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    Cornes, Belinda K. Medland, Sarah E. Ferreira, Manuel A. R. Morley, Katherine I. Duffy, David L. Heijmans, Bastiaan T. Montgomery, Grant W. and Martin, Nicholas G. 2005. Sex-Limited Genome-Wide Linkage Scan for Body Mass Index in an Unselected Sample of 933 Australian Twin Families. Twin Research and Human Genetics, Vol. 8, Issue. 06, p. 616.


    Silventoinen, Karri Sammalisto, Sampo Perola, Markus Boomsma, Dorret I. Cornes, Belinda K. Davis, Chayna Dunkel, Leo de Lange, Marlies Harris, Jennifer R. Hjelmborg, Jacob V.B. Luciano, Michelle Martin, Nicholas G. Mortensen, Jakob Nisticò, Lorenza Pedersen, Nancy L. Skytthe, Axel Spector, Tim D. Stazi, Maria Antonietta Willemsen, Gonneke and Kaprio, Jaakko 2003. Heritability of Adult Body Height: A Comparative Study of Twin Cohorts in Eight Countries. Twin Research, Vol. 6, Issue. 5, p. 399.


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Height Discordance in Monozygotic Females is not Attributable to Discordant Inactivation of X-linked Stature Determining Genes

  • S.C. Healey (a1), K.M. Kirk (a2), V.J. Hyland (a3), C.F. Munns (a4), A.K. Henders (a5), J.A. Batch (a6), A.C. Heath (a7), N.G. Martin (a8) and I.A. Glass (a9)
  • DOI: http://dx.doi.org/10.1375/twin.4.1.19
  • Published online: 01 February 2012
Abstract
Abstract

We tested the hypothesis that X-linked genes determining stature which are subject to skewed or non-random X-inactivation can account for discordance in height in monozygotic female twins. Height discordant female monozygotic adult twins (20 pairs) were identified from the Australian Twin Registry, employing the selection criteria of proven monozygosity and a measured height discordance of at least 5 cm. Differential X-inactivation was examined in genomic DNA extracted from peripheral lymphocytes by estimating differential methylation of alleles at the polymorphic CAG triplet repeat of the Androgen receptor gene (XAR). There were 17/20 MZ pairs heterozygous at this locus and informative for analysis. Of these, 10/17 both had random X-inactivation, 5/17 showed identical X-inactivation patterns of non random inactivation and 2/17 (12%) showed discordant X-inactivation. There was no relationship between inactivation patterns and self-report chorionicity. We conclude that non-random X-inactivation does not appear to be a major contributor to intra-pair height discordance in female MZ twins.

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Copyright
Corresponding author
*Address for Correspondence: Dr Nicholas G. Martin, Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Post Office, Royal Brisbane Hospital, Brisbane QLD 4029, Australia.
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Twin Research and Human Genetics
  • ISSN: 1832-4274
  • EISSN: 1839-2628
  • URL: /core/journals/twin-research-and-human-genetics
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