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The Michigan State University Twin Registry (MSUTR): An Update

  • S. Alexandra Burt (a1) and Kelly L. Klump (a1)
Abstract

The primary aim of the Michigan State University Twin Registry (MSUTR) is on understanding developmental changes in genetic, environmental, and neurobiological influences on internalizing and externalizing disorders, with antisocial behavior and disordered eating representing our particular areas of interest. The MSUTR has two broad components: a large-scale, population-based registry of child, adolescent, and adult twins and their families (current N ~20,000) and a series of more focused and in-depth studies drawn from the registry (current N ~4,000). Participants in the population-based registry complete a family health and demographic questionnaire via mail. Families are then recruited for one or more of the intensive, in-person studies from the population-based registry based on their answers to relevant items in the registry questionnaire. These in-person assessments target a variety of biological, genetic, and environmental phenotypes, including multi-informant measures of psychiatric and behavioral phenotypes, census and neighborhood informant reports of twin neighborhood characteristics, buccal swab and salivary DNA samples, assays of adolescent and adult steroid hormone levels, and/or videotaped interactions of child twin families. This article provides an overview of the MSUTR and describes current and future research directions.

Copyright
Corresponding author
address for correspondence: S. Alexandra Burt, Department of Psychology. Michigan State University, 107D Psychology Building, East Lansing, MI 48824-1116. E-mail: burts@msu.edu
References
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American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text revision, DSM-IV-TR). Washington, DC: Author.
Bulik, C. M. (2002). Eating disorders in adolescents and young adults. Child and Adolescent Psychiatric Clinics, 11, 201218.
Burt, S. A. (2010). Are there shared environmental influences on attention-deficit/hyperactivity disorder? Reply to Wood, Buitelaar, Rijsdijk, Asherson, and Kuntsi (2010). Psychological Bulletin, 136, 341343.
Burt, S. A. (2012). How do we optimally conceptualize the heterogeneity within antisocial behavior? An argument for aggressive versus non-aggressive behavioral dimensions. Clinical Psychology Review, 32, 263279.
Burt, S. A. (in press). Evidence for meaningful etiological distinctions within the broader construct of antisocial behavior. In Rhee, S. H. & Ronald, A. (Eds.), Behavior genetics of psychopathology. New York: Springer.
Burt, S. A., & Klump, K. L. (2009). The etiological moderation of aggressive and non-aggressive antisocial behavior by age. Twin Research & Human Genetics, 12, 343350.
Burt, S. A., & Klump, K. L. (2012). Etiological distinctions between aggressive and non-aggressive antisocial behavior: Results from a nuclear twin family model. Journal of Abnormal Child Psychology, 40, 10591071.
Burt, S. A., & Klump, K. L. (in press-a). Delinquent peer affiliation as an etiological moderator of childhood delinquency. Psychological Medicine.
Burt, S. A., & Klump, K. L. (in press-c). How does the inclusion of twins conceived via fertility treatments influence the results of twin studies? Twin Research and Human Genetics.
Burt, S. A., Larsson, H., Lichtenstein, P., & Klump, K. L. (2012). Additional evidence against shared environmental contributions to Attention-Deficit/Hyperactivity Problems. Behavior Genetics, 42, 711721.
Burt, S. A., McGue, M., Demarte, J. A., Krueger, R. F., & Iacono, W. G. (2006). Timing of menarche and the origins of conduct disorder. Archives of General Psychiatry, 63, 890896.
Burt, S. A., & Neiderhiser, J. M. (2009). Aggressive versus non-aggressive antisocial behavior: Distinctive etiological moderation by age. Developmental Psychology, 45, 11641176.
Culbert, K. M., Breedlove, S. M., Burt, S. A., & Klump, K. L. (2008). Prenatal hormone exposure and risk for eating disorders: A comparison of opposite- and same-sex twins. Archives of General Psychiatry, 65, 329336.
Culbert, K. M., Breedlove, S. M., Sisk, C. L., Burt, S. A., & Klump, K. L. (submitted). The emergence of sex differences in risk for disordered eating attitudes and behaviors during puberty: A role for prenatal testosterone exposure.
Culbert, K. M., Burt, S. A., McGue, M., Iacono, W. G., & Klump, K. L. (2009). Puberty and the genetic diathesis of disordered eating attitudes and behaviors. Journal of Abnormal Psychology, 118, 788796.
