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Functional localization of the nitric oxide/cGMP pathway in the salamander retina

  • JAN J. BLOM (a1), TODD A. BLUTE (a1) and WILLIAM D. ELDRED (a1)
  • DOI: http://dx.doi.org/10.1017/S0952523809990125
  • Published online: 01 May 2009
Abstract
Abstract

Nitric oxide (NO) is a gaseous neuromodulator that has physiological functions in every cell type in the retina. Evidence indicates that NO often plays a role in the processing of visual information in the retina through the second messenger cyclic guanosine monophosphate (cGMP). Despite numerous structural and functional studies of this signaling pathway in the retina, none have examined many of the elements of this pathway within a single study in a single species. In this study, the NO/cGMP pathway was localized to specific regions and cell types within the inner and outer retina. We have immunocytochemically localized nitric oxide synthase, the enzyme that produces NO, in photoreceptor ellipsoids, four distinct classes of amacrine cells, Müller and bipolar cells, somata in the ganglion cell layer, as well as in processes within both plexiform layers. Additionally, we localized NO production in specific cell types using the NO-sensitive dye diaminofluorescein. cGMP immunocytochemistry was used to functionally localize soluble guanylate cyclase that was activated by an NO donor in select amacrine and bipolar cell classes. Analysis of cGMP and its downstream target, cGMP-dependent protein kinase II (PKGII), showed colocalization within processes in the outer retina as well as in somata in the inner retina. The results of this study showed that the NO/cGMP signaling pathway was functional and its components were widely distributed throughout specific cell types in the outer and inner salamander retina.

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Corresponding author
*Address correspondence and reprint requests to: William D. Eldred, Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215. E-mail: eldred@bu.edu
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

I. Ahmad , T. Leinders-Zufall , J.D. Kocsis , G.M. Shepherd , F. Zufall & C.J. Barnstable (1994). Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron 12, 155165.

T.A. Blute , H.K. Lee , T. Huffmaster , S. Haverkamp & W.D. Eldred (2000 a). Localization of natriuretic peptides and their activation of particulate guanylate cyclase and nitric oxide synthase in the retina. Journal of Comparative Neurology 424, 689700.

T.A. Blute , P. Velasco & W.D. Eldred (1998). Functional localization of soluble guanylate cyclase in turtle retina: Modulation of cGMP by nitric oxide donors. Visual Neuroscience 15, 485498.

B.A. Cimini , C.E. Strang , V.E. Wotring , K.T. Keyser & W.D. Eldred (2008). Role of acetylcholine in nitric oxide production in the salamander retina. Journal of Comparative Neurology 507, 19521963.

J. de Vente , H.W. Steinbusch & J. Schipper (1987). A new approach to immunocytochemistry of 3′,5′-cyclic guanosine monophosphate: Preparation, specificity, and initial application of a new antiserum against formaldehyde-fixed 3′,5′-cyclic guanosine monophosphate. Neuroscience 22, 361373.

S.H. De Vries & E.A. Schwartz (1989). Modulation of an electrical synapse between solitary pairs of catfish horizontal cells by dopamine and second messengers. The Journal of Physiology 414, 351375.

W.D. Eldred & T.A. Blute (2005). Imaging of nitric oxide in the retina. Vision Research 45, 34693486.

I.M. Goldstein , P. Ostwald & S. Roth (1996). Nitric oxide: A review of its role in retinal function and disease. Vision Research 36, 29792994.

C. Griffiths & J. Garthwaite (2001). The shaping of nitric oxide signals by a cellular sink. The Journal of Physiology 536, 855862.

F. Hofmann , R. Feil , T. Kleppisch & J. Schlossmann (2006). Function of cGMP-dependent protein kinases as revealed by gene deletion. Physiological Reviews 86, 123.

N. Hogg (2002). The biochemistry and physiology of S-nitrosothiols. Annual Review of Pharmacology and Toxicology 42, 585600.

D.E. Kurenni , G.A. Thurlow , R.W. Turner , L.L. Moroz , K.A. Sharkey & S. Barnes (1995). Nitric oxide synthase in tiger salamander retina. Journal of Comparative Neurology 361, 525536.

D.E. Kurenny , L.L. Moroz , R.W. Turner , K.A. Sharkey & S. Barnes (1994). Modulation of ion channels in rod photoreceptors by nitric oxide. Neuron 13, 315324.

S. Kusaka , I. Dabin , C.J. Barnstable & D.G. Puro (1996). cGMP-mediated effects on the physiology of bovine and human retinal Muller (glial) cells. The Journal of Physiology 497(Pt 3), 813824.

C. Lu & D.G. McMahon (1997). Modulation of hybrid bass retinal gap junctional channel gating by nitric oxide. The Journal of Physiology 499(Pt 3), 689699.

B.R. Maple , J. Zhang , J.J. Pang , F. Gao & S.M. Wu (2005). Characterization of displaced bipolar cells in the tiger salamander retina. Vision Research 45, 697705.

E. Miyachi , M. Murakami & T. Nakaki (1990). Arginine blocks gap junctions between retinal horizontal cells. Neuroreport 1, 107110.

S. Nawy & C.E. Jahr (1991). cGMP-gated conductance in retinal bipolar cells is suppressed by the photoreceptor transmitter. Neuron 7, 677683.

J.J. Pang , F. Gao & S.M. Wu (2004). Stratum-by-stratum projection of light response attributes by retinal bipolar cells of Ambystoma. The Journal of Physiology 558, 249262.

D.V. Pow & D.K. Crook (1995). Immunocytochemical evidence for the presence of high levels of reduced glutathione in radial glial cells and horizontal cells in the rabbit retina. Neuroscience Letters 193, 2528.

R. Shiells & G. Falk (1992). Retinal on-bipolar cells contain a nitric oxide-sensitive guanylate cyclase. Neuroreport 3, 845848.

R.J. Singh , N. Hogg , J. Joseph & B. Kalyanaraman (1996). Mechanism of nitric oxide release from S-nitrosothiols. The Journal of Biological Chemistry 271, 1859618603.

A. Sitaramayya (2002). Soluble guanylate cyclases in the retina. Molecular and Cellular Biochemistry 230, 177186.

G.R. Upchurch Jr, G.N. Welch & J. Loscalzo (1995). S-nitrosothiols: Chemistry, biochemistry, and biological actions. Advances in Pharmacology 34, 343349.

J. Wood & J. Garthwaite (1994). Models of the diffusional spread of nitric oxide: Implications for neural nitric oxide signalling and its pharmacological properties. Neuropharmacology 33, 12351244.

D. Yu & W.D. Eldred (2005 b). Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina. Journal of Comparative Neurology 483, 278291.

A. Zai , M.A. Rudd , A.W. Scribner & J. Loscalzo (1999). Cell-surface protein disulfide isomerase catalyzes transnitrosation and regulates intracellular transfer of nitric oxide. Journal of Clinical Investigation 103, 393399.

N. Zhang , A. Beuve & E. Townes-Anderson (2005). The nitric oxide-cGMP signaling pathway differentially regulates presynaptic structural plasticity in cone and rod cells. The Journal of Neuroscience 25, 27612770.

X. Zhang & R.H. Cote (2005). cGMP signaling in vertebrate retinal photoreceptor cells. Frontiers in Bioscience 10, 11911204.

T.A. Blute , M.R. Lee & W.D. Eldred (2000 b). Direct imaging of NMDA-stimulated nitric oxide production in the retina. Visual Neuroscience 17, 557566.

W.D. Eldred (2000). Nitric oxide in the retina. Functional neuroanatomy of the nitric oxide system. In Handbook of Chemical Neuroanatomy Vol. 17, ed. H.W.M. Steinbusch , J. De Vente & S.R. Vincent , pp. 111145. New York: Elsevier.

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Visual Neuroscience
  • ISSN: 0952-5238
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