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Background illumination reduces horizontal cell receptive-field size in both normal and 6-hydroxydopamine-lesioned goldfish retinas

Published online by Cambridge University Press:  02 June 2009

William H. Baldridge  and
Alexander K. Ball
William H. Baldridge
Affiliation:
Division of Anatomy and Experimental Morphology, Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
Alexander K. Ball
Affiliation:
Division of Anatomy and Experimental Morphology, Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
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Abstract

The effect of background illumination on horizontal cell receptive-field size and dye coupling was investigated in isolated superfused goldfish retinas. Background illumination reduced both horizontal cell receptive-field size and dye coupling. The effect of light on horizontal cell receptive-field size was mimicked by treating the retina with 20 μM dopamine. To test the hypothesis that the effects of light were due to endogenous dopamine release, the effect of light was studied in goldfish retinas in which dopaminergic interplexiform cells were lesioned using 6-hydroxydopamine treatment. In lesioned retinas, background illumination reduced both horizontal cell receptive-field size and dye coupling. Furthermore, the effect of background illumination on unlesioned animals could not be blocked by prior treatment with the D1 dopamine receptor antagonist SCH-23390. These results suggest that, in goldfish retina, dopamine release is not the only mechanism by which horizontal cell receptive-field size could be reduced by light.

Keywords

Horizontal cellsGoldfishGap junctionsDopamine6-hydroxydopamine
Type
Research Articles
Information
Visual Neuroscience , Volume 7 , Issue 5 , November 1991 , pp. 441 - 450
Copyright
Copyright © Cambridge University Press 1991

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