1Bhattacharya, A, Derecki, NC, Lovenberg, TW, Drevets, WC. Role of neuro-immunological factors in the pathophysiology of mood disorders. Psychopharmacology (Berl) 2016; 233(9): 1623–36.
2Dantzer, R, O'Connor, JC, Freund, GG, Johnson, RW, Kelley, KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008; 9(1): 46–56.
3Strawbridge, R, Arnone, D, Danese, A, Papadopoulos, A, Herane Vives, A, Cleare, AJ. Inflammation and clinical response to treatment in depression: a meta-analysis. Eur Neuropsychopharmacol 2015; 25(10): 1532–43.
4Maes, M, Meltzer, HY, Bosmans, E, Bergmans, R, Vandoolaeghe, E, Ranjan, R, et al. Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression. J Affect Disord 1995; 34(4): 301–9.
5Raison, CL, Capuron, L, Miller, AH. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006; 27(1): 24–31.
6Frasure-Smith, N, Lesperance, F, Irwin, MR, Sauve, C, Lesperance, J, Theroux, P. Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromes. Biol Psychiatry 2007; 62(4): 302–8.
7Kinney, DK, Tanaka, M. An evolutionary hypothesis of depression and its symptoms, adaptive value, and risk factors. J Nerv Ment Dis 2009; 197(8): 561–7.
8Haapakoski, R, Mathieu, J, Ebmeier, KP, Alenius, H, Kivimaki, M. Cumulative meta-analysis of interleukins 6 and 1beta, tumour necrosis factor alpha and C-reactive protein in patients with major depressive disorder. Brain Behav Immun 2015; 49: 206–15.
9Young, JJ, Silber, T, Bruno, D, Galatzer-Levy, IR, Pomara, N, Marmar, CR. Is there progress? An overview of selecting biomarker candidates for major depressive disorder. Front Psychiatry 2016; 7: 72.
10Domenici, E, Wille, DR, Tozzi, F, Prokopenko, I, Miller, S, McKeown, A, et al. Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections. PLoS One 2010; 5(2): e9166.
11Glaser, R, Robles, TF, Sheridan, J, Malarkey, WB, Kiecolt-Glaser, JK. Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adults. Arch Gen Psychiatry 2003; 60(10): 1009–14.
12Cattaneo, A, Gennarelli, M, Uher, R, Breen, G, Farmer, A, Aitchison, KJ, et al. Candidate genes expression profile associated with antidepressants response in the GENDEP study: differentiating between baseline ‘predictors’ and longitudinal ‘targets’. Neuropsychopharmacology 2013; 38(3): 377–85.
13Cattaneo, A, Ferrari, C, Uher, R, Bocchio-Chiavetto, L, Riva, MA, Consortium, MRCI, et al. Absolute measurements of macrophage migration inhibitory factor and interleukin-1-beta mRNA levels accurately predict treatment response in depressed patients. Int J Neuropsychopharmacol 2016; 19(10): pyw045.
14Janssen, DG, Caniato, RN, Verster, JC, Baune, BT. A psychoneuroimmunological review on cytokines involved in antidepressant treatment response. Hum Psychopharmacol 2010; 25(3): 201–15.
15Leday, GGR, Vertes, PE, Richardson, S, Greene, JR, Regan, T, Khan, S, et al. Replicable and coupled changes in innate and adaptive immune gene expression in two case-control studies of blood microarrays in major depressive disorder. Biol Psychiatry 2018; 83(1):79–80.
16Hickman, RJ, Khambaty, T, Stewart, JC. C-reactive protein is elevated in atypical but not nonatypical depression: data from the National Health and Nutrition Examination survey (NHANES) 1999-2004. J Behav Med 2014; 37(4): 621–9.
17Miller, GE, Cole, SW. Clustering of depression and inflammation in adolescents previously exposed to childhood adversity. Biol Psychiatry 2012; 72(1): 34–40.
18Copeland, WE, Shanahan, L, Worthman, C, Angold, A, Costello, EJ. Cumulative depression episodes predict later C-reactive protein levels: a prospective analysis. Biol Psychiatry 2012; 71(1): 15–21.
19Liukkonen, T, Rasanen, P, Jokelainen, J, Leinonen, M, Jarvelin, MR, Meyer-Rochow, VB, et al. The association between anxiety and C-reactive protein (CRP) levels: results from the Northern Finland 1966 birth cohort study. Eur Psychiatry 2011; 26(6): 363–9.
