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Neuroactive peptides as markers of retinal ganglion cell populations that differ in anatomical organization and function

Published online by Cambridge University Press:  02 June 2009

Rodrigo O. Kuljis  and
Harvey J. Karten
Rodrigo O. Kuljis
Affiliation:
Section of Neuroanatomy, Yale University School of Medicine, New Haven
Harvey J. Karten
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla
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Abstract

Recent immunocytochemical studies indicate the existence of several classes of peptide- (PRGC) and catecholamine-containing retinal ganglion cells in anurans, birds, and mammals. Different classes of PRGC project to discrete and seemingly unique layers in the retino-recipient portion of the anuran and avian optic tectum. Peptide-containing retinofugal projections to the frog tectum originate early in development, and are reestablished by some classes of PRGC during regeneration of the optic nerve. These findings indicate that chemically specific, parallel retinofugal pathways presumably subserve different functional aspects of vision in vertebrates. Exciting prospects for research include the correlation of physiologically with immunocytochemically defined classes of retinal ganglion cells, the analysis of the possible role of neuroactive peptides in retinofugal transmission, and the pharmacological manipulation of putative peptidergic retinofugal pathways to analyze their role in visual function.

Keywords

Retinal ganglion cellsNeuropeptidesOptic tectumOptic nerve

Information

Type
Research Articles
Information
Visual Neuroscience , Volume 1 , Issue 1 , January 1988 , pp. 73 - 81
Copyright
Copyright © Cambridge University Press 1988

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