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Towards a Neuropsychology of Schizophrenia

  • Christopher D. Frith (a1) and D. John Done (a1)
Abstract

A viable neuropsychology of schizophrenia requires, first, that signs and symptoms be understood in terms of underlying psychological processes and, second, that these underlying processes be related to brain systems. We propose that the negative signs of schizophrenia reflect a defect in the initiation of spontaneous action, while the positive symptoms reflect a defect in the internal monitoring of action. The spontaneous initiation of action depends upon brain systems linking the prefrontal cortex and the basal ganglia. Internal monitoring, carried out in the hippocampus, of spontaneous action, depends upon links between the prefrontal cortex and the hippocampus via the parahippocampal cortex and the cingulate cortex.

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Footnotes
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Extended version of a lecture given at a Royal College of Psychiatrists' meeting in January 1987, as part of the Maudsley Bequest series.

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References
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
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Towards a Neuropsychology of Schizophrenia

  • Christopher D. Frith (a1) and D. John Done (a1)
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