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Vagus nerve stimulation in chronic treatment-resistant depression: Preliminary findings of an open-label study

  • Ciaran D. Corcoran (a1), Philip Thomas (a2), Jack Phillips (a2) and Veronica O'Keane (a3)

Summary

We evaluated the efficacy and safety of vagus nerve stimulation therapy in the treatment of 11 patients with chronic treatment-resistant depression. Mood was evaluated at frequent intervals over the year following implantation. All measures of depression, including the Hamilton Rating Scale for Depression reduced significantly. The response and remission rates were 55% and 27% respectively at 1 year. Side-effects were common, and some were severe.

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Copyright

Corresponding author

Dr Ciaran Corcoran, Mental Health Unit, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK. Email: ciaran.corcoran@ncl.ac.uk

Footnotes

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Declaration of interest

Cyberonics Incorporated, makers of the Neuro Cybernetic Prosthesis system, sponsored this study.

Footnotes

References

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Bridges, P. K., Bartlett, J. R., Hale, A. S., et al (1994) Psychosurgery: stereotactic subcaudate tractomy. An indispensable treatment. British Journal of Psychiatry, 165, 599611.
First, M. B., Spitzer, R. L., Gibbon, M., et al (1996) Structured Clinical Interview for DSM–IV Axis I Disorders, Clinician Version (SCID–CV). Washington, DC: American Psychiatric Press.
Folkerts, H. W., Michael, N., Tolle, R., et al (1997) Electroconvulsive therapy v. paroxetine in treatment-resistant depression – a randomized study. Acta Psychiatrica Scandinavica, 96, 334342.
George, M. S., Sackeim, H. A., Rush, A. J., et al (2000) Vagus nerve stimulation: a new tool for brain research and therapy. Biological Psychiatry, 47, 287295.
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 5662.
Marangell, L. B., Rush, A. J., George, M. S., et al (2002) Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes. Biological Psychiatry, 51, 280287.
Mayberg, H. S., Lozano, A. M., Voon, V., et al (2005) Deep brain stimulation for treatment-resistant depression. Neuron, 45, 651660.
Royal College of Psychiatrists (2002) Neurosurgery for Mental Disorder. Council Report CR89. London: Royal College of Psychiatrists.
Rush, A. J., Gilles, D. E., Schlesser, M. A., et al (1986) The Inventory for Depressive Symptomatology (IDS): preliminary findings. Psychiatry Research, 18, 6587.
Scott, J. (2000) Treatment of chronic depression. New England Journal of Medicine, 20, 15181520.
Stewart, J. W., McGrath, P. J., Quitkin, F. M., et al (1993) Chronic depression response to placebo, imipramine and phenelzine. Journal of Clinical Psychopharmacology, 13, 391396.
UK ECT Review Group (2003) Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet, 361, 799808.
Ustun, T. B., Ayuso-Mateos, J. L., Chatterji, S., et al (2004) Global burden of depressive disorders in the year 2000. British Journal of Psychiatry, 184, 386392.

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Vagus nerve stimulation in chronic treatment-resistant depression: Preliminary findings of an open-label study

  • Ciaran D. Corcoran (a1), Philip Thomas (a2), Jack Phillips (a2) and Veronica O'Keane (a3)

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