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The Swedish Twin Registry: Establishment of a Biobank and Other Recent Developments

  • Patrik K. E. Magnusson (a1), Catarina Almqvist (a1) (a2), Iffat Rahman (a1), Andrea Ganna (a1), Alexander Viktorin (a1), Hasse Walum (a1), Linda Halldner (a1) (a3), Sebastian Lundström (a4) (a5) (a6), Fredrik Ullén (a7), Niklas Långström (a1) (a5), Henrik Larsson (a1), Anastasia Nyman (a1), Clara Hellner Gumpert (a8), Maria Råstam (a9), Henrik Anckarsäter (a4), Sven Cnattingius (a10), Magnus Johannesson (a11), Erik Ingelsson (a1), Lars Klareskog (a12), Ulf de Faire (a13), Nancy L. Pedersen (a1) and Paul Lichtenstein (a1)...

Abstract

The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from 15,000 twins, which effectively has also transformed the registry into a powerful resource for molecular studies. We here describe the main projects within which the new collections of both biological samples as well as phenotypic measures have been collected. Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described.

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Copyright

Corresponding author

address for correspondence: Patrik K. E. Magnusson, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 17177 Stockholm, Sweden. E-mail: patrik.magnusson@ki.se

References

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Altman, D., Lundholm, C., Milsom, I., Peeker, R., Fall, M., Iliadou, A. N., & Pedersen, N. L. (2011). The genetic and environmental contribution to the occurrence of bladder pain syndrome: An empirical approach in a nationwide population sample. European Urology, 59, 280285.
Anckarsater, H., Lundstrom, S., Kollberg, L., Kerekes, N., Palm, C., Carlstrom, E., . . . Lichtenstein, P. (2011). The Child and Adolescent Twin Study in Sweden (CATSS). Twin Research and Human Genetics, 14, 495508.
Benjamin, D. J., Cesarini, D., van der Loos, M. J., Dawes, C. T., Koellinger, P. D., Magnusson, P. K., . . . Visscher, P. M. (2012). The genetic architecture of economic and political preferences. Proceedings of the National Academy of Sciences, 109, 80268031.
Bergvall, N., Iliadou, A., Johansson, S., de Faire, U., Kramer, M. S., Pawitan, Y., . . . Cnattingius, S. (2007). Genetic and shared environmental factors do not confound the association between birth weight and hypertension: A study among Swedish twins. Circulation, 115, 29312938.
Cederlöf, R. (1966). The twin method in epidemiological studies on chronic disease. Unpublished doctoral dissertation, Karolinska Institutet, Sweden.
Cesarini, D., Johannesson, M., Magnusson, P. K., & Wallace, B. (2012). The behavioral genetics of behavioral anomalies. Management Science, 58, 2134
EuroQol. (1990). EuroQol — A new facility for the measurement of health-related quality of life. The EuroQol Group. Health Policy, 16, 199208.
Formann, A. K., & Piswanger, K. (1979). WMT — Wiener Matrizentest. Manual. Weinheim: Beltz Test Gesellschaft.
Furberg, H., Lichtenstein, P., Pedersen, N. L., Thornton, L., Bulik, C. M., Lerman, C., & Sullivan, P. F. (2008). The STAGE cohort: A prospective study of tobacco use among Swedish twins. Nicotine & Tobacco Research, 10, 17271735.
Gold, C. H., Malmberg, B., McClearn, G. E., Pedersen, N. L., & Berg, S. (2002). Gender and health: A study of older unlike-sex twins. Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 57, S168S176.
Hannelius, U., Gherman, L., Makela, V. V., Lindstedt, A., Zucchelli, M., Lagerberg, C., . . . Lindgren, C. M. (2007). Large-scale zygosity testing using single nucleotide polymorphisms. Twin Research & Human Genetics, 10, 604625.
Hansson, S. L., Svanstrom Rojvall, A., Rastam, M., Gillberg, C., & Anckarsater, H. (2005). Psychiatric telephone interview with parents for screening of childhood autism — Tics, attention-deficit hyperactivity disorder and other comorbidities (A-TAC): Preliminary reliability and validity. British Journal of Psychiatry, 187, 262267.
Harris, C. R. (2003). Factors associated with jealousy over real and imagined infidelity: An examination of the social-cognitive and evolutionary psychology perspectives. Psychology of Women Quarterly, 4, 319329.
Heath, A. C., Nyholt, D. R., Neuman, R., Madden, P. A., Bucholz, K. K., Todd, R. D., . . . Martin, N. G. (2003). Zygosity diagnosis in the absence of genotypic data: An approach using latent class analysis. Twin Research, 6, 2226.
Hedelin, M., Lof, M., Olsson, M., Lewander, T., Nilsson, B., Hultman, C. M., & Weiderpass, E. (2010). Dietary intake of fish, omega-3, omega-6 polyunsaturated fatty acids and vitamin D and the prevalence of psychotic-like symptoms in a cohort of 33,000 women from the general population. BMC Psychiatry, 10 (38), 113.
Hoekstra, C., Willemsen, G., van Beijsterveldt, C. E., Lambalk, C. B., Montgomery, G. W., & Boomsma, D. I. (2010). Body composition, smoking, and spontaneous dizygotic twinning. Fertility and Sterility, 93, 885893.
Hoekstra, C., Zhao, Z. Z., Lambalk, C. B., Willemsen, G., Martin, N. G., Boomsma, D. I., & Montgomery, G. W. (2008). Dizygotic twinning. Human Reproduction Update, 14, 3747.
Holm, L., Ullen, F., & Madison, G. (2011). Intelligence and temporal accuracy of behaviour: Unique and shared associations with reaction time and motor timing. Experimental Brain Research, 214, 175183.
