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Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project

  • Aline Jelenkovic (a1) (a2), Yoshie Yokoyama (a3), Reijo Sund (a1), Chika Honda (a4), Leonie H Bogl (a5), Sari Aaltonen (a1) (a5), Fuling Ji (a6), Feng Ning (a6), Zengchang Pang (a6), Juan R. Ordoñana (a7) (a8), Juan F. Sánchez-Romera (a8) (a9), Lucia Colodro-Conde (a7) (a10), S. Alexandra Burt (a11), Kelly L. Klump (a11), Sarah E. Medland (a10), Grant W. Montgomery (a10), Christian Kandler (a12), Tom A. McAdams (a13), Thalia C. Eley (a13), Alice M. Gregory (a14), Kimberly J. Saudino (a15), Lise Dubois (a16), Michel Boivin (a17) (a18), Adam D. Tarnoki (a19), David L. Tarnoki (a19), Claire M. A. Haworth (a20), Robert Plomin (a13), Sevgi Y. Öncel (a21), Fazil Aliev (a22) (a23), Maria A. Stazi (a24), Corrado Fagnani (a24), Cristina D’Ippolito (a24), Jeffrey M. Craig (a25) (a26), Richard Saffery (a25) (a26), Sisira H. Siribaddana (a27) (a28), Matthew Hotopf (a29), Athula Sumathipala (a27) (a30), Fruhling Rijsdijk (a13), Timothy Spector (a31), Massimo Mangino (a31), Genevieve Lachance (a31), Margaret Gatz (a32) (a33), David A. Butler (a34), Gombojav Bayasgalan (a35), Danshiitsoodol Narandalai (a35) (a36), Duarte L Freitas (a37), José Antonio Maia (a38), K. Paige Harden (a39), Elliot M. Tucker-Drob (a39), Bia Kim (a40), Youngsook Chong (a40), Changhee Hong (a40), Hyun Jung Shin (a40), Kaare Christensen (a41) (a42), Axel Skytthe (a41), Kirsten O. Kyvik (a43) (a44), Catherine A. Derom (a45), Robert F. Vlietinck (a45), Ruth J. F. Loos (a46), Wendy Cozen (a47) (a48), Amie E. Hwang (a47), Thomas M. Mack (a47) (a48), Mingguang He (a49) (a50), Xiaohu Ding (a49), Billy Chang (a49), Judy L. Silberg (a51), Lindon J. Eaves (a51), Hermine H. Maes (a52), Tessa L. Cutler (a53), John L. Hopper (a53) (a54), Kelly Aujard (a55), Patrik K. E. Magnusson (a33), Nancy L. Pedersen (a33), Anna K. Dahl Aslan (a33) (a56), Yun-Mi Song (a57), Sarah Yang (a54) (a58), Kayoung Lee (a59), Laura A. Baker (a32), Catherine Tuvblad (a32) (a60), Morten Bjerregaard-Andersen (a61) (a62) (a63), Henning Beck-Nielsen (a63), Morten Sodemann (a64), Kauko Heikkilä (a5), Qihua Tan (a65), Dongfeng Zhang (a66), Gary E. Swan (a67), Ruth Krasnow (a68), Kerry L. Jang (a69), Ariel Knafo-Noam (a70), David Mankuta (a71), Lior Abramson (a70), Paul Lichtenstein (a33), Robert F. Krueger (a72), Matt McGue (a72), Shandell Pahlen (a72), Per Tynelius (a73), Glen E. Duncan (a74), Dedra Buchwald (a74), Robin P. Corley (a75), Brooke M. Huibregtse (a75), Tracy L. Nelson (a76), Keith E. Whitfield (a77), Carol E. Franz (a78), William S. Kremen (a78) (a79), Michael J. Lyons (a80), Syuichi Ooki (a81), Ingunn Brandt (a82), Thomas Sevenius Nilsen (a82), Fujio Inui (a4) (a83), Mikio Watanabe (a4), Meike Bartels (a84), Toos C. E. M. van Beijsterveldt (a84), Jane Wardle (a85), Clare H. Llewellyn (a85), Abigail Fisher (a85), Esther Rebato (a2), Nicholas G. Martin (a10), Yoshinori Iwatani (a4), Kazuo Hayakawa (a4), Joohon Sung (a54) (a58), Jennifer R. Harris (a82), Gonneke Willemsen (a84), Andreas Busjahn (a86), Jack H. Goldberg (a87), Finn Rasmussen (a73), Yoon-Mi Hur (a88), Dorret I. Boomsma (a84), Thorkild I. A. Sørensen (a20) (a89) (a90), Jaakko Kaprio (a5) (a91) (a92) and Karri Silventoinen (a1) (a4)...
Abstract

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.

