Skip to main content
×
×
Home

Genetic and Environmental Factors in Complex Diseases: The Older Finnish Twin Cohort

  • Jaakko Kaprio (a1) and Markku Koskenvuo (a2)
Abstract

In studies on the Finnish Twin Cohort, we investigate genetic and environmental determinants of common, complex diseases, and their behavioral risk factors in Finland, a genetically unique and culturally homogenous population. We have formed the following databases: 1) Like-sexed twin pairs (13,888 pairs of known zygosity) form the older Twin Cohort. They have participated since 1975 in mail surveys, in clinical examinations for subsamples, and have been followed-up for morbidity using national medical registers; 2) The older Twin Cohort was expanded in 1996 to include opposite-sex pairs born 1938–1957 (c. 8000 pairs); 3) Two, new longitudinal studies of adolescent twins and their families, form a complementary, ongoing study base described in more detail in an accompanying article. Genetic and environmental effects vary over the life-span, and only longitudinal studies in genetically informative data sets permits the evaluation of such effects. Finally, the inclusion of DNA-based genetic information in a phenotypically rich family data base will offer a unique resource for research in genetic epidemiology and behavioral medicine.

Copyright
Corresponding author
*Address for correspondence: Jaakko Kaprio, Professor of Public Health, Dept. of Public Health, University of Helsinki, PO Box 41, FIN-00014 Helsinki, Finland.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Twin Research and Human Genetics
  • ISSN: 1832-4274
  • EISSN: 1839-2628
  • URL: /core/journals/twin-research-and-human-genetics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 3
Total number of PDF views: 201 *
Loading metrics...

Abstract views

Total abstract views: 696 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 15th July 2018. This data will be updated every 24 hours.