Donnellan, M. B., Burt, S. A., Levendosky, A. A., & Klump, K. L. (2008). Genes, personality, and attachment in adults: A multivariate behavioral genetic analysis. Personality and Social Psychology Bulletin, 34, 316.
Eggert, J., Levendosky, A. A., & Klump, K. L. (2007). Relationships among attachment styles, personality characteristics, and disordered eating. International Journal of Eating Disorders, 40, 149155.
Gobrogge, K. L., Breedlove, S. M., & Klump, K. L. (2008). Genetic and environmental influences on 2D:4D finger length ratios: A study of monozygotic and dizygotic male and female twins. Archives of Sexual Behavior, 37, 112118.
Goodman, R., & Scott, S. (1999). Comparing the strengths and difficulties questionnaire and the child behavior checklist: Is small beautiful? Journal of Abnormal Child Psychology, 27, 1724.
Graber, J., Brooks-Gunn, J., Paikoff, R., & Warren, M. (1994). Prediction of eating problems: An 8-year study of adolescent girls. Developmental Psychology, 30, 823834.
Harrell, Z. A. T., Slane, J. D., & Klump, K. L. (2009). Predictors of alcohol problems in college women: The role of depressive symptoms, disordered eating, and family history of alcoholism. Addictive Behaviors, 34, 252257.
Hopwood, J., Keel, P. K., Burt, S. A., Neale, M., Boker, S., & Sisk, C. L., et al. (in press). Interpersonal problems associated with Multidimensional Personality Questionnaire traits in women during the transition to adulthood. Assessment.
Humbad, M. N., Donnellan, M. B., Klump, K. L., & Burt, S. A. (2011). Development of the Brief Romantic Relationship Interaction Coding Scheme (BRRICS). Journal of Family Psychology, 25, 759769.
Iacono, W. G., Carlson, S. R., Taylor, J., Elkins, I. J., & McGue, M. (1999). Behavioral disinhibition and the development of substance use disorders: Findings from the Minnesota Twin Family Study. Development and Psychopathology, 11, 869900.
Killen, J., Hayward, C., Hammer, L., Wilson, D., Miner, B., & Taylor, C. (1992). Is puberty a risk factor for eating disorders? American Journal of Disorders of Childhood, 146, 323325.
Klahr, A. M., Thomas, K. M., Hopwood, C. J., Klump, K. L., & Burt, S. A. (in press). Evocative gene-environment correlation in the mother-child relationship: A twin study of interpersonal processes. Development & Psychopathology.
Klump, K. L., Burt, S. A., McGue, M., & Iacono, W. G. (2007). Changes in genetic and environmental influences on disordered eating across adolescence: A longitudinal twin study. Archives of General Psychiatry, 64, 14091415.
Klump, K. L., Culbert, K. M., Edler, C., & Keel, P. K. (2008). Ovarian hormones and binge eating: Exploring associations in community samples. Psychological Medicine, 38, 17491757.
Klump, K. L., Culbert, K. M., Slane, J. D., Burt, S. A., Sisk, C. L., & Nigg, J. T. (2012). The effects of puberty on genetic risk for disordered eating: Evidence for sex difference. Psychological Medicine, 42, 627638.
Klump, K. L., Keel, K., Racine, S. E., Burt, S. A., Neale, M., Sisk, C. L., . . . Hu, J. Y. (submitted). Ovarian hormones and emotional eating across the menstrual cycle: An examination of the potential moderating effects of body mass index and dietary restraint.
Klump, K. L., Keel, P. K., Racine, S. E., Burt, S. A., Neale, M., Sisk, C. L., . . . Hu, J. Y. (in press). The interactive effects of estrogen and progesterone on chagnes in emotional eating across the menstrual cycle. Journal of Abnormal Psychology.
Klump, K. L., Keel, P. K., Sisk, C. L., & Burt, S. A. (2010). Preliminary evidence that estradiol moderates genetic influences on disordered eating attitudes and behaviors during puberty. Psychological Medicine, 40, 17451753.
Klump, K. L., McGue, M., & Iacono, W. G. (2000). Age differences in genetic and environmental influences on eating attitudes and behaviors in female adolescent twins. Journal of Abnormal Psychology, 109, 239251.
Klump, K. L., McGue, M., & Iacono, W. G. (2003). Differential heritability of eating pathology in pre-pubertal versus pubertal twins. International Journal of Eating Disorders, 33, 287292.