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Corresponding author
address for correspondence: Aline Jelenkovic, Population Research Unit, Department of Social Research, University of Helsinki, PO Box 18, FIN-00014, Helsinki, Finland. E-mail: aline.jelenkovic@helsinki.fi
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L. Antoniades , A. J. MacGregor , T. Andrew , & T. D. Spector (2003). Association of birth weight with osteoporosis and osteoarthritis in adult twins. Rheumatology (Oxford, England), 42, 791796.

O. Basso , E. A. Nohr , K. Christensen , & J. Olsen (2004). Risk of twinning as a function of maternal height and body mass index. JAMA, 291, 15641566.

B. Benyamin , T. I. Sørensen , K. Schousboe , M. Fenger , P. M. Visscher , & K. O. Kyvik (2007). Are there common genetic and environmental factors behind the endophenotypes associated with the metabolic syndrome? Diabetologia, 50, 18801888.

I. Blickstein , L. G. Keith , & D. M. Keith (Eds.). (2005). Multiple pregnancy (2nd ed.). New York, NY: Taylor and Francis.

D. Boomsma , G. Willemsen , E. Geus , N. Kupper , D. Posthuma , R. Ijzerman , . . . C. Dolan (2005). Twins and the fetal origins hypothesis: An application to growth data. In Claude Kordon , Rolf-Christian Gaillard , & Yves Christen (Eds.), Hormones and the brain (pp. 2946). Berlin, Germany: Springer-Verlag.

J. M. Buckler , & M. Green (2004). A comparison of the early growth of twins and singletons. Annals of Human Biology, 31, 311332.

M. G. Bulmer (1970). The biology of twinning in man. Oxford, UK: Clarendon Press.

D. M. Campbell (2005). Natural factors influencing multiple gestation: Perspectives from long-term observations in Scotland. In I. Blickstein , L. G. Keith , & D. M. Keith (Eds.), Multiple pregnancy (2nd ed., pp. 8793). New York, NY: Taylor and Francis.

G. Corney , D. Seedburgh , B. Thompson , D. M. Campbell , I. MacGillivray , & D. Timlin (1979). Maternal height and twinning. Annals of Human Genetics, 43, 5559.

M. J. Davies , V. M. Moore , K. J. Willson , P. Van Essen , K. Priest , H. Scott . . . A. Chan (2012). Reproductive technologies and the risk of birth defects. New England Journal of Medicine, 366, 18031813.

J. Dube , L. Dodds , & B. A. Armson (2002). Does chorionicity or zygosity predict adverse perinatal outcomes in twins? American Journal of Obstetrics and Gynecology, 186, 579583.

W. Eriksen , J. M. Sundet , & K. Tambs (2013). Adult body height of twins compared with that of singletons: A register-based birth cohort study of Norwegian males. American Journal of Epidemiology, 177, 10151019.

G. F. Estourgie-van Burk , M. Bartels , D. I. Boomsma , & H. A. Delemarre-van de Waal (2010). Body size of twins compared with siblings and the general population: From birth to late adolescence. The Journal of Pediatrics, 156, 586591.

B. C. Fauser , P. Devroey , & N. S. Macklon (2005). Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet, 365, 18071816.

S. Helle , V. Lummaa , & J. Jokela (2004). Selection for increased brood size in historical human populations. Evolution: International Journal of Organic Evolution, 58, 430436.

J. B. Hjelmborg , T. Scheike , K. Holst , A. Skytthe , K. L. Penney , R. E. Graff , . . . L. A. Mucci (2014). The heritability of prostate cancer in the Nordic twin study of cancer. Cancer Epidemiology, Biomarkers & Prevention, 23, 23032310.

