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Vitamin D deficiency and depression in adults: systematic review and meta-analysis

  • Rebecca E. S. Anglin (a1), Zainab Samaan (a2), Stephen D. Walter (a3) and Sarah D. McDonald (a4)



There is conflicting evidence about the relationship between vitamin D deficiency and depression, and a systematic assessment of the literature has not been available.


To determine the relationship, if any, between vitamin D deficiency and depression.


A systematic review and meta-analysis of observational studies and randomised controlled trials was conducted.


One case-control study, ten cross-sectional studies and three cohort studies with a total of 31 424 participants were analysed. Lower vitamin D levels were found in people with depression compared with controls (SMD = 0.60,95% Cl 0.23–0.97) and there was an increased odds ratio of depression for the lowest v. highest vitamin D categories in the cross-sectional studies (OR = 1.31, 95% CI 1.0–1.71). The cohort studies showed a significantly increased hazard ratio of depression for the lowest v. highest vitamin D categories (HR=2.21, 95% CI 1.40–3.49).


Our analyses are consistent with the hypothesis that low vitamin D concentration is associated with depression, and highlight the need for randomised controlled trials of vitamin D for the prevention and treatment of depression to determine whether this association is causal.

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Corresponding author

Dr Rebecca Anglin, Department of Psychiatry and Behavioural Neurosciences, F413-1 Fontbonne Building, St Joseph's Hospital, 50 Charlton Avenue E, Hamilton, Ontario L8N 2A6, Canada. Email:


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Vitamin D deficiency and depression in adults: systematic review and meta-analysis

  • Rebecca E. S. Anglin (a1), Zainab Samaan (a2), Stephen D. Walter (a3) and Sarah D. McDonald (a4)


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Vitamin D deficiency and depression in adults: systematic review and meta-analysis

  • Rebecca E. S. Anglin (a1), Zainab Samaan (a2), Stephen D. Walter (a3) and Sarah D. McDonald (a4)
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