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GENESiS: creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings

  • PC Sham (a1), A Sterne (a2), S Purcell (a3), S Cherny (a4), M Webster (a5), F Rijsdijk (a6), P Asherson (a7), D Ball (a8), I Craig (a9), T Eley (a10), D Goldberg (a11), J Gray (a12), A Mann (a13), M Owen (a14) and R Plomin (a15)...
Abstract
Abstract

There is considerable evidence for a unitary and dimensional view of the genetic vulnerability to symptoms of anxiety and depression. The GENESiS (Genetic Environmental–Nature of Emotional States in Siblings) Study aims to use a multivariate approach to detect genetic loci that contribute to individual differences in this vulnerability dimension. The study used the UK General Practice Research Framework to generate a community-based sample of siblings. Questionnaire measures of anxiety/depression included the short form of the neuroticism scale from the revised Eysenck Personality Questionnaire (EPQ-N), the General Health Questionnaire (GHQ-12), and the anxious arousal and high positive affect subscales from the Mood and Anxiety Symptoms Questionnaire (MASQ-AA and MASQ-HPA). Genetic model-fitting of 2658 unselected sibships provided evidence for a single common genetic (familial) factor that accounted for a substantial proportion of the genetic variances and covariances of these four measures. Using the parameter estimates of this model, we constructed a composite index of this common genetic factor. This index, which has a sib correlation of 0.22, will be used as a quantitative phenotype in the molecular genetic phase of GENESiS. Twin Research (2000) 3, 316–322.

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Copyright
Corresponding author
*Correspondence: Dr PC Sham, SGDP Research Centre, Institute of Psychiatry, London, SE5 8AF UK. Tel: 020 7848 0892; Fax: 020 7848 0866
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Twin Research and Human Genetics
  • ISSN: 1832-4274
  • EISSN: 1839-2628
  • URL: /core/journals/twin-research-and-human-genetics
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