 (10)
24.00-04.00 4 (9) 6 (12) 10 (10)
04.00-08.00 3 (6) 3 (6) 6 (6)
Unknown 9 (19) 5 (12) 14 (14)
Method of suicide
Drowning 8 (17) 23 (46) 31 (32)
Hanging 8 (17) 7 (14) 15 (15)
Hit by train 9 (19) 4 (8) 13 (13)
Jumping from height 3 (6) 7 (14) 10 (10)
Overdose 4 (9) 7 (14) 11 (11)
Carbon monoxide 7 (15) 0 7 (7)
Other suffocation 4 (9) 0 4 (4)
Cut throat 2 (4) 0 2 (2)
Burning 1 (2) 0 1 (1)
Not recorded 1 (2) 2 (4) 3 (3)
Location of suicide
Within hospital site 11 (23) 14 (28) 25 (26)
Outside hospital site 36 (77) 36 (72) 72 (74)
On leave 34 (72) 36 (72) 70 (72)

Characteristics of the suicides

As shown in Table 1, more suicides occurred at the weekend. However, this excess was reduced from 61% to 15% when patients officially on weekend leave were excluded. Seventy-two per cent (n=70) of suicides of in-patients took place outside the hospital site; 63% of these patients were absent without leave. The most common method of suicide was drowning, with 28 drownings in rivers or lakes and three in baths on the ward. More men than women used violent methods, such as being hit by a train, or cutting or burning themselves; men were also more likely to use carbon monoxide or suffocation. The number of suicides by overdose was small (11%, n=11). Twenty-six per cent (n=25) of the in-patients not on leave were on formal nursing observations at the time of suicide, and two in-patients were under continuous observation. One of these two jumped through a window and deliberately cut his neck with the broken glass, the other ran to a railway line and was hit by a train.

Comparison of cases and controls

Univariate analyses comparing potential risk factors between cases and controls are shown in Table 2. The strongest risk factor for suicide was suicidal thoughts or acts prior to admission (as recorded in the case notes), and there was a ‘dose-response’ between the level of suicidal thoughts or acts and the degree of risk (likelihood ratio statistic for trend 53.71, 1 d.f., P<0.001). Patients who had harmed themselves either before or during admission were much more likely to commit suicide than control patients (OR 14.3; 95% CI 6.4-31.8). Other factors that remained significantly associated with suicide, after adjustment for the degree of suicidal thoughts or acts, were: recent bereavement (death of significant person in previous 12 months); presence of delusions; hopelessness; previous self-harm (before the index episode); chronic mental illness of over five years' duration (excluding diagnosis of personality disorder); previous admission to psychiatric hospital; and history of suicide in a first-degree relative. Patients with current drug or alcohol abuse were less likely to kill themselves.

