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Twins Early Development Study: A Genetically Sensitive Investigation into Behavioral and Cognitive Development from Infancy to Emerging Adulthood

  • Kaili Rimfeld (a1), Margherita Malanchini (a1) (a2), Thomas Spargo (a1), Gemma Spickernell (a1), Saskia Selzam (a1), Andrew McMillan (a1), Philip S. Dale (a3), Thalia C. Eley (a1) and Robert Plomin (a1)...

Abstract

The Twins Early Development Study (TEDS) is a longitudinal twin study that recruited over 16,000 twin-pairs born between 1994 and 1996 in England and Wales through national birth records. More than 10,000 of these families are still engaged in the study. TEDS was and still is a representative sample of the population in England and Wales. Rich cognitive and emotional/behavioral data have been collected from the twins from infancy to emerging adulthood, with data collection at first contact and at ages 2, 3, 4, 7, 8, 9, 10, 12, 14, 16, 18 and 21, enabling longitudinal genetically sensitive analyses. Data have been collected from the twins themselves, from their parents and teachers, and from the UK National Pupil Database. Genotyped DNA data are available for 10,346 individuals (who are unrelated except for 3320 dizygotic co-twins). TEDS data have contributed to over 400 scientific papers involving more than 140 researchers in 50 research institutions. TEDS offers an outstanding resource for investigating cognitive and behavioral development across childhood and early adulthood and actively fosters scientific collaborations.

