Skip to main content
×
×
Home

Tardive dyskinesia in schizophrenia

  • Peter F. Liddle (a1)
Summary

Sarró et al report grey matter deficits associated with tardive dyskinesia in schizophrenia. Much evidence suggests that the intrinsic pathophysiology of schizophrenia contributes to predisposition to tardive dyskinesia. The possibility that antipsychotics might play a causal role in the grey matter deficits cannot be excluded, but the evidence is tenuous.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Tardive dyskinesia in schizophrenia
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Tardive dyskinesia in schizophrenia
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Tardive dyskinesia in schizophrenia
      Available formats
      ×
Copyright
References
Hide All
1 Sarró, S, Pomarol-Clotet, E, Canales-Rodríguez, EJ, Salvador, R, Gomar, JJ, Ortiz-Gil, J, et al. Structural brain changes associated with tardive dyskinesia in schizophrenia. Br J Psychiatry 2013; 203: 51–7.
2 Owens, DG, Johnstone, EC, Frith, CD. Spontaneous involuntary disorders of movement: their prevalence, severity, and distribution in chronic schizophrenics with and without treatment with neuroleptics. Arch Gen Psychiatry 1982; 39: 452–61.
3 Glazer, WM, Hafez, H. A comparison of masking effects of haloperidol versus molindone in tardive dyskinesia. Schizophr Res 1990; 3: 315–20.
4 Kegeles, LS, Abi-Dargham, A, Frankle, WG, Gil, R, Cooper, TB, Slifstein, M, et al. Increased synaptic dopamine function in associative regions of the striatum in schizophrenia. Arch Gen Psychiatry 2010; 67: 231–9.
5 Laruelle, M, Abi-Dargham, A, Gil, R, Kegeles, L, Innis, R. Increased dopamine transmission in schizophrenia: relationship to illness phases. Biol Psychiatry 1999; 46: 5672.
6 Palaniyappan, L, Balain, V, Radua, J, Liddle, PF. Structural correlates of auditory hallucinations in schizophrenia: a meta-analysis. Schizophr Res 2012; 46: 1249–56.
7 Palaniyappan, L, Liddle, PF. Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction. J Psychiatry Neurosci 2012; 37: 1727.
8 Hayashi-Takagi, A, Sawa, A. Disturbed synaptic connectivity in schizophrenia: convergence of genetic risk factors during neurodevelopment. Brain Res Bull 2010; 83: 140–6.
9 Liddle, PF, Barnes, TR, Speller, J, Kibel, D. Negative symptoms as a risk factor for tardive dyskinesia in schizophrenia. Br J Psychiatry 1993; 163: 776–80.
10 Morgenstern, H, Glazer, WM. Identifying risk factors for tardive dyskinesia among long-term outpatients maintained with neuroleptic medications. Results of the Yale tardive dyskinesia study. Arch Gen Psychiatry 1993; 50: 723–33.
11 Morgenstern, H, Glazer, WM, Niedzwiecki, D, Nourjah, P. The impact of neuroleptic medication on tardive dyskinesia: a meta-analysis of published studies. Am J Public Health 1987; 77: 717–24.
12 Ebdrup, BH, Nørbak, H, Borgwardt, S, Glenthøj, B. Volumetric changes in the basal ganglia after antipsychotic monotherapy: a systematic review. Curr Med Chem 2013; 20: 438–47.
13 Ho, BC, Andreasen, NC, Ziebell, S, Pierson, R, Magnotta, V. Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Arch Gen Psychiatry 2011; 68: 128–37.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 19 *
Loading metrics...

Abstract views

Total abstract views: 53 *
Loading metrics...

* Views captured on Cambridge Core between 3rd January 2018 - 26th April 2018. This data will be updated every 24 hours.

Tardive dyskinesia in schizophrenia

  • Peter F. Liddle (a1)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *