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Lagged cells in alert monkey lateral geniculate nucleus

  • ALAN B. SAUL (a1)
Abstract
Abstract

Five lagged cells were recognized by extracellular recording in the lateral geniculate nucleus of an awake, behaving macaque monkey. Previous reports of lagged cells were all in the anesthetized cat. Both parvocellular and magnocellular lagged cells were observed. Response timing was distributed continuously across the population, and both sustained and transient responses were seen in the magnocellular subpopulation. Cortex thus receives signals with a wide range of timing, which can mediate direction selectivity across multiple dimensions.

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Corresponding author
*Address correspondence and reprint requests to: Alan B. Saul, Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912. E-mail: asaul@mcg.edu
References
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Adelson E.H. & Bergen J.R. (1985). Spatiotemporal energy models for the perception of motion. Journal of the Optical Society of America A 2, 284299.
Ahmad A. & Spear P.D. (1993). Effects of aging on the size, density, and number of rhesus monkey lateral geniculate neurons. Journal of Comparative Neurology 334, 631643.
Alonso J.-M., Usrey W.M. & Reid R.C. (2001). Rules of connectivity between geniculate cells and simple cells in cat primary visual cortex. Journal of Neuroscience 21, 40024015.
Augustinaite S. & Heggelund P. (2007). Changes in firing pattern of lateral geniculate neurons caused by membrane potential dependent modulation of retinal input through NMDA receptors. Journal of Physiology 582, 297315.
Balercia G., Kultas-Ilinsky K., Bentivoglio M. & Ilinksy I.A. (1996). Neuronal and synaptic organization of the centromedian nucleus of the monkey thalamus: a quantitative ultrastructural study, with tract tracing and immunohistochemical observations. Journal of Neurocytology 25, 267288.
Blakemore C. & Vital-Durand F. (1986). Organization and post-natal development of the monkey’s lateral geniculate nucleus. Journal of Physiology 380, 453491.
Blitz D.M. & Regehr W.G. (2005). Timing and specificity of feed-forward inhibition within the LGN. Neuron 45, 917928.
Cai D., DeAngelis G.C. & Freeman R.D. (1997). Spatiotemporal receptive field organization in the lateral geniculate nucleus of cats and kittens. Journal of Neurophysiology 78, 10451061.
Conway B.R. (2001). Spatial structure of cone inputs to color cells in alert macaque primary visual cortex (V1). Journal of Neuroscience 21, 27682783.
Dacey D.M & Lee B.B. (1994). The ‘blue-on’ opponent pathway in primate retina originates from a distinct bistratified ganglion cell type. Nature 367, 731735.
DeValois R.L., Cottaris N.P., Mahon L.E., Elfar S.D. & Wilson J.A. (2000). Spatial and temporal receptive fields of geniculate and cortical cells and directional selectivity. Vision Research 40, 36853702.
Dreher B., Fukada Y. & Rodieck R.W. (1976). Identification, classification and anatomical segregation of cells with X-like and Y-like properties in the lateral geniculate nucleus of old-world primates. Journal of Physiology 258, 433452.
Famiglietti E.V. & Peters A. (1972). The synaptic glomerulus and the intrinsic neuron in the dorsal lateral geniculate nucleus of the cat. Journal of Comparative Neurology 144, 285334.
Ferrera V.P., Nealey T.A. & Maunsell J.H.R. (1994). Responses in macaque visual area V4 following inactivation of the parvocellular and magnocellular LGN pathways. Journal of Neuroscience 14, 20802088.
Gegenfurtner K.R. & Hawken M.J. (1995). Temporal and chromatic properties of motion mechanisms. Vision Research 35, 15471563.
Gonzalez T. (1985). Clustering to minimize the maximum intercluster distance. Theoretical Computer Science 38, 293306.
Guillery R.W. (1966). A study of Golgi preparations from the dorsal lateral geniculate nucleus of the adult cat. Journal of Comparative Neurology 128, 2150.
Gur M. & Snodderly D.M. (1987). Studying striate cortex neurons in behaving monkeys: Benefits of image stabilization. Vision Research 27, 20812087.
Gur M. & Snodderly D.M. (2007). Direction selectivity in V1 of alert monkeys: Evidence for parallel pathways for motion processing. Journal of Physiology 585, 383400.
Hamori J., Pasik P. & Pasik T. (1983). Differential frequency of P-cells and I-cells in magnocellular and parvocellular laminae of monkey lateral geniculate nucleus. An ultrastructural study. Experimental Brain Research 52, 5766.
Hamori J., Pasik P. & Pasik T. (1991). Different types of synaptic triads in the monkey dorsal lateral geniculate nucleus. Journal für Hirnforschung 32, 369379.
Hartveit E. (1992). Simultaneous recording of lagged and nonlagged cells in the cat dorsal lateral geniculate nucleus. Experimental Brain Research 88, 229232.
Hartveit E. & Heggelund P. (1990). Neurotransmitter receptors mediating excitatory input to cells in the cat lateral geniculate nucleus. II. Non-lagged cells. Journal of Neurophysiology 63, 13611372.
Hartveit E. & Heggelund P. (1992). The effect of contrast on the visual response of lagged and nonlagged cells in the cat lateral geniculate nucleus. Visual Neuroscience 9, 515525.
Hartveit E. & Heggelund P. (1993). Brain-stem influence on visual response of lagged and nonlagged cells in the cat lateral geniculate nucleus. Visual Neuroscience 10, 325339.
Hawken M.J., Shapley R.M. & Grosof D.H. (1996). Temporal-frequency selectivity in monkey visual cortex. Visual Neuroscience 13, 477492.
Heggelund P. & Hartveit E. (1990). Neurotransmitter receptors mediating excitatory input to cells in the cat lateral geniculate nucleus. I. Lagged cells. Journal of Neurophysiology 63, 13471360.
Hendry S.H.C. & Reid R.C. (2000). The koniocellular pathway in primate vision. Annual Review of Neuroscience 23, 127153.
Horwitz G.D., Chichilnisky E.J. & Albright T.D. (2005). Blue-yellow signals are enhanced by spatiotemporal luminance contrast in macaque V1. Journal of Neurophysiology 93, 22632278.
Humphrey A.L. & Murthy A. (1999). Cell types and response timings in the medial interlaminar nucleus and C-layers of the cat lateral geniculate nucleus. Visual Neuroscience 16, 513525.
Humphrey A.L. & Saul A.B. (1992). Action of brainstem reticular afferents on lagged and nonlagged cells in the lateral geniculate nucleus. Journal of Neurophysiology 68, 673691.
Humphrey A.L. & Weller R.E. (1988 a). Functionally distinct groups of X-cells in the lateral geniculate nucleus of the cat. Journal of Comparative Neurology 268, 429447.
Humphrey A.L. & Weller R.E. (1988 b). Structural correlates of functionally distinct X-cells in the lateral geniculate nucleus of the cat. Journal of Comparative Neurology 268, 448468.
Kaplan E. & Shapley R.M. (1982). X and Y cells in the lateral geniculate nucleus of macaque monkeys. Journal of Physiology 330, 125143.
Kultas-Ilinsky K., Ribak C.E., Peterson G.M. & Oertel W.H. (1985). A description of the GABAergic neurons and axon terminals in the motor nuclei of the cat thalamus. Journal of Neuroscience 5, 13461369.
Kuroda M., Sugiura T., Shinkai M., Murakami K., Oda S. & Kishi K. (1993). Synaptic organization and prefrontal corticothalamic termination in the mediodorsal thalamic nucleus of the cat. Journal für Hirnforschung 34, 417430.
Kwon Y.H, Esguerra M. & Sur M. (1991). NMDA and non-NMDA receptors mediate visual responses of neurons in the cat’s lateral geniculate nucleus. Journal of Neurophysiology 66, 414428.
Kwon Y.H., Nelson S.B., Toth L.J. & Sur M. (1992). Effect of stimulus contrast and size on NMDA receptor activity in cat lateral geniculate nucleus. Journal of Neurophysiology 68, 182196.
Levitt J.B., Schumer R.A., Sherman S.M., Spear P.D. & Movshon J.A. (2001). Visual response properties of neurons in the LGN of normally reared and visually deprived macaque monkeys. Journal of Neurophysiology 85, 21112129.
Liu S. & Wong-Riley M. (1990). Quantitative light- and electron-microscopic analysis of cytochrome-oxidase distribution in neurons of the lateral geniculate nucleus of the adult monkey. Visual Neuroscience 4, 269287.
Livingstone M.S. & Hubel D. (1988). Segregation of form, color, movement, and depth: Anatomy, physiology, and perception. Science 240, 740749.
Lu S.M., Guido W., Vaughan J.W. & Sherman S.M. (1995). Latency variability of responses to visual stimuli in cells of the cat’s lateral geniculate nucleus. Experimental Brain Research 105, 717.
Malpeli J.G. & Baker F.H. (1975). The representation of the visual field in the lateral geniculate nucleus of Macaca mulatta. Journal of Comparative Neurology 161, 569594.
Malpeli J.G., Schiller P.H. & Colby C.L. (1981). Response properties of single cells in monkey striate cortex during reversible inactivation of individual lateral geniculate laminae. Journal of Neurophysiology 46, 11021119.