Table 2 Case-control comparisons of possible risk factors for in-patient suicide

Risk factor Cases (%) Controls (%) OR (95% CI) P Adjusted OR (95% CI) (adjusted for presence of suicidal ideation)
Male 47/97 (48) 45/90 (50) 1.0 (0.6-1.9) 0.8
Mean age (s.d.) 45.1 (14.9) 41.7 (15.5) -
Age <45 years 51/97 (53) 34/90 (38) 1.8 (1.0-3.3) 0.04
Recent bereavement 12/94 (13) 4/90 (4) 3.2 (1-10.2) 0.06 4.5 (1.2-16.8)
Relationship difficulties 31/94 (33) 29/90 (32) 0.9 (0.5-1.5) 0.8
Recent other life event 3/94 (3) 5/90 (6) 0.6 (0.1-2.4) 0.7
Depressed mood 78/97 (80) 51/90 (57) 3.1 (1.6-6.0) 0.002 1.5 (0.7-3.3)
Angry or irritable 5/97 (5) 9/90 (10) 0.4 (0.1-1.5) 0.17
Delusions 34/96 (35) 14/90 (16) 3.0 (1.5-6.0) 0.002 2.9 (1.3-6.6)
Hallucinations 15/96 (16) 12/90 (13) 1.2 (0.5-2.7) 0.7
Hopelessness 47/94 (50) 15/90 (17) 5.0 (2.5-10.0) <0.001 2.3 (1.1-5.2)
Worthlessness or guilt 44/94 (47) 19/90 (21) 3.3 (1.7-6.3) <0.001 1.9 (0.9-4.0)
Suicidal thoughts
None (baseline) 23/97 (24) 68/90 (76) 1 -
Some ideas, no plan 17/97 (18) 10/90 (11) 5.0 (2-12.5) -
Plan, not acted upon 4/97 (4) 1/90 (1) 11.8 (1.3-111.3) -
Act of self-harm either leading to, or during, admission 53/97 (55) 11/90 (12) 14.3 (6.4-31.8) <0.001 -
Evidence of poor relationship with staff 11/96 (12) 18/90 (20) 0.8 (0.5-1.2) 0.3
On continuous observation during admission 2/96 (2) 0/90 (0) - 0.17
Previous self-harm (not including acts leading to or during index admission) 52/97 (54) 23/90 (26) 3.4 (1.8-6.3) <0.001 2.2 (1.1-4.5)
Chronic mental illness (> 5 years) 27/97 (28) 13/90 (14) 2.7 (1.5-5.1) 0.002 2.9 (1.4-6.2)
One or more previous admission 77/97 (79) 57/90 (63) 2.3 (1.2-4.3) 0.02 2.5 (1.2-5.5)
Previously detained under MHA 24/97 (25) 18/90 (20) 1.3 (0.7-2.6) 0.4
Previous diagnosis of schizophrenia 29/97 (30) 16/90 (18) 2.0 (1.0-4.0) 0.06 1.8 (0.8-4.2)
Previous diagnosis of depression 59/97 (61) 38/90 (42) 2.0 (1.1-3.5) 0.07
Previous diagnosis of personality disorder 9/97 (9) 12/90 (13) 0.7 (0.2-1.8) 0.4
Chronic physical illness 6/97 (6) 7/90 (8) 0.8 (0.3-2.4) 0.7
Extrapyramidal side-effects 3/95 (3) 2/90 (2) 0.9 (0.7-1.2) 0.7
First-degree relative commited suicide 12/94 (13) 3/89 (3) 4.2 (1.1-15.4) 0.03 5.0 (1.2-21.7)
First-degree relative with psychiatric illness 36/94 (38) 25/89 (28) 1.6 (0.9-3.0) 0.14
No educational qualifications 49/95 (52) 59/88 (67) 1.8 (0.9-3.9) 0.4
Single 29/97 (30) 21/84 (25) 1.1 (0.6-1.9) 0.8
Living alone 22/96 (23) 23/90 (26) 0.9 (0.4-1.7) 0.7
Unemployed 24/96 (25) 30/90 (33) 0.7 (0.4-1.3) 0.2
Has dependents 32/96 (33) 32/90 (36) 0.9 (0.5-1.7) 0.8
Current drug abuse 3/95 (3) 14/90 (16) 0.2 (0.0-0.6) 0.008 0.3 (0.1-1.4)
Current alcohol abuse 6/95 (6) 25/90 (28) 0.2 (0.1-0.5) <0.001 0.2 (0.1-0.5)
Conviction or caution for any offence 6/95 (6) 20/90 (22) 0.2 (0.1-0.6) 0.003 0.6 (0.2-1.6)
Prison sentence for any offence 1/95 (1) 13/90 (14) 0.1 (0.0-0.5) 0.008 0.2 (0.0-0.7)

Likelihood ratios

The crude LRs (with 95% CI) and LRs adjusted for the variables that were positively associated with suicide, and the post-test probabilities of each predictor using the observed pretest probability of 13.7 per 10 000 (0.137%) are presented in Table 3. The final model (including factors with adjusted LRs >2) included five predictors: recent bereavement, presence of delusions, suicidal ideation, chronic mental illness and a family history of suicide. In principle, these LRs can be used sequentially. For example, a patient with all five predictors would have a post-test odds of committing suicide of (0.137/100-0.137)×4.9×3.9×2.2×2.2×4.6=0.60, or a probability of suicide of 37%. Only one patient in the data set had all five risk factors.

