Skip to main content

Basic visual capacities and shape discrimination after lesions of extrastriate area V4 in macaques

  • William H. Merigan (a1)

lbotenic acid lesions were made in four macaque monkeys in a region of cortical area V4 that corresponds to the lower quadrant of one hemifield. For visual testing, fixation locus was monitoredwith scleral search coils and controlled behaviorally to place test stimuli either in the lesionedquadrant or in a control location in the opposite hemifield. Some basic visual capacities were slightly altered by the lesions; there was a two-fold reduction of luminance contrast sensitivity as well as red-green chromatic contrast sensitivity, both tested with stationary gratings. On the other hand, little or no loss was found when contrast sensitivity for detection or direction discrimination was tested with 10–Hz drifting gratings nor was there a reliable change in visual acuity. Hue and luminance matching were tested with a spatially more complex matching-to-sample task, but monkeys could not learn this task in the visual field locus of a V4 lesion. If previously trained at this locus, performance was not affected by the lesion. In contrast to the small effects on basic visual capabilities, performance on two form discrimination tasks was devastated by V4 lesions. The first involved discriminating the orientation of colinear groups of dots on a background of randomly placed dots. The second involved discriminating the orientation of a group of three line segments surrounded by differently oriented line segments. Some selectivity of the deficitsfor form discrimination was shown by the lack of an effect of the lesions on a global motion discrimination. These results show that while V4 lesions cause only slight disruptions of basic visual capacities, they profoundly disrupt form discriminations.