20Abdi, H, Williams, LJ. Partial least squares methods: partial least squares correlation and partial least square regression. Methods Mol Biol 2013; 930: 549–79.
21Wold, H. Estimation of Principal Components and Related Models by Iterative Least Squares. Academic Press, 1966.
22Wold, S. Personal memories of the early PLS development. Chemometrcs Intell Lab Syst 2001; 58: 83–4.
23Menzies, L, Achard, S, Chamberlain, SR, Fineberg, N, Chen, CH, del Campo, N, et al. Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain 2007; 130(Pt 12): 3223–36.
24American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th ed). American Psychiatric Publishing, 2013.
25Spitzer, MB, Miriam, G, Williams, JB. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID). American Psychiatric Press, Inc., 1996.
26Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56–62.
27Desseilles, M, Witte, J, Chang, TE, Iovieno, N, Dording, CM, Ashih, H, et al. Assessing the adequacy of past antidepressant trials: a clinician's guide to the antidepressant treatment response questionnaire. J Clin Psychiatry 2011; 72(8): 1152–4.
28Marcus, RN, McQuade, RD, Carson, WH, Hennicken, D, Fava, M, Simon, JS, et al. The efficacy and safety of aripiprazole as adjunctive therapy in major depressive disorder: a second multicenter, randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol 2008; 28(2): 156–65.
29Katona, CL, Robertson, MM, Abou-Saleh, MT, Nairac, BL, Edwards, DR, Lock, T, et al. Placebo-controlled trial of lithium augmentation of fluoxetine and lofepramine. Int Clin Psychopharmacol 1993; 8(4): 323.
30Beck, AT, Steer, RA, Brown, GK. Manual for Beck Depression Inventory - II. Psychological Corporation, 1996.
31Spielberger, CD, Gorsuch, RL, Lushene, R, Vagg, PR, Jacobs, GA. Manual for the State-Trait Anxiety Inventory. Consulting Psychologists Press, 1983.
32Chalder, T, Berelowitz, G, Pawlikowska, T, Watts, L, Wessely, S, Wright, D, et al. Development of a fatigue scale. J Psychosom Res 1993; 37(2): 147–53.
33Snaith, RP, Hamilton, M, Morley, S, Humayan, A, Hargreaves, D, Trigwell, P. A scale for the assessment of hedonic tone the Snaith-Hamilton Pleasure Scale. Br J Psychiatry 1995; 167(1): 99–103.
34Bernstein, DP, Fink, L, Handelsman, L, Foote, J, Lovejoy, M, Wenzel, K, et al. Initial reliability and validity of a new retrospective measure of child abuse and neglect. Am J Psychiatry 1994; 151(8): 1132–6.
35Bassuk, SS, Rifai, N, Ridker, PM. High-sensitivity C-reactive protein: clinical importance. Curr Probl Cardiol 2004; 29(8): 439–93.
36Raison, CL, Rutherford, RE, Woolwine, BJ, Shuo, C, Schettler, P, Drake, DF, et al. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 2013; 70(1): 31–41.
37JMP Pro ® Version 13.0, Cary, North Carolina, USA. SAS Institute Inc., 2017.
38Garthwaite, PH. An interpretation of partial least squares. J Am Stat Assoc 1994; 89(425): 122–7.
39Höskuldsson, A. PLS regression methods. J Chemometrics 1988; 2(3): 211–28.
40Cox, I, Gaudard, M. Discovering Partial Least Squares with JMP. SAS Institute Inc., 2013.
41Terpening, WD. Statistical Analysis for Business Using JMP: A Student's Guide. SAS Institute Inc., 2011.
42Ridker, PM, Buring, JE, Cook, NR, Rifai, N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation 2003; 107(3): 391–7.
43Zhao, Y, Lv, G. Correlation of C-reactive protein level and obesity in Chinese adults and children: a meta-analysis. J Endocrinol Invest 2013; 36(8): 642–7.
44Janka, Z. Serotonin dysfunctions in the background of the seven deadly sins. Ideggyogy Sz 2003; 56(11–12): 376–85.
