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Transcranial direct current stimulation for acute major depressive episodes: Meta-analysis of individual patient data

  • André R. Brunoni (a1), Adriano H. Moffa (a1), Felipe Fregni (a2), Ulrich Palm (a3), Frank Padberg (a3), Daniel M. Blumberger (a4), Zafiris J. Daskalakis (a4), Djamila Bennabi (a5), Emmanuel Haffen (a5), Angelo Alonzo (a6) and Colleen K. Loo (a6)...
Abstract
Background

Transcranial direct current stimulation (tDCS) is a non-pharmacological intervention for depression. It has mixed results, possibly caused by study heterogeneity.

Aims

To assess tDCS efficacy and to explore individual response predictors.

Method

Systematic review and individual patient data meta-analysis.

Results

Data were gathered from six randomised sham-controlled trials, enrolling 289 patients. Active tDCS was significantly superior to sham for response (34% v. 19% respectively, odds ratio (OR) = 2.44, 95% CI 1.38–4.32, number needed to treat (NNT) = 7), remission (23.1% v. 12.7% respectively, OR = 2.38, 95% CI 1.22–4.64, NNT = 9) and depression improvement (B coefficient 0.35, 95% CI 0.12–0.57). Mixed-effects models showed that, after adjustment for other predictors and confounders, treatment-resistant depression and higher tDCS ‘doses' were, respectively, negatively and positively associated with tDCS efficacy.

Conclusions

The effect size of tDCS treatment was comparable with those reported for repetitive transcranial magnetic stimulation and antidepressant drug treatment in primary care. The most important parameters for optimisation in future trials are depression refractoriness and tDCS dose.

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Copyright
Corresponding author
André R. Brunoni, MD, PhD, Interdisciplinary Center for Applied Neuromodulation, Av. Professor Lineu Prestes, 2565, 3o andar, CEP 05508-000, São Paulo (SP), Brazil. Email: brunoni@usp.br
Footnotes
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Declaration of interest

Z.J.D. has served on the advisory board for Sunovion, Hoffmann-La Roche Limited and Merck, and received speaker support from Eli Lilly.

Footnotes
References
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Transcranial direct current stimulation for acute major depressive episodes: Meta-analysis of individual patient data

  • André R. Brunoni (a1), Adriano H. Moffa (a1), Felipe Fregni (a2), Ulrich Palm (a3), Frank Padberg (a3), Daniel M. Blumberger (a4), Zafiris J. Daskalakis (a4), Djamila Bennabi (a5), Emmanuel Haffen (a5), Angelo Alonzo (a6) and Colleen K. Loo (a6)...
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