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SNP Sets and Reading Ability: Testing Confirmation of a 10-SNP Set in a Population Sample

Published online by Cambridge University Press:  21 February 2012

Michelle Luciano ,
Grant W. Montgomery ,
Nicholas G. Martin ,
Margaret J. Wright  and
Timothy C. Bates
Michelle Luciano*
Affiliation:
Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, United Kingdom. michelle.luciano@ed.ac.uk
Grant W. Montgomery
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia.
Nicholas G. Martin
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia.
Margaret J. Wright
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia.
Timothy C. Bates*
Affiliation:
Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, United Kingdom; Queensland Institute of Medical Research, Brisbane, Australia. tim.bates@ed.ac.uk
*
1ADDRESS FOR CORRESPONDENCE: Dr Michelle Luciano, Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, United Kingdom.
2ADDRESS FOR CORRESPONDENCE: Professor Timothy Bates, Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, United Kingdom.

Abstract

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A set of 10 SNPs associated with reading ability in 7-year-olds was reported based on initial pooled analyses of 100K SNP chip data, with follow-up testing stages using pooling and individual testing. Here we examine this association in an adolescent population sample of Australian twins and siblings (N = 1177) aged 12 to 25 years. One (rs1842129) of the 10 SNPs approached significance (P = .05) but no support was found for the remaining 9 SNPs or the SNP set itself. Results indicate that these SNPs are not associated with reading ability in an Australian population. The results are interpreted as supporting use of much larger SNP sets in common disorders where effects are small.

Keywords

dyslexiaassociationGWASnormal readinggenes
Type
Articles
Information
Twin Research and Human Genetics , Volume 14 , Issue 3 , 01 June 2011 , pp. 228 - 232
Copyright
Copyright © Cambridge University Press 2011