Table 3 Likelihood ratios and post-test probabilities of the factors predictive of in-patient suicide

Risk factor Crude likelihood ratio (95% CI) Adjusted likelihood ratio (ALR)1 Final model likelihood ratio (FMLR) Post-test probability (using FMLR)
Suicidal thoughts
None (baseline) 0.3 (0.2-0.5) 0.4 0.3
Some ideas, no plan 1.6 (0.8-3.2) 1.5 1.6 0.002
Plan, not acted upon 3.7 (0.6-24.5) 3.1 4.1 0.006
Act of self-harm either leading to, or during, admission 4.5 (2.6-8.1) 3.7 4.9 0.007
Recent bereavement 2.9 (1.0-8.2) 5.3 3.9 0.006
Depressed mood 1.4 (1.2-1.8) 1.0
Delusions 2.3 (1.4-4.0) 2.3 2.2 0.003
Hopelessness 3.0 (1.9-5.0) 1.8
Worthlessness or guilt 2.2 (1.4-3.5) 1.3
Previous self-harm (not including acts leading to or during index admission) 2.1 (1.4-3.2) 1.6
Chronic mental illness (>5 years) 1.9 (1.1-3.5) 1.9 2.2 0.003
One or more previous admission 1.3 (1.0-1.5) 1.2
First-degree relative commited suicide 3.8 (1.2-12.2) 3.3 4.6 0.007

Assuming a notional level of ‘high risk’ as being greater than a 5% probability of suicide, the model predicted the cases as shown in Table 4. This table demonstrates that the model is of low sensitivity: only 297 (2%) of patients who committed suicide would have been identified as having a >5% risk of suicide. Twenty-seven per cent (26/97) of the patients who committed suicide had predicted risks of suicide greater than 1%, as did 1% (1/90) of the controls. The estimated median level of risk of suicide in the patients committing suicide was less than 0.5%.

Table 4 Risk of suicide in the psychiatric in-patients on admission: characteristics of the final model of factors predictive of suicide.

Risk of suicide Cases n (%) Controls n (%)
> 5% 2 (2) 0
> 1%≤5% 24 (25) 1 (1)
≤ 1% 71 (73) 89 (99)
97 90

If a 5% risk of suicide is considered to be clinically important, then the present data set would suggest that a patient with any three (or delusions plus chronic mental illness plus two others) or more of the five predictors should be considered to be at reasonably high risk. Patients with two (or delusions plus chronic illness plus one other) or more factors have risks of suicide greater than 1%.

DISCUSSION

Methodological considerations

In this study of potential risk factors for suicide in psychiatric patients we achieved a satisfactory overall case note retrieval rate (84%), which makes bias as a result of lost or destroyed case notes unlikely. All suicide cases were confirmed as such by examination of clinical records and death certificates, but some cases could have been missed if the coroners' verdicts were other than suicide or open. Our data on inpatient status were obtained from the ORLS. If a hospital admission was not recorded, then these cases would have been missed, but this would not have biased our findings.

One weakness of the study is that the rating of the presence of risk factors was not blind to case-control status. However, blinding would have been difficult to achieve: the last entry in all sets of case notes would have to have been removed, in addition to any reference to the suicide - including the writing of ‘deceased’ on the cover of the notes. The main measures used to avoid observer bias were the prior statement of the putative risk factors of interest, and the use of specific criteria for defining exposure to a potential risk factor.

Another limitation is that the identification of risk factors largely relied on criteria recorded in case notes. We cannot determine how accurate or complete these were, but it is likely that there was a degree of misclassification in the measurement of the risk factors. A prospective study might avoid many of these problems but the rarity of suicide means that such a study would have to be extremely large.

Descriptive data

Our finding that many in-patient suicides occur outside the hospital site confirms that in previous studies (Reference Fernando and StormFernando & Storm, 1984; Reference Morgan and PriestMorgan & Priest, 1991; Reference Proulx, Lesage and GrunbergProulx et al, 1997; Reference Sharma, Persad and KuenemanSharma et al, 1998). The fact that the most common method of suicide was drowning was probably because this method was easily available: for instance, 22 of 31 drownings took place in rivers adjacent to or near hospital sites. The high number of women committing suicide by drowning is striking.