Marrocco R.T. (1976). Sustained and transient cells in monkey lateral geniculate nucleus: Conduction velocities and response properties. Journal of Neurophysiology 39, 340353.
Martin P.R., White A.J.R., Goodchild A.K., Wilder H.D. & Sefton A.E. (1997). Evidence that blue-ON cells are part of the third geniculocortical pathway in primates. European Journal of Neuroscience 9, 15361541.
Mastronarde D.N. (1987 a). Two classes of single-input X-cells in cat lateral geniculate nucleus. I. Receptive field properties and classification of cells. Journal of Neurophysiology 57, 357380.
Mastronarde D.N. (1987 b). Two classes of single-input X-cells in cat lateral geniculate nucleus. II. Retinal inputs and the generation of receptive field properties. Journal of Neurophysiology 57, 381413.
Mastronarde D.N. (1992). Nonlagged relay cells and interneurons in the cat lateral geniculate nucleus: receptive-field properties and retinal inputs. Visual Neuroscience 8, 407441.
Mastronarde D.N., Humphrey A.L. & Saul A.B. (1991). Lagged Y cells in the cat lateral geniculate nucleus. Visual Neuroscience 7, 191200.
Merigan W.H., Byrne C.E. & Maunsell J.H.R. (1991). Does primate motion perception depend on the magnocellular pathway? Journal of Neuroscience 11, 34223429.
Minnery B.S., Bruno R.M. & Simons D.J. (2003). Response transformation and receptive-field synthesis in the lemniscal trigeminothalamic circuit. Journal of Neurophysiology 90, 15561570.
Montero V.M. & Zempel J. (1986). The proportion and size of GABA-immunoreactive neurons in the magnocellular and parvocellular layers of the lateral geniculate nucleus of the rhesus monkey. Experimental Brain Research 62, 215223.
Mullen K.T. & Baker C.L. Jr. (1985). A motion aftereffect from an isoluminant stimulus. Vision Research 25, 685688.
Mullen K.T., Yoshizawa T. & Baker C.L. Jr. (2003). Luminance mechanisms mediate the motion of red-green isoluminant gratings: The role of “temporal chromatic aberration”. Vision Research 43, 12351247.
Norden J.J. & Kaas J.H. (1978). The identification of relay neurons in the dorsal lateral geniculate nucleus of monkeys using horseradish peroxidase. Journal of Comparative Neurology 182, 707725.
O’Keefe L.P., Levitt J.B., Kiper D.C., Shapley R.M. & Movshon J.A. (1998). Functional organization of owl monkey lateral geniculate nucleus and visual cortex. Journal of Neurophysiology 80, 594609.
Ralston H.J. III & Ralston D.D. (1994). Medial lemniscal and spinal projections to the macaque thalamus: an electron microscopic study of differing GABAergic circuitry serving thalamic somatosensory mechanisms. Journal of Neuroscience 14, 24852502.
Reichardt W. (1959). Autocorrelation and the central nervous system. In Sensory Communication, ed. Rosenblith A., pp. 303318. Cambridge, MA: MIT Press.
Reid R.C. & Shapley R.M. (2002). Space and time maps of cone photoreceptor signals in macaque lateral geniculate nucleus. Journal of Neuroscience 22, 61586175.
Reid R.C., Victor J.D. & Shapley R.M. (1992). Broadband temporal stimuli decrease the integration time of neurons in cat striate cortex. Visual Neuroscience 9, 3945.
Reitboeck H.J. (1983). Fiber microelectrodes for electrophysiological recordings. Journal of Neuroscience Methods 8, 249252.
Ruppertsberg A.I., Wuerger S.M. & Bertamini M. (2003). The chromatic input to global motion perception. Visual Neuroscience 20, 421428.
Sato F., Nakamura Y. & Shinoda Y. (1996). Three-dimensional analysis of cerebellar terminals and their postsynaptic components in the ventral lateral nucleus of the cat thalamus. Journal of Comparative Neurology 371, 537551.
Saul A.B. (2008 a). Lagged cells. Neurosignals 16, 209225.
Saul A.B. (2008 b). Temporal receptive field estimation using wavelets. Journal of Neuroscience Methods 168, 450464.
Saul A.B., Carras P.D. & Humphrey A.L. (2005). Temporal properties of inputs to direction selective neurons in monkey V1. Journal of Neurophysiology 94, 282294.
Saul A.B. & Feidler J.C. (2002). Development of response timing and direction selectivity in cat visual thalamus and cortex. Journal of Neuroscience 22, 29452955.
Saul A.B. & Humphrey A.L. (1990). Spatial and temporal response properties of lagged and non-lagged cells in the cat lateral geniculate nucleus. Journal of Neurophysiology 64, 206224.