Humphreys, K., Grankvist, A., Leu, M., Hall, P., Liu, J., Ripatti, S., . . . Magnusson, P. K. (2011). The genetic structure of the Swedish population. PLoS One, 6, e22547.
Karlstrom, P. O., & Bergh, C. (2007). Reducing the number of embryos transferred in Sweden-impact on delivery and multiple birth rates. Human Reproduction, 22, 22022207.
Larson, T., Anckarsater, H., Gillberg, C., Stahlberg, O., Carlstrom, E., Kadesjo, B., . . . Lichtenstein, P. (2010). The Autism — Tics, AD/HD and Other Comorbidities Inventory (A-TAC): Further validation of a telephone interview for epidemiological research. BMC Psychiatry, 10 (1), 111.
Lichtenstein, P., De Faire, U., Floderus, B., Svartengren, M., Svedberg, P., & Pedersen, N. L. (2002). The Swedish Twin Registry: A unique resource for clinical, epidemiological and genetic studies. Journal of Internal Medicine, 252, 184205.
Lichtenstein, P., Sullivan, P. F., Cnattingius, S., Gatz, M., Johansson, S., Carlstrom, E., . . . Pedersen, N. L. (2006). The Swedish Twin Registry in the third millennium: An update. Twin Research & Human Genetics, 9, 875882.
Lichtenstein, P., Tuvblad, C., Larsson, H., & Carlstrom, E. (2007). The Swedish Twin study of CHild and Adolescent Development: The TCHAD-study. Twin Research & Human Genetics, 10, 6773.
Lundholm, C., Ortqvist, A. K., Lichtenstein, P., Cnattingius, S., & Almqvist, C. (2010). Impaired fetal growth decreases the risk of childhood atopic eczema: A Swedish twin study. Clinical & Experimental Allergy, 40, 10441053.
Medlund, P., Cederlof, R., Floderus-Myrhed, B., Friberg, L., & Sorensen, S. (1976). A new Swedish twin registry containing environmental and medical base line data from about 14,000 same-sexed pairs born 1926–58. Acta Medica Scandinavica, Supplementum, 600, 1111.
Meltzer-Brody, S., Zerwas, S., Leserman, J., Holle, A. V., Regis, T., & Bulik, C. (2011). Eating disorders and trauma history in women with perinatal depression. Journal Womens Health (Larchmt), 20, 863870.
Mosing, M. A., Magnusson, P. K, Pedersen, N. L., Nakamura, J., Madison, G., & Ullén, F. (2012). Heritability of proneness for psychological flow experiences. Personality and Individual Differences, 53, 699704.
Muthén, L. K., & Muthén, B. O. (2006). Mplus user's guide. Los Angeles, CA: Muthén & Muthén.
Nyman, T., Mulder, M., Iliadou, A., Svartengren, M., & Wiktorin, C. (2009). Physical workload, low back pain and neck-shoulder pain: A Swedish twin study. Occupational and Environmental Medicine, 66, 395401.
Oberg, S., Cnattingius, S., Sandin, S., Lichtenstein, P., & Iliadou, A. N. (2011). Birth weight predicts risk of cardiovascular disease within dizygotic but not monozygotic twin pairs: A large population-based co-twin-control study. Circulation, 123, 27922798.
Ortqvist, A. K., Lundholm, C., Carlstrom, E., Lichtenstein, P., Cnattingius, S., & Almqvist, C. (2009). Familial factors do not confound the association between birth weight and childhood asthma. Pediatrics, 124, e737e743.
Pedersen, N. L., Lichtenstein, P., & Svedberg, P. (2002). The Swedish Twin Registry in the third millennium. Twin Research, 5, 427432.
Price, A. L., Zaitlen, N. A., Reich, D., & Patterson, N. (2010). New approaches to population stratification in genome-wide association studies. Nature Reviews Genetics, 11, 459463.
Rahman, I., Bennet, A. M., Pedersen, N. L., de Faire, U., Svensson, P., & Magnusson, P. K. (2009). Genetic dominance influences blood biomarker levels in a sample of 12,000 Swedish elderly twins. Twin Research & Human Genetics, 12, 286294.
Ripke, S., Sanders, A. R., Kendler, K. S., Levinson, D. F., Sklar, P., Holmans, P. A., . . . Gejman, P. V. (2011). Genome-wide association study identifies five new schizophrenia loci. Nature Genetics, 43, 969976.
Schuz, J., Elliott, P., Auvinen, A., Kromhout, H., Poulsen, A. H., Johansen, C., . . . Ahlbom, A. (2011). An international prospective cohort study of mobile phone users and health (Cosmos): Design considerations and enrolment. Cancer Epidemiology, 35, 3743.
Simpson, J. A., & Gangestad, S. W. (1991). Individual differences in sociosexuality: Evidence for convergent and discriminant validity. Journal of Personality and Social Psychology, 60, 870883.
Statistics-Sweden. (2011). Multi-generation register 2010: A description of contents and quality. Background facts on population and welfare statistics. Stockholm, Sweden: Author.
Ullén, F., de Manzano, Ö., Almeida, R., Magnusson, P. K., Pedersen, N. L., Nakamura, J., . . . Madison, G. (2012). Proneness for psychological flow in everyday life: Associations with personality and intelligence. Personality and Individual Differences, 52, 167172.
van Dongen, J., Slagboom, P. E., Draisma, H. H., Martin, N. G., & Boomsma, D. I. (2012). The continuing value of twin studies in the omics era. Nature Reviews Genetics, 13, 640653.
Walum, H., Westberg, L., Henningsson, S., Neiderhiser, J. M., Reiss, D., Igl, W., . . . Lichtenstein, P. (2008). Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans. Proceedings of the National Academy of Sciences of the United States of America, 105, 1415314156.
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Twin Research and Human Genetics
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