Copyright

Corresponding author

Author for correspondence: Kaili Rimfeld, Email: kaili.rimfeld@kcl.ac.uk

References

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Ahmadzadeh, Y. I., Eley, T., Plomin, R., Dale, P., Lester, K. J., Oliver, B. R., … McAdams, T. A. (2019). Children of the Twins Early Development Study (CoTEDS): A Children-of-Twins Study. Twin Research and Human Genetics, 19. doi: 10.1017/thg.2019.61
Allegrini, A. G., Selzam, S., Rimfeld, K., von Stumm, S., Pingault, J. B., & Plomin, R. (2019). Genomic prediction of cognitive traits in childhood and adolescence. Molecular Psychiatry, 24, 819827.
Arnett, J. J. (2006). Emerging adulthood: The winding road from the late teens through the twenties. Oxford, UK: Oxford University Press.
Asbury, K., Moran, N., & Plomin, R. (2016). Nonshared environmental influences on academic achievement at age 16. AERA Open, 2, 112.
Ayorech, Z., Plomin, R., & von Stumm, S. (2019). Using DNA to predict educational trajectories in early adulthood. Developmental Psychology, 55, 10881095.
Cheesman, R., Purves, K. L., Pingault, J. B., Breen, G., Plomin, R., & Eley, T. C. (2018). Extracting stability increases the SNP heritability of emotional problems in young people. Translational Psychiatry, 8, 223.
Colledge, E., Bishop, D. V. M., Koeppen-Schomerus, G., Price, T. S., Happé, F. G. E., Eley, T. C., … Plomin, R. (2002). The structure of language abilities at 4 years: A twin study. Developmental Psychology, 38, 749757.
Dale, P. S., Harlaar, N., & Plomin, R. (2012). Nature and nurture in school-based second language achievement. Language Learning, 62, S28S48.
Eley, T. C., Gregory, A. M., Clark, D. M., & Ehlers, A. (2007). Feeling anxious: A twin study of panic/somatic ratings, anxiety sensitivity and heartbeat perception in children. Journal of Child Psychology and Psychiatry and Allied Disciplines, 48, 11841191.
Fearon, P., Shmueli-Goetz, Y., Viding, E., Fonagy, P., & Plomin, R. (2014). Genetic and environmental influences on adolescent attachment. Journal of Child Psychology and Psychiatry and Allied Disciplines, 55, 10331041.
Fraser, A., Macdonald-Wallis, C., Tilling, K., Boyd, A., Golding, J., Davey Smith, G., … Lawlor, D. A. (2013). Cohort profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort. International Journal of Epidemiology, 42, 97110.
Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2013). Twins Early Development Study (TEDS): A genetically sensitive investigation of cognitive and behavioral development from childhood to young adulthood. Twin Research and Human Genetics, 16, 117125.
Haworth, C. M. A., Harlaar, N., Kovas, Y., Davis, O. S. P., Oliver, B. R., Hayiou-Thomas, M. E., … Plomin, R. (2007). Internet cognitive testing of large samples needed in genetic research. Twin Research and Human Genetics, 10, 554563.
Kovas, Y., Haworth, C. M. A., Dale, P. S., & Plomin, R. (2007). The genetic and environmental origins of learning abilities and disabilities in the early school years. Monographs of the Society for Research in Child Development, 72, 1144.
Krapohl, E., Patel, H., Newhouse, S., Curtis, C. J., Von Stumm, S., Dale, P. S., … Plomin, R. (2018). Multi-polygenic score approach to trait prediction. Molecular Psychiatry, 23, 13681374.
Moayyeri, A., Hammond, C. J., Valdes, A. M., & Spector, T. D. (2012). Cohort profile: TwinsUK and healthy ageing twin study. International Journal of Epidemiology, 42, 7685.
Oliver, B., Dale, P. S., Saudino, K. J., Petrill, S. A., Pike, A., & Plomin, R. (2002). The validity of a parent-based assessment of cognitive abilities in three-year olds. Early Child Development and Care, 172, 337348.
Oliver, B., & Plomin, R. (2007). Twins’ Early Development Study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behavior problems from childhood through adolescence. Twin Research and Human Genetics, 10, 96105.
Petrill, S. A., Rempell, J., Oliver, B., & Plomin, R. (2002). Testing cognitive abilities by telephone in a sample of 6- to 8-year-olds. Intelligence, 30, 353360.
Price, T. S., Freeman, B., Craig, I., Petrill, S. A., Ebersole, L., & Plomin, R. (2000). Infant zygosity can be assigned by parental report questionnaire data. Twin Research, 3, 129133.
Rimfeld, K., Ayorech, Z., Dale, P. S., Kovas, Y., & Plomin, R. (2016). Genetics affects choice of academic subjects as well as achievement. Scientific Reports, 6, 26373.
Rimfeld, K., Malanchini, M., Hannigan, L. J., Dale, P. S., Allen, R., Hart, S. A., & Plomin, R. (2019). Teacher assessments during compulsory education are as reliable, stable and heritable as standardized test scores. Journal of Child Psychology and Psychiatry. Advance online publication. doi:10.1111/jcpp.13070
Rimfeld, K., Malanchini, M., Krapohl, E., Hannigan, L. J., Dale, P. S., & Plomin, R. (2018). The stability of educational achievement across school years is largely explained by genetic factors. NPJ Science of Learning, 3, Article No. 16.
Saudino, K. J., Dale, P. S., Oliver, B., Petrill, S. A., Richardson, V., Rutter, M., … Plomin, R. (1998). The validity of parent-based assessment of the cognitive abilities of 2-year-olds. British Journal of Developmental Psychology, 16, 349362.
Selzam, S., Coleman, J. R. I., Caspi, A., Moffitt, T. E., & Plomin, R. (2018). A polygenic p factor for major psychiatric disorders. Translational Psychiatry, 8, 205.
Selzam, S., Krapohl, E., von Stumm, S., O’Reilly, P. F., Rimfeld, K., Kovas, Y., … Plomin, R. (2017). Predicting educational achievement from DNA. Molecular Psychiatry, 22, 267272.
Selzam, S., McAdams, T. A., Coleman, J. R. I., Carnell, S., O’Reilly, P. F., Plomin, R., & Llewellyn, C. H. (2018). Evidence for gene-environment correlation in child feeding: Links between common genetic variation for BMI in children and parental feeding practices. PLoS Genetics, 14, e1007757.
Smith-Woolley, E., Ayorech, Z., Dale, P. S., von Stumm, S., & Plomin, R. (2018). The genetics of university success. Scientific Reports, 8, 14579.
Smith-Woolley, E., Pingault, J.-B., Selzam, S., Rimfeld, K., Krapohl, E., von Stumm, S., … Plomin, R. (2018). Differences in exam performance between pupils attending selective and non-selective schools mirror the genetic differences between them. NPJ Science of Learning, 3, Article No. 3.
Smith-Woolley, E., Selzam, S., & Plomin, R. (2019). Polygenic score for educational attainment captures DNA variants shared between personality traits and educational achievement. Journal of Personality and Social Psychology. Advance online publication. doi:10.1037/pspp0000241
Sudlow, C., Gallacher, J., Allen, N., Beral, V., Burton, P., Danesh, J., … Collins, R. (2015). UK Biobank: An open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Medicine, 12, e1001779.
Trouton, A., Spinath, F. M., & Plomin, R. (2002). Twins Early Development Study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood. Twin Research, 5, 444448.
Viding, E., Price, T. S., Spinath, F. M., Bishop, D. V. M., Dale, P. S., & Plomin, R. (2003). Genetic and environmental mediation of the relationship between language and nonverbal impairment in 4-year-old twins. Journal of Speech, Language, and Hearing Research, 46, 12711282.
Wardle, J., Guthrie, C., Sanderson, S., Birch, L., & Plomin, R. (2001). Food and activity preferences in children of lean and obese parents. International Journal of Obesity, 25, 971977.
Waszczuk, M. A., Zavos, H. M. S., Gregory, A. M., & Eley, T. C. (2014). The phenotypic and genetic structure of depression and anxiety disorder symptoms in childhood, adolescence, and young adulthood. JAMA Psychiatry, 71, 905916.
Zheng, Y., Plomin, R., & von Stumm, S. (2016). Heritability of intraindividual mean and variability of positive and negative affect: Genetic analysis of daily affect ratings over a month. Psychological Science, 27, 16111619.

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