Possible risk factors

The variable with the strongest association with suicide was suicidal thoughts or acts - there was a ‘dose-response’ between the apparent strength of suicidal thoughts, as measured by the extent to which the patient had acted on the ideation, and the risk of suicide. A recent descriptive UK study has also identified suicidal ideation as of paramount importance in the assessment of risk (Reference Morgan and StantonMorgan & Stanton, 1997). Our findings extend those of previous work and confirm the importance of suicidal thoughts or activity as the most important risk factor for suicide in psychiatric in-patients.

One of the most striking findings of the study is that some of the factors associated with suicide in the general population (being male, single, living alone, being unemployed, substance abuse) (Reference Charlton, Kelly and DunnellCharlton et al, 1993), were not associated with suicides by hospital in-patients. This finding, which is clearly important in risk assessment, is consistent with previous case-control studies investigating risk factors for suicide following discharge from psychiatric hospital (Reference Dennehy, Appleby and ThomasDennehy et al, 1996; Reference Appleby, Dennehy and ThomasAppleby et al, 1999b ). The explanation may be that these factors are strongly associated with both admission to psychiatric hospitals and suicidal ideation.

Substance abuse was associated with a reduced risk of suicide: it may be that patients admitted for these problems are not as acutely mentally ill (often being admitted for detoxification) as some other patients and do not have the same suicide risk.

Comparison with similar studies

Although there have been several descriptive studies of in-patient suicide in the UK (Reference Copas and RobinCopas & Robin, 1982; Reference Langley and BayattiLangley & Bayatti, 1984; Reference Morgan and PriestMorgan & Priest, 1991), there have been no UK case-control studies. We are aware of four case-control studies of psychiatric hospital suicides worldwide that included only in-patients (Reference Modestin, Zarro and WaldvogelModestin et al, 1992; Reference Read, Thomas and MellsopRead et al, 1993; Reference Roy and DraperRoy & Draper, 1995; Reference Sharma, Persad and KuenemanSharma et al, 1998). These had fewer cases than our study and applied univariate analysis only. One was restricted to patients with schizophrenia (Reference Modestin, Zarro and WaldvogelModestin et al, 1992). In two others the diagnosis of schizophrenia was found to be a risk factor, while in the fourth the most common diagnosis was a mood disorder (Reference Read, Thomas and MellsopRead et al, 1993; Reference Roy and DraperRoy & Draper, 1995; Reference Sharma, Persad and KuenemanSharma et al, 1998). It has been shown that previous self-harm, in particular during the index admission, is one of the most potent risk factors (Reference Modestin, Zarro and WaldvogelModestin et al, 1992; Reference Read, Thomas and MellsopRead et al, 1993; Reference Roy and DraperRoy & Draper, 1995; Reference Sharma, Persad and KuenemanSharma et al, 1998). Compulsory admission was not identified as a risk factor in our study, but has been in others (Reference Roy and DraperRoy & Draper, 1995; Reference Sharma, Persad and KuenemanSharma et al, 1998). This may be due to differences in the content and application of mental health legislation. Our study suggests that a history of suicide in a first-degree relative is a possible risk factor for in-patient suicide. There was no significant difference between cases and controls regarding history of psychiatric illness in a first-degree relative. One other case-control study which investigated family history found that in-patient suicide cases were more likely to have a family history of psychiatric problems, but were not significantly different regarding a family history of suicide (Reference Sharma, Persad and KuenemanSharma et al, 1998). It is not clear whether that study restricted the definition of ‘family history’ to first-degree relatives.

An association between chronic mental illness and in-patient suicide was shown in one study (Reference Modestin, Zarro and WaldvogelModestin et al, 1992), but not in the other studies that looked at this possibility (Reference Read, Thomas and MellsopRead et al, 1993; Reference Sharma, Persad and KuenemanSharma et al, 1998). Other studies have not identified a relationship between abuse of alcohol or illicit drugs and the risk of in-patient suicide (Reference Read, Thomas and MellsopRead et al, 1993; Reference Roy and DraperRoy & Draper, 1995).

