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Unsound Methodology in Investigating a Pseudoautosomal Locus in Schizophrenia

  • David Curtis (a1) and Hugh Gurling (a1)
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We have reservations about accepting the conclusions made by Crow et al (1989), namely that there is evidence that susceptibility to schizophrenia may be transmitted by a pseudoautosomal locus. In our view the methodology of the study is unsound. Additionally the data presented by the authors, when analysed correctly, do not support their hypothesis.

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Crow, T. J., DeLisi, L. E. & Johnstone, E. C. (1989) Concordance by sex in sibling pairs with schizophrenia is paternally inherited –Evidence for a pseudoautosomal locus. British Journal of Psychiatry, 155, 9297.
Sturt, E. & Shur, E. (1985) Sex concordance for schizophrenia in proband-relative pairs. British Journal of Psychiatry, 147, 4447.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Unsound Methodology in Investigating a Pseudoautosomal Locus in Schizophrenia

  • David Curtis (a1) and Hugh Gurling (a1)
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