Lykken, D. T., Bouchard, T. J., McGue, M., & Tellegen, A. (1990). The Minnesota Twin Family Registry: Some initial findings. Acta Gemellogicae et Medicae, 39, 3570.
Marceau, K., Humbad, M. N., Burt, S. A., Klump, K. L., Leve, L. D., & Neiderhiser, J. M. (2012). Observed externalizing behavior: A developmental comparison of genetic and environmental influences across three samples. Behavior Genetics, 42, 3039.
Moffitt, T. E. (2003). Life-course persistent and adolescence-limited antisocial behavior: A research review and a research agenda. In Lahey, B., Moffitt, T. E. & Caspi, A. (Eds.), The causes of conduct disorder and serious juvenile delinquency (pp. 4975). New York: Guilford.
Moore, M., Slane, J. D., Mindell, J. A., Burt, S. A., & Klump, K. L. (2011a). Sleep problems and temperament in adolescents. Child: Health, Care, and Development, 37, 559562.
Moore, M., Slane, J. D., Mindell, J. A., & Klump, K. L. (2011b). Genetic and environmental influences on sleep problems: A study of preadolescent and adolescent twins. Child: Health, Care, and Development, 5, 638641.
Moser, J., Slane, J. D., Burt, S. A., & Klump, K. L. (2012). Etiologic relationships betwee anxiety and dimensions of maladaptive perfectionism in young adult females. Depression and Anxiety, 29, 4753.
Nikolas, M., Klump, K. L., & Burt, S. A. (2012). The impact of youth appraisals of marital conflict on genetic and environmental contributions to attention-deficit hyperactivity disorder: Examination of G × E effects in a twin sample. Journal of Abnormal Child Psychology, 40, 543554.
Nikolas, M., Klump, K. L., & Burt, S. A. (in press). Etiological contributions to the covariation between children's perception of interparental conflict and child behavioral problems. Journal of Abnormal Child Psychology.
Peeters, H., Van Gestel, S., Vlietinck, R., Derom, C., & Derom, R. (1998). Validation of a telephone zygosity questionnaire in twins of known zygosity. Behavior Genetics, 28, 159–161.
Racine, S. E., Burt, S. A., & Klump, K. L. (2011). Dietary restraint moderates genetic risk for binge eating. Journal of Abnormal Psychology, 120, 119128.
Racine, S. E., Culbert, K. M., Burt, S. A., & Klump, K. L. (submitted-a). Advanced paternal age at birth: Phenotypic and etiologic associations with eating disorder risk in offspring.
Racine, S. E., Culbert, K. M., Burt, S. A., & Klump, K. L. (submitted-b). Exploring the relationship between negative urgency and binge eating: Etiologic associations and the role of negative affect.
Racine, S. E., Culbert, K. M., Keel, P. K., Sisk, C. L., Burt, S. A., & Klump, K. L. (2012). Differential associations between ovarian hormones and disordered eating symptoms across the menstrual cycle in women. International Journal of Eating Disorders, 45, 333344.
Slane, J. D., Burt, S. A., & Klump, K. L. (2010). The road less traveled: Influences of externalizing behaviors on eating pathology. International Journal of Eating Disorders, 43, 149160.
Slane, J. D., Burt, S. A., & Klump, K. L. (2011). Genetic and environmental influences on disordered eating and depressive symptoms. International Journal of Eating Disorders, 44, 605611.
Slane, J. D., Burt, S. A., & Klump, K. L. (2012). Bulimic behaviors and alcohol use: Shared genetic influences. Behavior Genetics, 42, 603613.
Spanos, A., Burt, S. A., & Klump, K. L. (2010). Do weight and shape concerns exhibit genetic effects? Investigating discrepant findings. International Journal of Eating Disorders, 43, 2934.
Stanger, C., Achenbach, T. A., & Verhulst, F. C. (1997). Acceleratred longitiudinal comparisons of aggressive versus deliquent syndromes. Development and Psychopathology, 9, 4358.
Suisman, J. L., O'Connor, S. M., Sperry, S., Thompson, J. K., Keel, P. K., Burt, S. A., . . . Klump, K. L. (in press). Genetic and environmental influences on thin-ideal internalization. International Journal of Eating Disorders.
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Twin Research and Human Genetics
  • ISSN: 1832-4274
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