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Infant zygosity can be assigned by parental report questionnaire data

Published online by Cambridge University Press:  21 February 2012

Thomas S Price*
Affiliation:
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UKt.price@iop.kcl.ac.uk
Bernard Freeman
Affiliation:
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
Ian Craig
Affiliation:
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
Stephen A Petrill
Affiliation:
Wesleyan University, Middletown, CT, USA
Lorna Ebersole
Affiliation:
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
Robert Plomin
Affiliation:
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK
*
*Correspondence: Thomas S Price, Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, SE5 8AF, UK. Tel: + 44 (0) 207 848 0961; Fax: + 44 (0) 207 848 0866

Abstract

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A parental report questionnaire posted to a population sample of 18-month-old twins correctly assigned zygosity in 95%of cases when validated against zygosity determined by identity of polymorphic DNA markers. The questionnaire was as accurate when readministered at 3 years of age, with 96% of children being assigned the same zygosity on both occasions. The results validate the use of parental report questionnaire data to determine zygosity in infancy. Twin Research (2000) 3, 129–133.

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Copyright © Cambridge University Press 2000
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