Prediction and prevention of suicide by in-patients

The reason for identifying factors associated with suicide by in-patients is that such knowledge may be useful in helping to identify individuals at risk and to prevent suicides occurring. Previous studies have attempted to develop models to predict which psychiatric patients might commit suicide (Reference PokornyPokorny, 1983; Reference Goldstein, Black and NasrallahGoldstein et al, 1991), but have been unable to generate models with sufficiently high sensitivity and specificity to be any good at predicting such a rare event. In the present study, we have attempted to identify possible risk factors for suicide in patients in psychiatric hospitals - a particularly high-risk group.

Our model suggested that 30-40% of in-patients with all five risk factors would commit suicide, as would 5% of those with three or four risk factors. Expressed at the level of the individual patient, a 5% risk means that, for the individual, there is a 1 in 20 risk of suicide while in in-patient care. However, the clinical usefulness of these findings is limited because such combinations of risk factors are extremely rare. Among the 97 suicides included in our data set, only one had all five risk factors and only one other had a predicted risk of suicide of > 5%. Reducing the threshold of concern to a 1% risk of suicide would have identified over 25% of those who committed suicide. The majority of those who committed suicide had predicted risks of suicide below 1%, 14% had no risk factors and 30% had only one risk factor. The model would therefore not have been able to predict the majority of the actual suicides without having an unacceptable (>99%) false positive rate. On the other hand, using the presence of three, four or five predictive factors as rough clinical guides (see Results) may correctly identify a small number of patients as being at high risk. However, the reliability of the predictive model we have developed is uncertain, because it has not been validated in a second independent data set. It should be feasible to test the model in independent data sets derived from other large-scale record linkage studies.

The suicide of a psychiatric hospital in-patient is a rare but important event. As well as the grief caused to family and friends, and the significant effects it can have on other patients, it also raises questions of responsibility and guilt for the professionals involved in caring for the patient. This study suggests that, unless a very high number of false positives is considered acceptable, it is unavoidable that clinicians will fail to identify before-hand a high proportion of suicides, even in a high-risk group such as psychiatric hospital in-patients.

Clinical Implications and Limitations

CLINICAL IMPLICATIONS

  • We found that suicide by psychiatric hospital in-patients was strongly associated with suicidal ideas or acts of self-harm preceding or during admission.

  • Five predictors had adjusted likelihood ratios greater than 2: recent bereavement, presence of delusions, suicidal ideation, chronic mental illness and family history of suicide. A patient with any three or more (or delusions plus chronic mental illness plus two others) of the five predictors would have a risk of suicide of over 5%.

  • Only 2% of those patients with a 1 in 20 risk of suicide or higher were correctly identified by the predictors.

LIMITATIONS

  • The clinical and socio-demographic information on cases and controls was largely determined from retrospective examination of case notes, and the completeness of such information may vary. Also, the recording of information from case notes was not carried out blind to case-control status.

  • All suicide cases were confirmed as such by examination of clinical records and death certificates, but some cases could have been missed if the coroner's verdict was other than suicide or open.

  • The predictive model has not been validated in an independent data set.

ACKNOWLEDGEMENTS

Supported in part by grants from Oxford and Anglia Regional Health Authority and Oxfordshire Health Authority. J.P. was funded by the Wellcome Trust as a research registrar in psychiatry on the Oxford rotational training scheme. K.H. is supported by Oxfordshire Mental Healthcare NHS Trust and South East Regional NHSE Research and Development Committee.

We thank Ed Juszczak and Doug Altman for statistical advice during this project.

Footnotes

Declaration of interest

No conflict of interest. Financial support detailed in Acknowledgements.

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Figure 0

Table 1 Characteristics of people who committed suicide while in in-patient care

Figure 1

Table 2 Case-control comparisons of possible risk factors for in-patient suicide

Figure 2

Table 3 Likelihood ratios and post-test probabilities of the factors predictive of in-patient suicide

Figure 3

Table 4 Risk of suicide in the psychiatric in-patients on admission: characteristics of the final model of factors predictive of suicide.

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