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Use of sertraline, paroxetine and fluvoxamine by nursing women

  • Victoria Hendrick (a1), Alan Fukuchi (a2), Lori Altshuler (a3), Mel Widawski (a3), Amy Wertheimer (a4) and Martina V. Brunhuber (a4)...
Abstract
Background

The pharmacological treatment of depression in nursing women requires information on the magnitude of medication exposure to the infant that may occur through breast milk.

Aims

To examine serum concentrations of antidepressants in infants exposed to these medications through breast-feeding.

Method

Maternal and infant serum concentrations of sertraline, paroxetine and fluvoxamine were determined with high-performance liquid chromatography (limit of detections=1 ng/ml).

Results

No detectable medication was present in any infant exposed to paroxetine (n=16) or fluvoxamine (n=4). Among infants exposed to sertraline (n=30), detectable medication was present in 24% of serum samples. A significant negative correlation was found between infant age and infant serum concentration. Sertraline was significantly more likely to be detected in an infant if the mother's daily dose was 100 mg or higher. No adverse sequelae occurred in any infant.

Conclusions

This study shows that paroxetine, fluvoxamine and sertraline produce minimal exposure to infants when taken by nursing mothers.

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Copyright
Corresponding author
Dr Victoria Hendrick, Department of Psychiatry, UCLA, 300 Medical Plaza, Suite 2345, Los Angeles, CA 90095, USA
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Declaration of interest

This study was supported by the National Institute of Mental Health, Smith Kline Beecham and Pfizer.

Footnotes
References
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Use of sertraline, paroxetine and fluvoxamine by nursing women

  • Victoria Hendrick (a1), Alan Fukuchi (a2), Lori Altshuler (a3), Mel Widawski (a3), Amy Wertheimer (a4) and Martina V. Brunhuber (a4)...
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