C. Hoekstra , G. Willemsen , C. E. van Beijsterveldt , C. B. Lambalk , G. W. Montgomery , & D. I. Boomsma (2010). Body composition, smoking, and spontaneous dizygotic twinning. Fertility and Sterility, 93, 885893.

C. Hoekstra , Z. Z. Zhao , C. B. Lambalk , G. Willemsen , N. G. Martin , D. I. Boomsma , . . . G. W. Montgomery (2008). Dizygotic twinning. Human Reproduction Update, 14, 3747.

Y. M. Hur , J. Kaprio , W. G. Iacono , D. I. Boomsma , M. McGue , K. Silventoinen , . . . K. Mitchell (2008). Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins. International Journal of Obesity, 32, 14551467.

I. Iachine , H. C. Petersen , & K. O. Kyvik (2010). Robust tests for the equality of variances for clustered data. Journal of Statistical Computation and Simulation, 80, 365377.

Y. Imaizumi (2005). Demographic trends in Japan and Asia. In I. Blickstein , L. G. Keith , & D. M. Keith (Eds.), Multiple pregnancy (2nd ed., pp. 3338). New York, NY: Taylor and Francis.

A. Jelenkovic , A. Ortega-Alonso , R. J. Rose , J. Kaprio , E. Rebato , & K. Silventoinen (2011). Genetic and environmental influences on growth from late childhood to adulthood: A longitudinal study of two Finnish twin cohorts. American Journal of Human Biology, 23, 764773.

S. Johansson , A. Iliadou , N. Bergvall , U. de Faire , M. S. Kramer , Y. Pawitan , . . . S. Cnattingius (2008). The association between low birth weight and type 2 diabetes: Contribution of genetic factors. Epidemiology, 19, 659665.

M. Johansson , & F. Rasmussen (2001). Birthweight and body mass index in young adulthood: The Swedish young male twins study. Twin Research, 4, 400405.

J. Kaprio , J. Tuomilehto , M. Koskenvuo , K. Romanov , A. Reunanen , J. Eriksson , . . . Y. A. Kesäniemi (1992). Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia, 35, 10601067.

H. R. Lajunen , J. Kaprio , A. Keski-Rahkonen , R. J. Rose , L. Pulkkinen , A. Rissanen , . . . K. Silventoinen (2009). Genetic and environmental effects on body mass index during adolescence: A prospective study among Finnish twins. International Journal of Obesity, 33, 559567.

M. M. Lash , & A. Armstrong (2009). Impact of obesity on women's health. Fertility and Sterility, 91, 17121716.

M. Lehtovirta , J. Kaprio , C. Forsblom , J. Eriksson , J. Tuomilehto , & L. Groop (2000). Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins. Diabetologia, 43, 285293.

M. Lehtovirta , K. H. Pietiläinen , E. Levalahti , K. Heikkila , L. Groop , K. Silventoinen , . . . J. Kaprio (2010). Evidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: A follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish twin cohort study. Diabetologia, 53, 13141321.

R. J. Loos , G. Beunen , R. Fagard , C. Derom , & R. Vlietinck (2001). The influence of zygosity and chorion type on fat distribution in young adult twins consequences for twin studies. Twin Research, 4, 356364.

V. Lummaa , E. Haukioja , R. Lemmetyinen , & M. Pikkola (1998). Natural selection on human twinning. Nature, 394, 533534.

A. Macfarlane , & B. Blondel (2005). Demographic trends in Western European countries. In I. Blickstein , L. G. Keith & D. M. Keith (Eds.), Multiple pregnancy (2nd ed., pp. 1121). New York, NY: Taylor and Francis.

L. McLaren (2007). Socio-economic status and obesity. Epidemiologic Reviews, 29, 2948.

S. Oberg , S. Cnattingius , S. Sandin , P. Lichtenstein , R. Morley , & A. N. Iliadou (2012). Twinship influence on morbidity and mortality across the lifespan. International Journal of Epidemiology, 41, 10021009.

