Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 17
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Cheng, Z.-Y. Wang, X.-P. Schmid, K.L. and Han, X.-G. 2014. GABAB1 and GABAB2 receptor subunits co-expressed in cultured human RPE cells regulate intracellular Ca2+ via Gi/o-protein and phospholipase C pathways. Neuroscience, Vol. 280, p. 254.

    Palacios-Muñoz, Angelina Escobar, Maria J. Vielma, Alex Araya, Joaquín Astudillo, Aland Valdivia, Gonzalo García, Isaac E. Hurtado, José Schmachtenberg, Oliver Martínez, Agustín D. and Palacios, Adrian G. 2014. Role of connexin channels in the retinal light response of a diurnal rodent. Frontiers in Cellular Neuroscience, Vol. 8,

    Popova, E. 2014. Ionotropic GABA Receptors and Distal Retinal ON and OFF Responses. Scientifica, Vol. 2014, p. 1.

    Dang, Trung M. Vingrys, Algis J. and Bui, Bang V. 2013. Sustained and Transient Contributions to the Rat Dark-Adapted Electroretinogram b-Wave. Journal of Ophthalmology, Vol. 2013, p. 1.

    Smith, Benjamin J. Tremblay, François and Côté, Patrice D. 2013. Voltage-gated sodium channels contribute to the b-wave of the rodent electroretinogram by mediating input to rod bipolar cell GABAc receptors. Experimental Eye Research, Vol. 116, p. 279.

    Martin, Brent T. List, Edward O. Kopchick, John J. Sauvé, Yves and Harvey, Steve 2011. Selective inner retinal dysfunction in growth hormone transgenic mice. Growth Hormone & IGF Research, Vol. 21, Issue. 4, p. 219.

    Qian, Haohua and Ripps, Harris 2011. Neurovascular Interaction and the Pathophysiology of Diabetic Retinopathy. Experimental Diabetes Research, Vol. 2011, p. 1.

    Vielma, Alex Delgado, Luz Elgueta, Claudio Osorio, Rodrigo Palacios, Adrián G. and Schmachtenberg, Oliver 2010. Nitric oxide amplifies the rat electroretinogram. Experimental Eye Research, Vol. 91, Issue. 5, p. 700.

    Delgado, Luz M. Vielma, Alex H. Kähne, Thilo Palacios, Adrián G. and Schmachtenberg, Oliver 2009. The GABAergic system in the retina of neonate and adultOctodon degus, studied by immunohistochemistry and electroretinography. The Journal of Comparative Neurology, Vol. 514, Issue. 5, p. 459.

    Traustason, Sindri Eysteinsson, Thor Agnarsson, Bjarni A. and Stefánsson, Einar 2009. GABA agonists fail to protect the retina from ischemia–reperfusion injury. Experimental Eye Research, Vol. 88, Issue. 3, p. 361.

    Kupenova, P. Popova, E. and Vitanova, L. 2008. GABAa and GABAc receptor mediated influences on the intensity-response functions of the b- and d-wave in the frog ERG. Vision Research, Vol. 48, Issue. 7, p. 882.

    Mojumder, Deb Kumar Sherry, David M. and Frishman, Laura J. 2008. Contribution of voltage-gated sodium channels to the b-wave of the mammalian flash electroretinogram. The Journal of Physiology, Vol. 586, Issue. 10, p. 2551.

    Moreno, María Cecilia de Zavalía, Nuria Sande, Pablo Jaliffa, Carolina O. Fernandez, Diego C. Keller Sarmiento, María Inés and Rosenstein, Ruth E. 2008. Effect of ocular hypertension on retinal GABAergic activity. Neurochemistry International, Vol. 52, Issue. 4-5, p. 675.

    Hetzler, Bruce E. and Ondracek, Janie M. 2007. Baclofen alters flash-evoked potentials in Long–Evans rats. Pharmacology Biochemistry and Behavior, Vol. 86, Issue. 4, p. 727.

    Chen, Jennifer C. Brown, Brian and Schmid, Katrina L. 2006. Evaluation of inner retinal function in myopia using oscillatory potentials of the multifocal electroretinogram. Vision Research, Vol. 46, Issue. 24, p. 4096.

    Lüke, Matthias Henry, Margit Lingohr, Thea Maghsoodian, Mehran Hescheler, Jürgen Weiergräber, Marco Sickel, Werner and Schneider, Toni 2005. A Ni2+-sensitive component of the ERG b-wave from the isolated bovine retina is related to E-type voltage-gated Ca2+ channels. Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 243, Issue. 9, p. 933.

    Pangratz-Fuehrer, Susanne Bubna-Littitz, Hermann Propst, Friedrich and Reitsamer, Herbert 2005. Mice deficient in microtubule-associated protein MAP1B show a distinct behavioral phenotype and altered retina function. Behavioural Brain Research, Vol. 164, Issue. 2, p. 188.


Modulation of the components of the rat dark-adapted electroretinogram by the three subtypes of GABA receptors

  • DOI:
  • Published online: 01 January 2004

The separate components of the dark-adapted electroretinogram (ERG) are believed to reflect the electric activity of neurones in both the inner and the outer layers of the retina, although their precise origin still remains unclear. The purpose of this study was to examine whether selective blockage or stimulation of the different subtypes of GABA receptors might help further elucidate the cellular origin of the components of the dark-adapted ERG. The rat retina is of interest since the localization and physiology of GABA receptors in that retina have been examined in great detail. GABA agonists and antagonists, known to affect the responses of neurons in the inner plexiform layer, were injected into the vitreous of one eye while ERG responses evoked by flashes of white light were recorded. GABA and the GABAa agonist isoguvacine completely removed the oscillatory potentials (OPs) and reduced the amplitude of the a- and b-waves. TPMPA, a GABAc antagonist, reduced the a- and b-waves but had no significant effect on the OPs. Baclofen, a GABAb agonist, reduced the amplitude of the a- and b-waves, without having any effects on the amplitude of the OPs. The GABAb antagonist CGP35348 increased the amplitudes of the a- and b-wave without having an effect on the amplitudes of the OPs. The GABAb receptor ligands had significant and opposite effect on the latency of the OPs. These results indicate that retinal neurons, presumably a subpopulation of amacrine cells, that have GABAb receptors are not the source of the OPs of the ERG, although they may modulate these wavelets in some manner, while contributing to the generation of the dark-adapted a- and b-waves. OPs are modified by stimulation of GABAa receptors, and the a- and b-waves by stimulation of all GABA receptor subtypes.

Corresponding author
Address correspondence and reprint requests to: Thor Eysteinsson, Department of Physiology, University of Iceland, Vatnsmyrarvegi 16, IS-101 Reykjavik, Iceland. E-mail:
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Visual Neuroscience
  • ISSN: 0952-5238
  • EISSN: 1469-8714
  • URL: /core/journals/visual-neuroscience
Please enter your name
Please enter a valid email address
Who would you like to send this to? *