Saul A.B. & Humphrey A.L. (1992 a). Evidence of input from lagged cells in the lateral geniculate nucleus to simple cells in cortical area 17 of the cat. Journal of Neurophysiology 68, 11901207.
Saul A.B. & Humphrey A.L. (1992 b). Temporal frequency tuning of direction selectivity in cat visual cortex. Visual Neuroscience 8, 365372.
Schein S.J. & deMonasterio F.M. (1987). Mapping of retinal and geniculate neurons onto striate cortex of macaque. Journal of Neuroscience 7, 9961009.
Schiller P.H., Logothetis N.K. & Charles E.R. (1990). Functions of the colour-opponent and broad-band channels of the visual system. Nature 343, 6870.
Schiller P.H. & Malpeli J.G. (1978). Functional specificity of lateral geniculate nucleus laminae of the rhesus monkey. Journal of Neurophysiology 41, 788797.
Sherman S.M., Wilson J.R., Kaas J.H. & Webb S.V. (1976). X- and Y-cells in the dorsal lateral geniculate nucleus of the owl monkey (Aotus trivirgatus). Science 192, 475477.
Snodderly D.M. & Gur M. (1995). Organization of striate cortex (V1) of alert, trained monkeys (Macaca fascicularis): Ongoing activity, stimulus selectivity, and widths of receptive field activating regions. Journal of Neurophysiology 74, 21002125.
Spear P.D., Moore R.J., Kim C.B., Xue J.T. & Tumosa N. (1994). Effects of aging on the primate visual system: Spatial and temporal processing by lateral geniculate neurons in young adult and old rhesus monkeys. Journal of Neurophysiology 72, 402420.
Steriade M., Paré D., Hu B. & Deschenes M. (1990). The visual thalamocortical system and its modulation by the brain stem core. In Progress in Sensory Physiology, Vol. 10, ed. Ottoson D. Berlin, Germany: Springer-Verlag.
Stockman A. & Sharpe L.T. (2000). The spectral sensitivities of the middle- and long-wavelength cones derived from measurements in observers of known genotype. Vision Research 40, 17111737.
Stone J. (1973). Sampling properties of microelectrodes assessed in the cat's retina. Journal of Neurophysiology, 36, 10711079.
Szmajda B.A., Buzás P., Fitzgibbon T. & Martin P.R. (2006). Geniculocortical relay of blue-off signals in the primate visual system. Proceedings of the National Academy of Science United States of America 103, 1951219517.
Tang Y., Saul A.B., Gur M., Goei S., Wong E., Ersoy B. & Snodderly D.M. (2007). Eye position compensation improves estimates of response magnitude and receptive field geometry in alert monkeys. Journal of Neurophysiology 97, 34393448.
Towe A.L. & Harding G.W. (1970). Extracellular microelectrode sampling bias. Experimental Neurology 29, 366381.
van Santen J.P.H. & Sperling G. (1985). Elaborated Reichardt detectors. Journal of the Optical Society of America A 2, 300321.
Wang C., Dreher B. & Burke W. (1994). Non-dominant suppression in the lateral geniculate nucleus of the cat: Laminar differences and class specificity. Experimental Brain Research 97, 451465.
Wang C., Dreher B. & Burke W. (1996). Effects of eliminating retinal Y cell input on center-surround interactions in the dorsal lateral geniculate nucleus of the cat. Visual Neuroscience 13, 10891097.
Watson A.B. & Ahumada A.J. Jr. (1985). Model of human visual-motion sensing. Journal of the Optical Society of America A 2, 322342.
Weber A.J., Chen H., Hubbard W.C. & Kaufman P.L. (2000). Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus. Investigative Ophthalmology and Visual Science 41, 13701379.
Wilson J.R. (1989). Synaptic organization of individual neurons in the macaque lateral geniculate nucleus. Journal of Neuroscience 9, 29313953.
Winer J.A., Miller L.M., Lee C.C. & Schreiner C.E. (2005). Auditory thalamocortical transformation: Structure and function. Trends in Neuroscience 28, 255263.
Winfield D.A. (1980). The synaptic organization of glomeruli in the magnocellular and parvocellular laminae of the lateral geniculate nucleus in the monkey. Brain Research 198, 5562.
Wolfe J. & Palmer L.A. (1998). Temporal diversity in the lateral geniculate nucleus of cat. Visual Neuroscience 15, 653675.
Xu X., Ichida J.M., Allison J.D., Boyd J.D. & Bonds A.B. (2001). A comparison of koniocellular, magnocellular and parvocellular receptive field properties in the lateral geniculate nucleus of the owl monkey (Aotus trivirgatus). Journal of Physiology 531, 203218.
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Visual Neuroscience
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