I. Petersen , M. M. Nielsen , H. Beck-Nielsen , & K. Christensen (2011). No evidence of a higher 10-year period prevalence of diabetes among 77,885 twins compared with 215,264 singletons from the Danish birth cohorts, 1910–1989. Diabetologia, 54, 20162024.

K. H. Pietiläinen , J. Kaprio , A. Rissanen , T. Winter , A. Rimpelä , R. J. Viken , . . . R. J. Rose (1999). Distribution and heritability of BMI in Finnish adolescents aged 16 y and 17 y: A study of 4884 twins and 2509 singletons. International Journal of Obesity and Related Metabolic Disorders, 23, 107115.

K. H. Pietiläinen , J. Kaprio , M. Rasanen , T. Winter , A. Rissanen , & R. J. Rose (2001). Tracking of body size from birth to late adolescence: Contributions of birth length, birth weight, duration of gestation, parents’ body size, and twinship. American Journal of Epidemiology, 154, 2129.

P. Poulsen , & A. Vaag (2006). The intrauterine environment as reflected by birth size and twin and zygosity status influences insulin action and intracellular glucose metabolism in an age- or time-dependent manner. Diabetes, 55, 18191825.

C. H. Ramlau-Hansen , A. M. Thulstrup , E. A. Nohr , J. P. Bonde , T. I. Sørensen , & J. Olsen (2007). Sub-fecundity in overweight and obese couples. Human Reproduction, 22, 16341637.

U. M. Reddy , A. M. Branum , & M. A. Klebanoff (2005). Relationship of maternal body mass index and height to twinning. Obstetrics and Gynecology, 105, 593597.

K. Schousboe , G. Willemsen , K. O. Kyvik , J. Mortensen , D. I. Boomsma , B. K. Cornes , . . . J. R. Harris (2003). Sex differences in heritability of BMI: A comparative study of results from twin studies in eight countries. Twin Research, 6, 409421.

K. Silventoinen , P. K. Magnusson , P. Tynelius , J. Kaprio , & F. Rasmussen (2008a). Heritability of body size and muscle strength in young adulthood: A study of one million Swedish men. Genetic Epidemiology, 32, 341349.

K. Silventoinen , K. H. Pietiläinen , P. Tynelius , T. I. Sørensen , J. Kaprio , & F. Rasmussen (2007b). Genetic and environmental factors in relative weight from birth to age 18: The Swedish young male twins study. International Journal of Obesity, 31, 615621.

K. Silventoinen , K. H. Pietiläinen , P. Tynelius , T. I. Sørensen , J. Kaprio , & F. Rasmussen (2008b). Genetic regulation of growth from birth to 18 years of age: The Swedish young male twins study. American Journal of Human Biology, 20, 292298.

K. Silventoinen , S. Sammalisto , M. Perola , D.I. Boomsma , B. K. Cornes , C. Davis , . . . J. Kaprio (2003). Heritability of adult body height: A comparative study of twin cohorts in eight countries. Twin Research, 6, 399408.

J. Smits , & C. Monden (2011). Twinning across the developing world. PloS One, 6, e25239.

N. Y. Souren , A. D. Paulussen , R. J. Loos , M. Gielen , G. Beunen , R. Fagard , . . . M. P. Zeegers (2007). Anthropometry, carbohydrate and lipid metabolism in the East Flanders prospective twin survey: Heritabilities. Diabetologia, 50, 21072116.

A. J. Swerdlow , B. L. De Stavola , M. A. Swanwick , & N. E. Maconochie (1997). Risks of breast and testicular cancers in young adult twins in England and Wales: Evidence on prenatal and genetic aetiology. Lancet, 350, 17231728.

A. Tandberg , T. Bjorge , P. E. Bordahl , & R. Skjaerven (2007). Increasing twinning rates in Norway, 1967–2004: The influence of maternal age and assisted reproductive technology (ART). Acta Obstetricia et Gynecologica Scandinavica, 86, 833839.

S. Vitthala , T. A. Gelbaya , D. R. Brison , C. T. Fitzgerald , & L. G. Nardo (2009). The risk of monozygotic twins after assisted reproductive technology: A systematic review and meta-analysis. Human Reproduction Update, 15, 4555.

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Twin Research and Human Genetics
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