Skip to main content Accessibility help
×
Home
Hostname: page-component-55b6f6c457-b6fb2 Total loading time: 0.245 Render date: 2021-09-24T18:05:14.008Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Major Depression and the Metabolic Syndrome

Published online by Cambridge University Press:  21 February 2012

Debra L. Foley*
Affiliation:
Biostatistics Unit, Orygen Youth Health Research Centre & Centre for Youth Mental Health, The University of Melbourne, Australia. dfoley@unimelb.edu.au
Katherine I. Morley
Affiliation:
Statistical and Computational Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom & Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Australia.
Pamela A. F. Madden
Affiliation:
Department of Psychiatry, Washington University School of Medicine, United States of America.
Andrew C. Heath
Affiliation:
Department of Psychiatry, Washington University School of Medicine, United States of America.
John B. Whitfield
Affiliation:
Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Brisbane, Australia.
Nicholas G. Martin
Affiliation:
Genetic and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Brisbane, Australia.
*
*Address for correspondence: Debra Foley, Orygen Youth Health Research Centre, 35 Poplar Road, Parkville VIC 3052, Australia.

Abstract

HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The aim of this study is to characterize the relationship between major depression and the metabolic syndrome in a large community based sample of Australian men and women aged 26–90 years. A lifetime history of major depression was assessed by telephone interview following the DSM–III-R. A current history of metabolic syndrome was assessed following the United States National Cholesterol Education Program Adult Treatment Panel III (NCEP AP-III) guidelines 1 to 3 years later. Logistic regression was used to estimate the association between depression and the metabolic syndrome, and its component criteria, controlling for age, sex and alcohol dependence. There was no association between a lifetime history of major depression and the presence of the metabolic syndrome. There was a weak association between depression and low high-density lipoprotein cholesterol but not with other component criteria of the metabolic syndrome. Despite calls for interventions directed at depression to reduce the onset of the metabolic syndrome there are important failures to replicate in large samples such as this, no consensus regarding the threshold at which depression may pose a significant risk even allowing for heterogeneity across populations, and no consensus regarding confounders that may explain inter-study differences. The absence of any dosage effect of depression on the associated risk for the metabolic syndrome in other unselected samples does not support a direct causal relationship. The call for intervention studies on the basis of the currently published evidence base is unwarranted.

Type
Articles
Copyright
Copyright © Cambridge University Press 2010
You have Access
39
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Major Depression and the Metabolic Syndrome
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Major Depression and the Metabolic Syndrome
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Major Depression and the Metabolic Syndrome
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *