Skip to main content
×
Home
    • Aa
    • Aa

Irreversible color vision losses in patients with chronic mercury vapor intoxication

  • CLÁUDIA FEITOSA-SANTANA (a1) (a2), MIRELLA T.S. BARBONI (a1) (a2), NESTOR N. OIWA (a1) (a2), GALINA V. PARAMEI (a3), ANA LUISA A.C. SIMÕES (a2), MARCELO F. DA COSTA (a1) (a2), LUIZ CARLOS L. SILVEIRA (a4) (a5) and DORA F. VENTURA (a1) (a2)...
Abstract

This longitudinal study addresses the reversibility of color vision losses in subjects who had been occupationally exposed to mercury vapor. Color discrimination was assessed in 20 Hg-exposed patients (mean age = 42.4 ± 6.5 years; 6 females and 14 males) with exposure to Hg vapor during 10.5 ± 5.3 years and away from the work place (relative to 2002) for 6.8 ± 4.2 years. During the Hg exposure or up to one year after ceasing it, mean urinary Hg concentration was 47 ± 35.4 μg/g creatinine. There was no information on Hg urinary concentration at the time of the first tests, in 2002 (Ventura et al., 2005), but at the time of the follow-up tests, in 2005, this value was 1.4 ± 1.4 μg/g creatinine for patients compared with 0.5 ± 0.5 μg/g creatinine for controls (different group from the one in Ventura et al. (2005)). Color vision was monocularly assessed using the Cambridge Colour Test (CCT). Hg-exposed patients had significantly worse color discrimination (p < 0.02) than controls, as evaluated by the size of MacAdam's color discrimination ellipses and color discrimination thresholds along protan, deutan, and tritan confusion axes. There were no significant differences between the results of the study in Ventura et al. (2005) and in the present follow-up measurements, in 2005, except for worsening of the tritan thresholds in the best eye in 2005. Both chromatic systems, blue-yellow and red-green, were affected in the first evaluation (Ventura et al., 2005) and remained impaired in the follow-up testing, in 2005. These findings indicate that following a long-term occupational exposure to Hg vapor, even several years away from the source of intoxication, color vision impairment remains irreversible.

Copyright
Corresponding author
Address correspondence and reprint requests to: Cláudia Feitosa-Santana, Av. Prof. Mello Moraes, 1721, Bloco A, Sala D9, 05508-900 São Paulo, Brazil. E-mail: claudia@feitosa-santana.com
References
Hide All
M.T.S. Barboni , M.F. Costa , A.L.A. Moura , C. Feitosa-Santana , M. Gualtieri , M. Lago , M.A. Medrado-Faria , L.C.L. Silveira & D.F. Ventura (2008). Visual field losses in workers exposed to mercury vapor. Environmental Research 107, 124131.

L.H.M. Canto-Pereira , M. Lago , M.F. Costa , A.R. Rodrigues , C.A. Saito , L.C.L. Silveira & D.F. Ventura (2005). Visual impairment on dentists related to occupational mercury exposure. Environmental Toxicology and Pharmacology 19, 517522.

A. Cavalleri , L. Belotti , F. Gobba , G. Luzzana , P. Rosa & P. Seghizzi (1995). Colour vision loss in workers exposed to elemental mercury vapour. Toxicology Letters 77, 351356.

A. Cavalleri & F. Gobba (1998). Reversible color vision loss in occupational exposure to metallic mercury. Environmental Research 77, 173177.

C. Feitosa-Santana , M.F. Costa , M. Lago & D.F. Ventura (2007). Long-term loss of color vision after exposure to mercury vapor. Brazilian Journal of Medical and Biological Research 40, 409414.

W.M. Hart (1987). Acquired dyscromatopsias. Survey of Ophthalmology 32, 1031.

G.V. Paramei , M. Meyer-Baron & A. Seeber (2004). Impairments of colour vision induced by organic solvents: A meta-analysis study. NeuroToxicology 25, 803816.

B.C. Regan , N. Freudenthaler , R. Kolle , J.D. Mollon & W. Paulus (1998). Colour discrimination thresholds in Parkinson's disease: Results obtained with a rapid computer-controlled colour vision test. Vision Research 38, 34273431.

A.R. Rodrigues , C.R. Botelho de Souza , A.M. Braga , P.S.S. Rodrigues , A.T. Silveira , E.T.B. Damin , M.I.T. Côrtes , A.J.O. Castro , G.A. Mello , J.L.F. Vieira , M.C.N. Pinheiro , D.F. Ventura & L.C.L. Silveira (2007). Mercury toxicity: Contrast sensitivity and color discrimination of subjects exposed to mercury. Brazilian Journal of Medical and Biological Research 40, 415424.

L.C.L. Silveira , E.T.B. Damin , M.C.N. Pinheiro , A.R. Rodrigues , A.L.A. Moura , M.I.T. Côrtes & G.A. Mello (2003). Visual dysfunction following mercury exposure by breathing mercury vapour or by eating mercury-contaminated food. In Normal and Defective Colour Vision, eds. J.D. Mollon , J. Pokorny & K. Knoblauch , pp. 409417. Oxford: Oxford University Press.

P. Urban , F. Gobba , J. Nerudova , E. Lukas , Z. Cabelkova & M. Cikrt (2003). Color discrimination impairment in workers exposed to mercury vapor. NeuroToxicology 24, 711716.

D.F. Ventura , L.C. Silveira , A.R. Rodrigues , J. de Souza , M. Gualtieri , D.M. Bonci & M.F. Costa (2003). Preliminary norms for the Cambridge Colour Test. In Normal and Defective Colour Vision, eds. J.D. Mollon , J. Pokorny & K. Knoblauch , pp. 331339. Oxford: Oxford University Press.

D.F. Ventura , A.L. Simoes , S. Tomaz , M.F. Costa , M. Lago , M.T.V. Costa , L.H.M. Canto-Pereira , J.M. de Souza , M.A.M. Faria & L.C.L. Silveira (2005). Colour vision and contrast sensitivity losses of mercury intoxicated industry workers in Brazil. Environmental Toxicology and Pharmacology 19, 523529.

K. Warfvinge & A. Bruun (1996). Mercury accumulation in the Squirrel monkey eye after mercury vapour exposure. Toxicology 107, 189200.

K. Warfvinge & A. Bruun (2000). Mercury distribution in the squirrel monkey retina after in utero exposure to mercury vapor. Environmental Research 83, 102109.

E.C. Zachi , D.F. Ventura , M.A.M. Faria & A. Taub (2007). Neuropsychological dysfunction related to earlier occupational exposure to mercury vapor. Brazilian Journal of Medical and Biological Research 40, 425433.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Visual Neuroscience
  • ISSN: 0952-5238
  • EISSN: 1469-8714
  • URL: /core/journals/visual-neuroscience
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 3
Total number of PDF views: 19 *
Loading metrics...

Abstract views

Total abstract views: 178 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 18th October 2017. This data will be updated every 24 hours.