45Al-Harbi, KS. Treatment-resistant depression: therapeutic trends, challenges, and future directions. Patient Prefer Adherence 2012; 6: 369–88.
46Schosser, A, Serretti, A, Souery, D, Mendlewicz, J, Zohar, J, Montgomery, S, et al. European Group for the Study of Resistant Depression (GSRD) – where have we gone so far: review of clinical and genetic findings. Eur Neuropsychopharmacol 2012; 22(7): 453–68.
47Lepine, JP, Briley, M. The increasing burden of depression. Neuropsychiatr Dis Treat 2011; 7(suppl 1): 3–7.
48Bhattacharya, A, Drevets, WC. Role of neuro-immunological factors in the pathophysiology of mood disorders: implications for novel therapeutics for treatment resistant depression. Curr Top Behav Neurosci 2017; 31: 339–56.
49Carvalho, LA, Torre, JP, Papadopoulos, AS, Poon, L, Juruena, MF, Markopoulou, K, et al. Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system. J Affect Disord 2013; 148(1): 136–40.
50Jha, MK, Minhajuddin, A, Gadad, BS, Greer, T, Grannemann, B, Soyombo, A, et al. Can C-reactive protein inform antidepressant medication selection in depressed outpatients? Findings from the CO-MED trial. Psychoneuroendocrinology 2017; 78: 105–13.
51Uher, R, Tansey, KE, Dew, T, Maier, W, Mors, O, Hauser, J, et al. An inflammatory biomarker as a differential predictor of outcome of depression treatment with escitalopram and nortriptyline. Am J Psychiatry 2014; 171(12): 1278–86.
52Walker, AJ, Foley, BM, Sutor, SL, McGillivray, JA, Frye, MA, Tye, SJ. Peripheral proinflammatory markers associated with ketamine response in a preclinical model of antidepressant-resistance. Behav Brain Res 2015; 293: 198–202.
53Wichers, MC, Koek, GH, Robaeys, G, Verkerk, R, Scharpe, S, Maes, M. IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity. Mol Psychiatry 2005; 10(6): 538–44.
54Mechawar, N, Savitz, J. Neuropathology of mood disorders: do we see the stigmata of inflammation? Transl Psychiatry 2016; 6(11): e946.
55Postal, M, Appenzeller, S. The importance of cytokines and autoantibodies in depression. Autoimmun Rev 2015; 14(1): 30–5.
56Haroon, E, Raison, CL, Miller, AH. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 2012; 37(1): 137–62.
57Berg, AH, Scherer, PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res 2005; 96(9): 939–49.
58Capuron, L, Su, S, Miller, AH, Bremner, JD, Goldberg, J, Vogt, GJ, et al. Depressive symptoms and metabolic syndrome: is inflammation the underlying link? Biol Psychiatry 2008; 64(10): 896–900.
59Mohamed-Ali, V, Goodrick, S, Rawesh, A, Katz, DR, Miles, JM, Yudkin, JS, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 1997; 82(12): 4196–200.
60Duivis, HE, Vogelzangs, N, Kupper, N, de Jonge, P, Penninx, BW. Differential association of somatic and cognitive symptoms of depression and anxiety with inflammation: findings from the Netherlands Study of Depression and Anxiety (NESDA). Psychoneuroendocrinology 2013; 38(9): 1573–85.
61Capuron, L, Gumnick, JF, Musselman, DL, Lawson, DH, Reemsnyder, A, Nemeroff, CB, et al. Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology 2002; 26(5): 643–52.
62Reichenberg, A, Yirmiya, R, Schuld, A, Kraus, T, Haack, M, Morag, A, et al. Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 2001; 58(5): 445–52.
63Sachs-Ericsson, N, Kendall-Tackett, K, Hernandez, A. Childhood abuse, chronic pain, and depression in the National Comorbidity Survey. Child Abuse Negl 2007; 31(5): 531–47.
64Baumeister, D, Akhtar, R, Ciufolini, S, Pariante, CM, Mondelli, V. Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-alpha. Mol Psychiatry 2016; 21(5): 642–9.
65Lu, S, Peng, H, Wang, L, Vasish, S, Zhang, Y, Gao, W, et al. Elevated specific peripheral cytokines found in major depressive disorder patients with childhood trauma exposure: a cytokine antibody array analysis. Compr Psychiatry 2013; 54(7): 953–61.