Hide All
Baizer J.S., Ungerleider L.G. & Desimone R. (1991). Organization of visual inputs to the inferior temporal and posterior parietal cortex in monkeys. Journal of Neuroscience 11, 168190.
Boussaoud D., Desimone R. & Ungerleider L.G. (1991). Visual topography of area TEO in the macaque. Journal of Comparative Neurology 306, 554575.
Dean P. (1979). Visual cortex ablation and thresholds for successively presented stimuli in rhesus monkeys: Hue. Experimental Brain Research 35, 6983.
Desimone R., Li L., Lehky S., Ungerleider L.G. & Mishkin M. (1990). Effects of V4 lesions on visual discrimination performance and responses of neurons in inferior temporal cortex. Neuroscience Abstracts 16, 621.
Desimone R., Moran J., Schein S. & Mishkin M. (1993). A role for the corpus callosum in visual area V4 of the macaque. Visual Neuroscience 10, 159171.
DeYoe E.G. & Van Essen D.C. (1985). Segregation of efferent connections and receptive field properties in visual area V2 of the macaque. Nature 317, 5861.
Duffy C. & Wurtz R. (1991). Sensitivity of MST neurons to optic flow stimuli. 1. A continuum of response selectivity to large-field stimuli. Journal of Neurophysiology 65, 13291345.
Finney D.J. (1971). Probit Analysis. Cambridge, Massachusetts: Cambridge University Press.
Gallyas F. (1979). Silver staining of myelin by means of physical development. Neurology Research 1, 203209.
Gatass R., Sousa A.P.B. & Gross C.G. (1988). Visuotopic organization and extent of V3 and V4 of the macaque. Journal of Neuroscience 8, 18311845.
Gross C.G. (1973). Visual functions of inferotemporal cortex. In Handbook of Sensory Physiology, Vol 7/3b, Central Visual Information, ed. Jung R., pp. 451482. Berlin: Springer.
Gross C.G., Rocha-Miranda C.E. & Bender D. (1972). Visual properties of neurons in inferotemporal cortex of the macaque. Journal of Neurophysiology 35, 96111.
Haenny P.E., Maunsell J.H.R. & Schiller P.H. (1988). State dependent activity in monkey visual cortex: II Retinal and extraretinal factors in V4. Experimental Brain Research 69, 245259.
Heywood C.A. & Cowey A. (1987). On the role of cortical area V4 in the discrimination of hue and pattern in macaque monkeys. Journal of Neuroscience 7, 26012617.
Heywood C.A., Gadotti A. & Cowey A. (1992). Cortical area V4 and its role in the perception of color. Journal of Neuroscience 12, 40564065.
Judge S.J., Richmond B.J. & Chu F.C. (1980). Implantation of magnetic search coils for measurement of eye position: An improved method. Vision Research 20, 535538.
Krauskopf J., Williams D.R. & Heeley D.W. (1982). Cardinal directions of color space. Vision Research 22, 11231131.
Merigan W. (1989). Chromatic and achromatic vision of macaques: Role of the P pathway. Journal of Neuroscience 9, 776783.
Merigan W.H., Byrne C.E. & Maunsell J.H.R. (1991 a). Does primate motion perception depend on the magnocellular pathway? Journal of Neuroscience 11, 34223429.
Merigan W.H. & Katz L.M. (1990). Spatial resolution across the macaque retina. Vision Research 30, 985991.
Merigan W.H., Katz L.M. & Maunsell J.H.R. (1991 b). The effects of parvocellular lateral geniculate lesions on the acuity and contrast sensitivity of macaque monkeys. Journal of Neuroscience 11, 9941001.
Merigan W.H., Nealey T.A. & Maunsell J.H.R. (1993). Visual effects of lesions of cortical area V2 in macaques. Journal of Neuroscience 11, 9941001.
Moran J. & Desimone R. (1985). Selective attention gates visual processing in the extrastriate cortex. Science 229, 782784.
Pasternak T., Horn K.M. & Maunsell J.H.R. (1989). Deficits in speed discrimination following lesions of the lateral suprasylvian cortex in the cat. Visual Neuroscience 3, 365375.
Pasternak T. & Merigan W.H. (1994). Motion perception following lesions of the superior temporal sulcus in the monkey. Cerebral Cortex 4, 247259.
Pelli D.G. (1985). Uncertainty explains many aspects of visual contrast detection and discrimination. Journal of the Optical Society of America A2, 15081532.
Schiller P. (1993). The effects of V4 and middle temporal (MT) area lesions on visual performance in the rhesus monkey. Visual Neuroscience 10, 717746.
Schiller P. & Lee K. (1991). The role of the primate extrastriate area V4 in vision. Science 251, 12511253.
Sclar G., Maunsell J.H.R. & Lennie P. (1990). Coding of image contrast in the central visual pathways of the macaque monkey. Vision Research 30, 110.
Shipp S. & Zeki S. (1985). Segregation of pathways leading from area V2 to areas V4 and V5 of macaque monkey visual cortex. Nature 315, 322325.
Van Essen D.C. & Maunsell J.H.R. (1980). Two-dimensional maps of the cerebral cortex. Journal of Comparative Neurology 191, 255281.
Victor J.D., Maiese K., Shapley R., Sidtis J. & Gazzaniga M.S. (1989). Acquired central dyschromatopsia: Analysis of a case with preservation of color discrimination. Clinical Visual Science 4, 183196.
Walsh V., Butler S.R., Carden D. & Kulikowski J.J. (1992). The effects of V4 lesions on visual abilities of macaques: Shape discrimination. Behavioral Brain Research 50, 115126.
Watson A.B. (1990). Gain, noise, and contrast sensitivity of linear visual neurons. Visual Neuroscience 4, 147157.
Williams D.R. (1985). Aliasing in human foveal vision. Vision Research 25, 195205.
Wong-Riley M. (1979). Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. Brain Research 171, 1128.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Visual Neuroscience
  • ISSN: 0952-5238
  • EISSN: 1469-8714
  • URL: /core/journals/visual-neuroscience
Please enter your name
Please enter a valid email address
Who would you like to send this to? *



Full text views

Total number of HTML views: 0
Total number of PDF views: 14 *
Loading metrics...

Abstract views

Total abstract views: 172 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 23rd November 2017. This data will be updated every 24 hours.