Skip to main content Accessibility help
×
×
Home

Biocompatibility of oxygen-plasma-treated polystyrene substrates

  • A. Vesel (a1), M. Mozetic (a1), M. Jaganjac (a2), L. Milkovic (a2), A. Cipak (a2) and N. Zarkovic (a2)...
Abstract

The biocompatibility of polystyrene (PS) samples has been improved by treatment with weakly ionized highly non-equilibrium oxygen plasma. Samples were exposed to plasma for 30 s for which they have received a dose of ions of 4.5 × 1017 m−2 and a neutral oxygen atom dose of 3 × 10−23 m−2. Both untreated and plasma-treated samples were tested for biocompatibility according to the same procedure. Proliferation of human mammary epithelial cells (HMECs) on samples revealed a dramatically improved biocompatibility of polystyrene treated by oxygen plasma. The HMECs were deposited on all samples and incubated for 1, 2 and 6 days. MTT test revealed about two times higher activity of cell enzymes after 48 h incubation. The activity for plasma-treated samples remained much higher than for untreated samples even after 6 days of incubation when the samples were already covered with a dense film of HMECs.

Copyright
Corresponding author
ae-mail: alenka.vesel@ijs.si
References
Hide All
[1]Kasemo, B., Surf. Sci. 500, 656 (2002)
[2]Klee, D., Höcker, H., Adv. Polym. Sci. 149, 1 (2000)
[3]Anselme, K., Biomaterials 21, 667 (2000)
[4]Pu, F.R., Williams, R.L., Markkula, T.K., Hunt, J.A., Biomaterials 23, 4705 (2002)
[5]Alves, C.M., Yang, Y., Carnes, D.L., Ong, J.L., Sylvia, V.L., Dean, D.D., Agrawal, C.M., Reis, R.L., Biomaterials 28, 307 (2007)
[6]Dowling, D.P., Miller, I.S., Ardhaoui, M., Gallagher, W.M., J. Biomater. Appl. 21, 1 (2010)
[7]Desmet, T., Morent, R., De Geyter, N., Leys, C., Schacht, E., Dubruel, P., Biomacromolecules 10, 2351 (2009)
[8]Geckeler, K.E., Wacker, R., Martini, F., Hack, A., Aicher, W.K., Cell. Physiol. Biochem. 13, 155 (2003)
[9]Poncin-Epaillard, F., Debarnot, D., Inform. Midem 38, 252 (2008)
[10]Wang, M.J., Chang, Y.I., Poncin-Epaillard, F., Surf. Interface Anal. 37, 348 (2005)
[11]Medard, N., Soutif, J.-C., Poncin-Epaillard, F., Langmuir 18, 2246 (2002)
[12]Coen, C., Keller, B., Groening, P., Schlapbach, L., J. Appl. Phys. 92, 5077 (2002)
[13]Wang, M.J., Chang, Y.I., Poncin-Epaillard, F., Langmuir 19, 8325 (2003)
[14]Ramires, P.A., Mirenghi, L., Romano, A.R., Palumbo, F., Nicolardi, G., J. Biomed. Mater. Res. 51, 535 (2000)
[15]Vesel, A., Junkar, I., Cvelbar, U., Kovac, J., Mozetic, M., Surf. Interface Anal. 40, 1444 (2008)
[16]Jaganjac, M., Matijevic, T., Cindric, M., Cipak, A., Mrakovcic, L., Gubisch, W., Zarkovic, N., Acta Biochim. Pol. 57, 179 (2010)
[17]Vesel, A., Surf. Coat. Technol. 205, 490 (2010)
[18]Oran, U., Swaraj, S., Friedrich, J.F., Unger, W.E.S., Plasma Process. Polym. 1, 141 (2004)
[19]Dilks, A., J. Polym. Sci. A: Polym. Chem. 19, 1319 (1981)
[20]Joshi, R., Schulze, R.-D., Meyer-Plath, A., Friedrich, J.F., Plasma Process. Polym. 5, 695 (2008)
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The European Physical Journal - Applied Physics
  • ISSN: 1286-0042
  • EISSN: 1286-0050
  • URL: /core/journals/the-european-physical-journal-applied-physics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed