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Vascular risk factors and incident late-life depression in a Korean population

  • Jae-Min Kim (a1), Robert Stewart (a2), Sung-Wan Kim (a3), Su-Jin Yang (a3), Il-Seon Shin (a3) and Jin-Sang Yoon (a3)...
Abstract
Background

Causal relationships between vascular factors and late-life depression are controversial.

Aims

To investigate prospective associations between risk factors for vascular disease and incidence of late-life depression.

Method

Of 661 community participants aged 65 years or over, without depression at baseline, 521 (79%) were re-evaluated 2 years later. At baseline and follow-up, a diagnostic interview for depression was carried out and information on vascular status, disability and cognitive function was gathered.

Results

Pre-existing heart disease, incident stroke and lower baseline high-density lipoprotein cholesterol level were significantly associated with incidence of late-life depression, independently of disability and cognitive function.

Conclusions

These results provide some support for a vascular aetiology of late-life depression. However, important risk factors for cerebrovascular disease such as hypertension and diabetes were not implicated, and the associations with lipid levels might still be explained by affective states earlier in life.

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Copyright
Corresponding author
Professor Jin-Sang Yoon, Department of Psychiatry, Chonnam National University Medical School, 5 Hak-Dong, Dong-gu, Kwangju 501-757, Republic of Korea. Tel. +82 62 220 6142; fax: +82 62 225 2351; email: jsyoon@chonnam.ac.kr
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Declaration of interest

None.

Funding detailed in Acknowledgements.

Footnotes
References
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  • ISSN: 0007-1250
  • EISSN: 1472-1465
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Vascular risk factors and incident late-life depression in a Korean population

  • Jae-Min Kim (a1), Robert Stewart (a2), Sung-Wan Kim (a3), Su-Jin Yang (a3), Il-Seon Shin (a3) and Jin-Sang Yoon (a3)...
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