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Temporal course of auditory hallucinations

  • Sukhwinder S. Shergill (a1), Mick J. Brammer (a1), Edson Amaro (a1), Steve C. R. Williams (a1), Robin M. Murray (a1) and Phillip K. Mcguire (a1)...
Summary

We used functional magnetic resonance imaging to examine how brain activity associated with auditory verbal hallucinations in schizophrenia changed during hallucinatory events. Activation in the left inferior frontal and right middle temporal gyri was evident 6–9s before the person signalled the onset of the hallucination, whereas activation in the bilateral temporal gyri and the left insula coincided with the perception of the hallucination. This supports the hypothesis that during hallucinations activation in cortical regions mediating the generation of inner speech may precede the engagement of areas implicated in the perception of auditory verbal material.

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Copyright
Corresponding author
Dr Sukhwinder S. Shergill, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK. Tel: 020 7848 0350; fax: 020 7848 0350; e-mail: s.shergill@iop.kcl.ac.uk
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Declaration of interest

None. S.S.S. and E.A. were supported by the Wellcome Trust. S.S.S. received funding from the National Alliance for Research on Schizophrenia and Depression.

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References
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David, A. S. (1994) The neuropsychological origin of auditory hallucination. In The Neuropsychology of Schizophrenia (eds David, A. S. & Cutting, J. C.), pp. 269313. Mahwah, NJ: Erlbaum.
Dierks, T., Linden, D. E., Jandl, M., et al (1999) Activation of Heschl's gyrus during auditory hallucinations. Neuron, 22, 615621.
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Shergill, S. S., Brammer, M. J., Williams, S., et al (2000) Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging. Archives of General Psychiatry, 57, 10331038.
Shergill, S. S., Bullmore, E. T., Brammer, M. J., et al (2001) A functional MRI study of auditory verba imagery. Psychological Medicine, 31, 241253.
Shergill, S. S., Brammer, M., Fukuda, R., et al (2002) Modulation of activity in temporal cortex during generation of inner speech. Human Brain Mapping, 16, 219227.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Temporal course of auditory hallucinations

  • Sukhwinder S. Shergill (a1), Mick J. Brammer (a1), Edson Amaro (a1), Steve C. R. Williams (a1), Robin M. Murray (a1) and Phillip K. Mcguire (a1)...
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eLetters

Left frontal activation: the voice or the finger?

Michael D Hunter, Wellcome Clinical Fellow
09 January 2005

We read Shergill and colleagues’ (2004) paper about the temporal course of brain activity associated with auditory verbal hallucinations (AVH) with considerable interest. In that study, the researchers used functional magnetic resonance imaging to reveal those brain regions activated before, during and after AVH (the occurrence of which was indicated by patients pressing a button). They concluded that activation of the left inferior frontal gyrus some 9s prior to button pressing supports the theory that hallucinations originate in brain areas involved in the generation of ‘inner speech’. Given the importance of this questionfor future paradigm development, we wish to offer constructive comment.

There is a difficulty associated with the experimental method as described. Because no control condition was included (in which, for example, subjects might self-initiate button presses, unrelated to the timing of AVH) we cannot ascertain whether the frontal activation reportedby Shergill and colleagues (2004) was attributable to the presence of AVH or the procedure of button pressing itself; a problem which emerged in theinterpretation of an earlier, similar study (McGuire et al, 1993; Krams etal, 1996). In healthy subjects, we have observed that the left frontal cortex also activates 9s prior to simple, self-initiated button pressing (Hunter et al, 2004). Obviously, in healthy subjects this observed effect has no relationship to AVH (it is a feature of the temporal evolution of normal voluntary motor behaviour). During such behaviour, maximal frontal activity is seen in the middle and inferior frontal gyri (9s prior to button pressing). The temporal sequence of frontal activation observed by Shergill and colleagues (2004) could be related to the occurrence of hallucinations or it could be attributable to the self-initiation of motoraction (button pressing). This methodological consideration radically constrains the authors’ conclusions.The techniques of functional neuroimaging are complex and unfamiliar to most general readers. We hope that the concern we raise is helpful in elucidating the methodological issues inherent in studies such as those byShergill and colleagues (2004).

Hunter, M.D., Green, R.D.J., Wilkinson, I.D., et al (2004) Spatial and temporal dissociation in prefrontal cortex during action execution. NeuroImage, 23, 1186-1191.

Krams, M., Deiber, M-P., Frackowiak, R.S.J., et al (1996) Broca’s area and mental preparation. NeuroImage, 3, S392.

McGuire, P.K., Shah, G.M.S. & Murray, R.M. (1993) Increased bloodflow in Broca’s area during auditory hallucinations in schizophrenia. Lancet, 342, 703-706.

Shergill, S.S., Brammer, M.J., Amaro, E., et al (2004) Temporal course of auditory hallucinations. British Journal of Psychiatry, 185, 516-517.

M.D. Hunter, S.A. Spence Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK. E-mail: m.d.hunter@sheffield.ac.uk
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Conflict of interest: None Declared

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